Cookies

We use cookies to ensure that we give you the best experience on our website. You can change your cookie settings at any time. Otherwise, we'll assume you're OK to continue.

Durham University

Psychology

Profile

Publication details for Dr Colin Lever

Lever, C , Burton, S Jeewajee, A Wills, TJ Cacucci, F Burgess N & O'Keefe J (2010). Environmental novelty elicits a later theta phase of firing in CA1 but not subiculum. Hippocampus 20(2): 229-234.

Author(s) from Durham

Abstract

The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1.

Contact Us

Ask us online