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Durham University

Research & business

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Publication details for Dr Martin Schröder

M. Schröder (2008). Engineering eukaryotic protein factories. Biotechnology Letters 30(2): 187-196.

Author(s) from Durham


The biopharmaceuticals market is currently outperforming the pharmaceuticals market and is now valued at US$ 48 billion with an average annual growth of 19%. Behind this success is a 100-fold increase in productivities of eukaryotic expression systems. However, the productivity per cell has remained unchanged for more than 10 years. The engineering of the ER-resident protein folding machinery is discussed together with an overview of signal transduction pathways activated by heterologous protein overexpression to increase cell specific productivities.