Publication details for Dr Martin GoldbergGoldberg, Martin W. (2017). Nuclear pore complex tethers to the cytoskeleton. Seminars in Cell & Developmental Biology 68: 52-58.
- Publication type: Journal Article
- ISSN/ISBN: 1084-9521 (print)
- DOI: 10.1016/j.semcdb.2017.06.017
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
The nuclear envelope is tethered to the cytoskeleton. The best known attachments of all elements of the cytoskeleton are via the so-called LINC complex. However, the nuclear pore complexes, which mediate the transport of soluble and membrane bound molecules, are also linked to the microtubule network, primarily via motor proteins (dynein and kinesins) which are linked, most importantly, to the cytoplasmic filament protein of the nuclear pore complex, Nup358, by the adaptor BicD2. The evidence for such linkages and possible roles in nuclear migration, cell cycle control, nuclear transport and cell architecture are discussed.