Publication detailsChisholm, David, Lamb, Rebecca, Pallett, Tommy, Affleck, Valerie, Holden, Claire, Marrison, Joanne, O'Toole, Peter, Ashton, Peter, Newling, Katherine, Steffen, Andreas, Nelson, Amanda, Mahler, Christoph, Valentine, Roy, Blacker, Thomas, Bain, Angus John, Girkin, John M, Marder, Todd B, Whiting, Andrew & Ambler, Carrie A (2019). Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene. Chemical Science 10(17): 4673-4683.
- Publication type: Journal Article
- ISSN/ISBN: 2041-6520 (print), 2041-6539 (electronic)
- DOI: 10.1039/C9SC00199A
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Photoactivation of photosensitisers can be utilised to elicit the production of ROS, for potential therapeutic applications, including the destruction of diseased tissues and tumours. A novel class of photosensitiser, exemplified by DC324, has been designed possessing a modular, low molecular weight ‘drug-like’ structure which is bioavailable and can be photoactivated by UV-A/405 nm or corresponding two-photon absorption of near-IR (800 nm) light, resulting in powerful cytotoxic activity, ostensibly through the production of ROS in a cellular environment. A variety of in vitro cellular assays confirmed ROS formation and in vivo cytotoxic activity was exemplified via irradiation and subsequent targeted destruction of specific areas of a zebrafish embryo.