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Durham University

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Publication details for Prof. Ivana Evans

J. M. Rubin-Preminger, J. Bernstein, R. K. Harris, I. R. Evans & P. Y. Ghi (2004). Variable temperature studies of a polymorphic system comprising two pairs of enantiotropically related forms: S,S -ethambutol dihydrochloride. Crystal Growth and Design 4(3): 431-439.

Author(s) from Durham


Of the four known polymorphs of [S,S] -ethambutol dihydrochloride, two transform in an enantiotropic single-crystal-to-single-crystaI phase transformation from Form II to Form I on heating. The crystal structures of these two forms have been solved and compared. Because the other two forms are metastable and are only obtained from the melt, single-crystal data could not be obtained on them. However, all four forms have been characterized, and their relative thermodynamic relationships have been investigated by variable-temperature solid-state C-13 NMR, variable-temperature powder X-ray diffraction studies, differential scanning calorimetry, and optical microscopy.