Publication details for Dr David R.W. HodgsonKorhonen, H. J., Bolt, H. L. & Hodgson, D. R. W. (2015). A procedure for the preparation and isolation of nucleoside-5’-diphosphates. Beilstein Journal of Organic Chemistry 11: 469-472.
- Publication type: Journal Article
- ISSN/ISBN: 1860-5397
- DOI: 10.3762/bjoc.11.52
- Keywords: NDP synthesis, Nucleic acids, Nucleoside-5’-diphosphate, Phosphorylation.
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5’-diphosphates from crude reaction mixtures.