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Durham University

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Publication details for Prof. Patrick G. Steel

Scott, P.J.H. & Steel, P.G. (2006). Diversity linker units for solid-phase organic synthesis. European Journal of Organic Chemistry 2006(10): 2251-2268.

Author(s) from Durham


In recent years an ever-increasing number of traditional solution-phase reactions have been adapted for solid-phase organic synthesis (SPOS) because of the ease of application of solid-phase techniques to combinatorial chemistry and high-throughput screening. To accommodate the growing number of reactions being attempted on solid supports, new linker units continue to be reported in the literature. Linker units are typically grouped according to the functionality left at the “cleavage site” in the target molecule, and are normally classified as traditional (polar functionality remains following cleavage) or traceless (hydrogen residue left after cleavage) linkers. As the field continues to expand, however, more advanced linker units have been reported, which utilise the cleavage step in SPOS to incorporate additional diversity into target libraries. These linker units have been termed “diversity” or “multifunctional” linker units, and in this microreview we introduce this aspect of the field, giving representative examples indicating key stages of development including the linker units recently designed in our laboratory.