Publication details for Dr Martin Schröder

M. Schröder (2008). Engineering eukaryotic protein factories. Biotechnology Letters 30(2): 187-196.

• Publication type: Journal Article
• ISSN/ISBN: 0141-5492, 1573-6776
• DOI: 10.1007/s10529-007-9524-1
• Keywords: Unfolded protein response, Endoplasmic reticulum, Molecular chaperone, Recombinant protein production, Heterologous protein production, Protein folding.
• Further publication details on publisher web site
• Durham Research Online (DRO) - may include full text

Author(s) from Durham

• Dr Martin Schröder

Abstract

The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.