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Durham University

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Publication details for Dr David R.W. Hodgson

Korhonen, H. J., Bolt, H. L. & Hodgson, D. R. W. (2015). A procedure for the preparation and isolation of nucleoside-5’-diphosphates. Beilstein Journal of Organic Chemistry 11: 469-472.

Author(s) from Durham


Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5’-diphosphates from crude reaction mixtures.