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Durham University

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Publication details for Dr Junli Liu

Moore, S., Zhang, X., Liu, J. & Lindsey, K. (2015). Modelling plant hormone gradients. eLS 1-10.

Author(s) from Durham


Cellular patterning in the Arabidopsis root is coordinated via a localised auxin concentration maximum in the root tip, requiring the regulated expression of specific genes. The activities of plant hormones such as auxin, ethylene and cytokinin depend on cellular context and exhibit either synergistic or antagonistic interactions. Due to the complexity and nonlinearity of spatiotemporal interactions between both hormones and gene expression in root development, modelling plant hormone gradients requires a systems approach in which experimental data and modelling analysis are closely combined. Modelling therefore allows a predictive interrogation of highly complex and nonintuitive interactions between components in the system. Important factors to be considered when modelling hormone gradients include the construction of a hormonal crosstalk network, the formulation of kinetic equations and the construction of an in silico root map. A modelling approach enables the analysis of relationships between multiple hormone gradients, predictions on how hormone gradients emerge under the action of hormonal crosstalk, and the prediction and elucidation of experimental results from mutant roots.