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Publication details for Professor Felicity Callard

Patel, R., Oduola, S., Callard, F., Wykes, T., Broadbent, M., Stewart, R., Craig, T. & McGuire, P. (2017). What proportion of patients with psychosis are willing to take part in research? A mental health electronic case register analysis. BMJ Open 7(3): e013113.

Author(s) from Durham


Objective: The proportion of people with mental health disorders who participate in clinical research
studies is much smaller than for those with physical health disorders. It is sometimes assumed that
this reflects an unwillingness to volunteer for mental health research studies. We examined this
issue in a large sample of patients with psychosis.
Design: Cross‐sectional study
Setting: Anonymised electronic mental health record data from the South London and Maudsley
NHS Foundation Trust (SLaM).
Participants: 5,787 adults diagnosed with a psychotic disorder.
Exposure: Whether approached prior to 1st September 2014 for consent to be approached about
research participation.
Main Outcome Measures: Number of days spent in a psychiatric hospital, whether admitted to
hospital compulsorily, and total score on the Health of the Nation Outcome Scale (HoNOS) between
1st September 2014 and 28th February 2015 with patient factors (age, gender, ethnicity, marital
status and diagnosis) and treating clinical service as covariates.
Results: 1,187 patients (20.5% of the total sample) had been approached about research
participation. Of those who were approached, 773 (65.1%) agreed to be contacted in future by
researchers. Patients who had been approached had 2.3 fewer inpatient days (95% CI ‐4.4, ‐0.3,
p=0.03), were less likely to have had a compulsory admission (odds ratio 0.65, 95% CI 0.50‐0.84,
p=0.001), and had a better HoNOS score (B coefficient ‐0.9, 95% CI ‐1.5, ‐0.4, p=0.001) than those
who had not. Among patients who were approached, there was no significant difference in clinical
outcomes between those agreed to research contact and those who did not.
Conclusions: About two‐thirds of patients with psychotic disorders were willing to be contacted
about participation in research. The patients who were approached had better clinical outcomes
than those who were not, suggesting that clinicians were more likely to approach patients who were
less unwell.