Peter Wyper, who recently joined the Department of Mathematical Sciences at Durham with a Royal Astronomical Society Fellowship, has just published an exciting model of solar eruptions in Nature with two colleagues from the NASA Goddard Space Flight Center.
40th Research Students’ Conference in Probability and Statistics held in Durham
The RSC is a large annual conference that is organised by PhD students for PhD students in any field relating to probability or statistics. Being a student conference, the RSC provides delegates with a friendly and relaxed environment to discuss research and exchange ideas. This year, our Durham PG students in Probability and Statistics organised the event, which turned out to be a great success.
Statistics Seminars: Issues in ROC surface analysis with an application to externally validated cognition in Parkinson disease screening
Presented by Christos Nakas, University of Thessaly
19 July 2011 14:15 in TBC
The diagnostic accuracy of the Montreal Cognitive Assessment (MoCA) has been established recently for screening externally validated cognition in Parkinson's disease (PD) (Dalrymple-Alford et al, 2010). Patients were classified as having either normal cognition (PD-N), mild cognitive impairment (PD-MCI), or dementia (PD-D). ROC curve methodology has been used to assess discrimination between two adjacent classes and the Youden index has been employed for cut-off point selection. ROC surface methodology has also been used for the assessment of the simultaneous discrimination of the three classes. Recently, Nakas et al (2010) proposed a generalization of the Youden index for the assessment of accuracy and cut-off point selection in simultaneous discrimination of three classes. In this work, we examine properties of the generalized Youden index and compare two- vs. three-class classification accuracy approaches when screening for cognition status in PD.
Dalrymple-Alford, J.C., Macaskill, M.R., Nakas, C.T., et al. (2010). The MoCA: Well suited screen for cognitive impairment in Parkinson Disease. Neurology, 75, 1717-1725.
Nakas, C.T., Alonzo, T.A. And Yiannoutsos, C.T. (2010). Accuracy and cut-off point selection in three-class classification problems using a generalization of the Youden index. Statistics in Medicine, 29, 2946-2955.