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Durham University

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Publication details for Dr Martin Schröder

N. Strudwick & M. Schröder (2007). The unfolded protein response. In Cell Engineering Vol 5: Systems Biology. M. Al-Rubeai & M. Fussenegger Dordrecht: Springer Netherlands. 5: 69-157.

Author(s) from Durham


Protein folding is the rate-limiting step for secretion of recombinant proteins in nearly all expression systems. Overexpression of recombinant proteins easily exhausts the cellular protein folding machinery in the endoplasmic reticulum (ER). In this ER stress situation a signal transduction network, called the unfolded protein response (UPR), is activated. The UPR coordinates adaptive responses to this stress situation and, presumably in response to prolonged ER stress, induces apoptosis. A molecular understanding of the UPR will enable the engineering of expression systems with the aim to increase cellular productivities and to improve the cost effectiveness of these expression systems. In this paper we review our current molecular understanding of the UPR and its implications for the engineering of recombinant protein expression systems.