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Durham University

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Publication details for Prof. Patrick G. Steel

Sadler, S. A., Hones, A. C., Roberts, B., Blakemore, D.C., Marder, T. B. & Steel, P.G. (2015). Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation. The Journal of Organic Chemistry 80(10): 5308-5314.

Author(s) from Durham


In the absence of a steric directing group, iridium-catalyzed C–H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolerance of the iridium-catalyzed C–H borylation reaction enables simple and efficient multidirectional syntheses of substituted indazoles to be realized.