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Durham University

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Publication details for Prof. David Parker

Parker, David, Shuvaev, Sergey & Fox, Mark A. (2018). Monitoring the ADP/ATP ratio via induced circularly‐polarised europium luminescence. Angewandte Chemie International Edition 57(25): 7488-7492.

Author(s) from Durham


A series of three europium complexes is reported bearing picolyl amine moieties with different substituents, that possess differing binding affinities towards Zn2+ and three nucleotides ‐ AMP, ADP and ATP. A large increase of the total emission intensity was observed upon binding Zn2+, followed by further signal amplification upon addition of nucleotides. The resulting adducts possess strong induced circularly polarised emission, with ADP and ATP signals being of opposite sign. Model DFT geometries of the adducts suggest the Δ diastereoisomer is preferred for ATP and the Λ isomer for ADP/AMP. Such a change in sign allows the ADP:/ATP (or AMP/ATP) ratio to be assessed by monitoring changes in the emission dissymmetry factor, gem.