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Institute of Advanced Study

Prof Carlos Geraldes

COFUND Senior Research Fellow at Trevelyan College (April - June 2017)

With over 40 years of experience in the development and use of paramagnetic NMRP and having been Director of the Laboratory of Bioinorganic Chemistry and Biomedical NMR of the Centre of Neurosciences of the University of Coimbra, Geraldes has a strong international reputation.

Non-classical paramagnetic susceptibility and anisotropy

An active EPSRC project (2016-2018) is examining the study of lanthanide coordination complexes that serve as magnetic resonance imaging probes, recently termed PARASHIFT agents. The detailed characterisation of their chemical shift and relaxation behaviour requires a combination of variable field and temperature experiments to be undertaken by the Senior Fellow, in tandem with quantum chemical calculations being undertaken by collaborators (Dr I Kuprov) at Southampton. Further information on the magnetic anisotropy of these systems is gained by the parallel low T EPR and magnetic susceptibility measurements being carried out at Manchester, by Prof EJ McInnes and Dr N Chilton. The medium term aim is to devise new theories of shift and relaxation in Magnetic resoanance that allow experimentalists to design better probes for MR imaging in vivo. In this respect, the Durham group has a current joint grant with the Newcastle Magnetic Resonance Centre, where Prof AM Blamire is head of Medical Physics. The new range of PARASHIFT probes are being examined there for a variety of applications, including tumour imaging and pH and temperature mapping.