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Research

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Dr P Chazot, BSc (Hons) ARCS PhD

Associate Professor in the Department of Biosciences
Telephone: +44 (0) 191 33 41305
Room number: 163
Telephone: +44 (0) 191 33 41305

Contact Dr P Chazot (email at paul.chazot@durham.ac.uk)

Biography

My research group focuses on the identification, characterisation and validation of novel drug targets for the treatment of the major acute and chronic CNS pathologies. We also are developing novel all-in-one behavioural tests for both animals and humans.

Major Research Roles:

  • PRESIDENT, European Histamine Research Society (EHRS) (2012-2018)
  • FELLOW and AMBASSADOR, British Pharmacological Society (2012-present day)
  • VICE CHAIR and CO-APPLICANT, EU COST ACTION BM0806 (2009-2013)
  • CHAIR, International Union of Pharmacological Societies Subcommittee (2011-present day)
  • DURHAM LGR/COMMITTEE OFFICER (2008- ) British Neuroscience Association
  • PRESIDENT, Parkinson’s UK North Durham Branch (2010 – present day)
  • SCIENCE EDITOR & CO-FOUNDER, Trends in Anaesthesia and Critical Care (TACC) (2010-)
  • THEME EDITOR, Histamine Pharmacology 2009 and 2013 British Journal of Pharmacology
  • ASSISTANT EDITOR Inflammation Research (2004-present day)
  • EDITOR: European Journal of Medicinal Plants (2011- )
  • FOUNDER and DIRECTOR, WOLFSON RESEARCH INSTITUTE SPECIAL INTEREST GROUP – PAIN (2012-present day)

Major Publications since 2001

  1. Panula P, Chazot PL et al. (2015) International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev. 2015 Jul;67(3):601-65
  2. S Abuhamdah et al. Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora Palau. J Pharm Pharmacol. 2015 Apr 16. doi: 10.1111/jphp.12424. [Epub ahead of print]
  3. R Abuhamdah et al. Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress. 2015 (in press)
  4. Chen Y, Stegaev V, Kouri VP, Sillat T, Chazot PL, Stark H, Wen JG, Konttinen YT. (2015) Identification of histamine receptor subtypes in skeletal myogenesis. Mol Med Rep. 11(4):2624-30
  5. Chen Y et al Activation of histamine H3 receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes. Eur J Pharmacol. 2015 May 5;754:173-8.
  6. A Pini*, PL Chazot*, E Veglia, A Moggio, AC Rosa. H3 receptor renal expression in normal and diabetic rats. (2015) Inflammation Res. (submitted) * Joint first author May;64(5):271-3
  7. E Veglia, C Grange, A Pini, A Moggio, C Lanzi, G Camuss, PL Chazot5 and AC Rosa. Histamine receptor functionalexpression in the human renal tubules: a comparative pharmacological evaluation. (2015) Inflammation Res. Apr;64(3-4):261-70
  8. Duggett N and Chazot PL. Low-Intensity Light Therapy (1068 nm) Protects CAD Neuroblastoma Cells from β-Amyloid-Mediated Cell Death. Biology and Medicine (2015) 7 (1) in press
  9. S Abuhamdah, R Abuhamdah, M-J R. Howes, S Al-Olimat, A Ennaceur PL Chazot African J Pharm Pharmacol (2015) 8, 1235-12 Neuropharmacological evaluation of a selection of Jordanian herbal plants
  10. M Mahita, S Abuhamdah, A Ennaceur and PL Chazot Eur J Med Plants (2014) 4(7) Identification of a novel GABAA receptor ligand from Aloysia citrodora Palau
  11. Dib K, Perecko T, Jenei V, McFarlane C, Comer D, Brown V, Katebe M, Scheithauer T, Thurmond RL, Chazot PL, Ennis M. The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. J Leukoc Biol. 2014 May 5. [Epub ahead of print]
  12. Ballerini C, Aldinucci A, Luccarini I, Galante A, Manuelli C, Blandina P, Katebe M, Chazot PL, Masini E, Passani MB. Br J Pharmacol. 2013 170(1):67-77. Antagonism of histamine H4 receptor exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.
  13. Stegaev V, Nies AT, Porola P, Mieliauskaite D, Sánchez-Jiménez F, Urdiales JL, Sillat T, Schwelberger HG, Chazot PL, Katebe M, Mackiewicz Z, Konttinen YT, Nordström DC. Rheumatology (Oxford). 2013 May 24. [Epub ahead of print] Histamine transport and metabolism are deranged in salivary glands in Sjogren's syndrome.
  14. Grillo SL, Duggett NA, Ennaceur A, Chazot PL. J Photochem Photobiol B. 2013 Jun 5;123:13-22. Non-invasive infra-red therapy (1072nm) reduces β-amyloid protein levels in the brain of an Alzheimer's disease mouse model, TASTPM.
  15. Rosa AC, Grange C, Pini A, Katebe MA, Benetti E, Collino M, Miglio G, Bani D, Camussi G, Chazot PL, Fantozzi R. Inflamm Res. 2013 Apr;62(4):357-65. H4 receptor renal over expression in diabetic rats
  16. Abuhamdah RM, van Rensburg R, Lethbridge NL, Ennaceur A, Chazot PL. Frontiers in Systems Neuroscience, 2012;6:54. Effects of methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to a radial-arm maze.
  17. Wang M*, Chazot PL*, Ali S, Duckett SF, Obrenovitch TP. Br J Pharmacol. 2012 Jan;165(1):235-44. Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. (* joint first author)
  18. Vasily Stegaev, Tarvo Sillat, Pauliina Porola, Arno Hänninen, András Falus, Diana Mieliauskate, Edit Buzás, Ziga Rotar, Zygmunt Mackiewicz, Holger Stark, Paul L. Chazot, Yrjö T. Konttinen. (2012) Arthritic Rheum 64(8):2663-8. First identification of the histamine 4 receptors (H4R) in healthy salivary glands and in focal sialadenitis 
  19. Gutzmer R, Werfel T, Bäumer W, Kietzmann M, Chazot PL, Leurs R. Naunyn Schmiedebergs Arch Pharmacol. 2012 385(9):853-4. Well characterized antihistamine 4 receptor antibodies contribute to current knowledge of the expression and biology of the human and murine histamine 4 receptor. 
  20. Burns A, Perry E, Holmes C, Francis P, Morris J, Howes MJ, Chazot PL, Lees G, Ballard C. (2011) Dement Geriatr Cogn Disord. 2011;31(2):158-64. A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.
  21. Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. Neuropharmacology. 2011 Oct-Nov;61(5-6):981-91. MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation.
  22. Shan, L, Bossers, K, Luchetti, S, Balesar, R, Lethbridge, N, Chazot, PL, Bao, A-M and Swaab, D (2011) Neurobiology of Ageing Jul;33(7):1488.e1-13. Alterations of the histaminergic system in the substantia nigra and striatum of Parkinson’s Disease patients: a post-mortem study 
  23. Ennaceur A, Michalikova S, van Rensburg R, Chazot PL. Behav Brain Res. 2010 209(1):154-64. Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test.
  24. Lethbridge NL, Chazot PL. Inflamm Res. 2010 59 Suppl 2:S197-8. Immunological identification of the mouse H4 histamine receptor on spinal cord motor neurons using a novel anti-mouse H4R antibody.
  25. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2010) Behavioural Brain Res 207(2):402-17.Anxiety responses in Balb/c, c57 and CD-1 mice exposed to a novel open space test.
  26. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2010) Behavioural Brain Res 207(1):84-98. Distinguishing anxiolysis and hyperactivity in an open space behavioral test.
  27. V Feigin, M Hennerici, B Dubois, P Rothwell, S Evers, P-M Preux, F Bermejo Pareja, PM Lavados, K Nagata, G Logroscino, J Kesselring, D Bennett, S Barker-Collo, B Stegmayr, PL Chazot, S Li, M Brainin, W Wang (2009) Neuroepidemiology 33, 296-304 Bridging the Gap between Experimental and Non-Experimental Neuroepidemiology, and Ultimately – between Neuroepidemiological Research and Practice: Round Table Discussion at the First International Congress on Clinical Neurology and Epidemiology
  28. P Giannoni, M-P Passani, D Nosi, PL Chazot, FC Shenton, AD Medhurst, L Munari, P Blandina (2009) Eur. J. Neurosci. 29, 2363-2374. Heterogeneity of histaminergic neurons in the tuberomammilary nucleus of the rat
  29. Ennaceur A, Michalikova S, Chazot PL. (2009) Behavioural Brain Res. 197(2):417-34 Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space.
  30. NL Lethbridge, FC Shenton and PL Chazot (2009) Inflamm. Res 58, 43-44. Generation and characterisation of the first anti-human H3R445/453 isoform specific antibody probe.
  31. R van Rensburg, DR Errington, A Ennaceur, G Lees, TP Obrenovitch and PL Chazot (2008) J Neuroscience Methods 177(2):311-6.A new model for the study of high K+-induced preconditioning in cultured neurons: role of N-methyl-D-aspartate and a7-nicotinic acetylcholine receptors
  32. van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R. (2008) Biochem J. 414(1):121-31. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
  33. S Abuhamdah, L Huang, MSJ Elliot, C Ballard, C Holmes, A Burns, EK Perry, P Francis, G Lees and PL Chazot (2008) Journal of Pharmacy and Pharmacology 60(11):1515-22. Pharmacological Profile of an essential oil derived from Lavandula with anti-agitation properties: focus on Ligand-gated ion channels (LGICs) 
  34. W Bäumer, S Wendorff, R Gutzmer, T Werfel, D Dijkstra, PL Chazot, H Stark and M. Kietzmann (2008) Allergy 63(10):1387-94. Dendritic cell migration through skin is modulated via the histamine H4 receptor. Implications for an immunomodulatory role of histamine
  35. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2008b) Behavioural Brain Res. 188(1):136-153 Are benzodiazepines really anxiolytics? Evidence from multiple strains of mice with variable levels of innate anxiety in the 3D maze
  36. S Abuhamdah, L Huang, MSJ Elliot, C Ballard, C Holmes, A Burns, EK Perry, P Francis, G Lees and PL Chazot (2008) Journal of Pharmacy and Pharmacology 60(3):377-84. Pharmacological Profile of an essential oil derived from Melissa officinalis with anti-agitation properties: focus on Ligand-gated ion channels (LGICs)
  37. D Grandi, FC Shenton, PL Chazot and G Morini (2008) Inflammation Res (Suppl.) 57 Suppl 1:S57-8. Differential expression of histamine H3 and H4 receptors on endocrine cells in the rat gastrointestinal tract
  38. MSJ Elliot, S Abuhamdah, M.J.R. Howes, C Ballard, C Holmes, A Burns, G Lees, PL Chazot, P Francis and EK Perry (2008) International Journal of Essential Oil Therapeutics Pharmacological Profile of two essential oils derived from Melissa officinalis and Lavendula angustifolia with anti-agitation properties
  39. D Dijkstra, H Stark, PL Chazot, FC Shenton, R Leurs, T Werfel and R Gutzmer (2008) J Clin Invest Dermatology 128(7):1696-703. Human inflammatory dendritic epidermal cells (IDEC) express a functional histamine H4 receptor
  40. D Grandi, FC Shenton, PL Chazot and G Morini (2008) Histology and Histopathology 23(7):789-98. Immunolocalisation of histamine H3 receptors on endocrine cells in the rat gastrointestinal tract
  41. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2008a) Behavioural Brain Res. 187(2):312-26. Detailed Analysis of the Behavior and Memory Performance of Middle-aged male and female CD-1 mice in a 3D maze
  42. Michalikova S, Ennaceur A, van Rensburg R, Chazot PL. Neurobiol Learn Mem. 2008 May;89(4):480-8. Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: effects of low infrared light.
  43. PL Chazot, FC Shenton, W. Schunack, D. Grandi and G. Morini (2007) Inflammation Res. Suppl 1:S19-20. Influence of (R)-α-Methylhistamine on the histamine H3 receptor in the rat gastrointestinal tract
  44. D Dijkstra , R Leurs, PL Chazot, FC Shenton, H Stark, T Werfel and R Gutzmer (2007) Journal of Allergy and Clinical Immunology 120(2):300-307.  Histamine down-regulates monocyte CCL2 production via the histamine H4 receptor
  45. KE Cannon, PL Chazot, V Hann, FC Shenton, LB Hough and F Rice (2006) Pain 129(1-2):76-92. Spinal Histamine H3 receptor-mediated antinociception and localization on Sensory neurons
  46. PL Chazot*, R Van Rijn*, FC Shenton, RA Bakker and R Leurs (2006) Mol. Pharmacol. 70, 604-615 Homo and hetero-oligomerisation of the human histamine H4 receptor (*joint first author)
  47. A Ennaceur, S Michalikova, ST Wilson and PL Chazot (2006) Behavioural Brain Res. 171 26-49. Models of anxiety: rat responses to novelty in an open space and enclosed space 3 MOST DOWNLOADED ARTICLE FOR THIS JOURNAL 2006
  48. A Ennaceur, S Michalikova, R van Rensburg and PL Chazot (2006) Behavioural Brain Res 174, 9-38. Models of anxiety: responses of mice to novelty and open spaces in a 3D-maze
  49. RA Bakker, AF Lozada, A Van Marle, FC Shenton, RM Van Rijn, K Karlstedt, M Hoffmann, M Lintunen, Y Yamamoto, G Drutel, PL Chazot, P Panula and R Leurs (2006) Mol Pharmacol. 69, 1194-1206. Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant negatives
  50. FC Shenton and PL Chazot (2005) Inflammation Res. 55, 55, 40-41. Probing the importance of N-glycosylation for [3H] clobenpropit binding to human H3 receptors expressed in HEK 293 cells
  51. Abuhamdah, S, Fuerstner, A, Lees, G and Chazot, PL (2005) Biochem. Pharmacol. 70, 1382-1388. Pharmacological binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to mammalian GABAA receptor
  52. Bradford, A, Barlow, A and Chazot PL (2005) Photochemistry and Photobiology B: Biology 81, 9-14. Probing the effects of infrared light sources IR1072 and IR880 on human lymphocytes: evidence of cytoprotection by IR1072 through an NO-mediated pathway
  53. FC Shenton, V Hann and PL Chazot (2005) Inflammation Res. 54, 48-49 Evidence for native and cloned H3 histamine receptor higher oligomers
  54. V Hann, FC Shenton and PL Chazot (2004) Inflammation Res. 53, 67-68 GTP-insensitive agonist binding to native and recombinant H3 receptors
  55. N Rezai, C Duggan, D Cairns, G Lees and PL Chazot (2003) Biochem. Pharmacol. 65, 619-623 Positive modulation of [3H] TBOB binding to rat brain GABAA receptors by simple disaccharide sugars
  56. PL Chazot, OV Godukhin, A McDonald and TP Obrenovitch. (2002) J. Neurochem. 83 1235-1238. Spreading Depression-induced preconditioning in the mouse cortex: Differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors
  57. M Beck, K Brickley, HL Wilkinson, S Sharma, M Smith, PL Chazot, S Pollard and FA Stephenson (2002) J. Biol. Chem. 277, 30079-30090 Identification, molecular cloning and characterisation of a novel GABAA receptor associated protein, GRIF-1
  58. PL Chazot, S Lawrence and CL Thompson. (2002) Neuropharmacology 42, 319-324. Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists
  59. CL Thompson, DL Drewery, HD Atkins, FA Stephenson and PL Chazot. (2002) Molecular Brain Res. 102, 55-61. Immunohistochemical localisation of NMDA receptor subunits in the mammalian hippocampal formation: Evidence for a unique role for the NR2D subunit.
  60. T Obrenovitch, O Godukhin and PL Chazot (2002) Neurosci. Letts. 320, 161-163. Repetitive Spreading Depression induces Nestin protein expression in the cortex of rats and mice. Is up-regulation initiated by NMDA receptors?
  61. PL Chazot, V Hann, C Wilson, G Lees and CL Thompson. (2001) NeuroReport 12 (2) 259-262. Immunological identification of the mammalian H3 histamine receptor in the adult mouse brain. 

Current Academic Role:

  • Module Leader Biology of Disease
  • Library Tutor
  • Industrial Placement Tutor
  • Wolfson SIG Leader Pain
  • Hatfield College Mentor

Previous Academic Roles:

  • Module Leader Pharmacology
  • Module Leader Neuroscience
  • Admissions Tutor Biomedical Sciences
  • Pharmacology co-ordinator Phase 1 Medicine
  • Hatfield College Committee member
  • External Examiner - Biomedical Sciences, Pharmacology & Intercalated Medical Degrees (University of Bradford)

Research Groups

Department of Biosciences

Wolfson Research Institute for Health and Wellbeing

Research Interests

  • Dr Chazot’s group is interested in identifying, studying and validating novel drug targets for treating acute brain damage and a range of common chronic neuro- and immuno-pathologies.
  • His favourite molecules to study are histamine (http://www.ehrs.org.uk/ and http://www.histamineresearch.com) and glutamate.
  • Technologies employed include immunobiochemistry, molecular biology, ligand autoradiography, radioligand binding, heterologous expression, primary neuronal cultures, adenoviral transfection, in vitro electrophysiology, in vivo behavioural testing

Selected Publications

Journal Article

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Media Contacts

Available for media contact about:

  • Biological and Biomedical Sciences: How the brain functions normally & what goes wrong in major brain diseases and disorders & how these are currently being treated and will be treated in the future

Supervises