Dr Vincent Croset
(email at email@example.com)
I obtained my PhD from the University of Lausanne (Switzerland), working on the evolution and function of a then novel family of chemosensory receptors, in the lab of Richard Benton. There, I traced the evolution of these receptors across the genomes of dozens of invertebrates, and found a function for one of them in tasting amino-acids. After graduating in 2013, I moved to the Centre for Neural Circuits and Behaviour at the University of Oxford to work with Scott Waddell on transcriptomic variability in the Drosophila brain. There, I generated the first atlas of single-cell transcriptomes from the fly brain, which I used to identify new genes that define cell types, and resolve transmitter co-expression and receptor assembly. I also used single-cell transcriptomics to address state-dependent gene expression changes induced by thirst.
In our brain, modulation of gene expression influences the activity of particular neurons and circuits to regulate essential functions such as memory, sleep, feeding or social interactions. In turn, neuronal activity and plasticity also influence the expression of specific genes, to regulate neurotransmission, and maintain homeostasis. We use the simple brain of the fruit fly Drosophila melanogaster as a model to understand the interplay between neuronal activity and transcription. Using single-cell transcriptomics, behaviour and neuronal imaging, we are able to identify novel genes and pathways that sustain key neuronal functions, with an unprecedented level of detail. Description of these general mechanisms could inform treatments against neurological conditions, such as addiction or neurodegenerative diseases.
Department of Biosciences
- Allen, A.M., Neville, M.C., Birtles, S., Croset, V., Treiber, C.D., Waddell, S. & Goodwin, S.F. (2020). A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord. eLife 9: e54074.
- Sánchez-Alcañiz, J.A., Silbering, A.F., Croset, V., Zappia, G., Sivasubramaniam, A.K., Abuin, L., Sahai, S.Y., Münch, D., Steck, K., Auer, T.O., Cruchet, S., Neagu-Maier, G.L., Sprecher, S.G., Ribeiro, C., Yapici, N. & Benton, R. (2018). An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing. Nature Communications 9(1): 4252.
- Croset, V., Treiber, C.D. & Waddell, S. (2018). Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics. eLife 7: e34550.
- Croset, V., Schleyer, M., Arguello, J.R., Gerber, B. & Benton, R. (2016). A molecular and neuronal basis for amino acid sensing in the Drosophila larva. Scientific Reports 6.
- Chen, C., Buhl, E., Xu, M., Croset, V., Rees, J.S., Lilley, K.S., Benton, R., Hodge, J.J.L. & Stanewsky, R. (2015). Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature. Nature 527(7579): 516-520.
- Rytz, R., Croset, V. & Benton, R. (2013). Ionotropic Receptors (IRs): Chemosensory ionotropic glutamate receptors in Drosophila and beyond. Insect Biochemistry and Molecular Biology 43(9): 888-897.
- Croset, V., Rytz, R., Cummins, S.F., Budd, A., Brawand, D., Kaessmann, H., Gibson, T.J. & Benton, R. (2010). Ancient protostome origin of chemosensory ionotropic glutamate receptors and the evolution of insect taste and olfaction. PLoS Genetics 6(8).