Publication details for Professor Martin CannWilliamson, D., Cann, M.J. & Hodgson, D.R.W. (2007). Synthesis of 5'-Amino-5'-deoxyguanosine-5'-N-phosphoramidate and its Enzymatic Incorporation at the 5'-Termini of RNA Molecules. Chemical Communications 2007(47): 5096-5098.
- Publication type: Journal Article
- ISSN/ISBN: 1359-7345, 1364-548X
- DOI: 10.1039/b712066d
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
5-Amino-5-deoxyguanosine-5-N-phosphoramidate (GNHP) was synthesized in four steps from guanosine and was found to initiate T7 RNAP-promoted transcriptions to afford 5-H2N-RNA that can be conjugated to activated esters.