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Email and Telephone Directory

Staff Profile

Prof PJ Hussey

Professor in the Department of Biosciences
Telephone: +44 (0) 191 33 41335
Fax: +44 191 334 1201
Pro-Vice-Chancellor (Science) in the Faculty of Science
Telephone: +44 (0) 191 33 41017

Contact Prof PJ Hussey (email at p.j.hussey@durham.ac.uk)

Biography

Patrick J. Hussey is the Professor of Plant Molecular Cell Biology at the University of Durham. He received his PhD in Biology from the University of Kent at Canterbury in association with the John Innes Centre in Norwich. After postdoctoral work at the University of Minnesota and the John Innes Centre, he took up a lectureship in Royal Holloway University of London where he was awarded a Personal Chair in 1999. He moved to the University of Durham in 2000. His main interest is in the structure, function and regulation of the plant cytoskeleton and its potential role in biotechnology.

Research Groups

Department of Biosciences

  • Durham Centre for Bioimaging Technology
  • Molecular Plant Sciences

Research Interests

  • Actin associated proteins
  • Microtubule associated proteins
  • Novel design of herbicides and herbicide resistance
  • Plant cytoskeleton
  • Signalling to the cytoskeleton

Publications

Journal Article

  • Garagounis, Constantine, Kostaki, Kalliopi-Ioanna, Hawkins, Tim J., Cummins, Ian, Fricker, Mark D., Hussey, Patrick J., Hetherington, Alistair M. & Sweetlove, Lee J. (2017). Microcompartmentation of cytosolic aldolase by interaction with the actin cytoskeleton in Arabidopsis. Journal Of Experimental Botany 68(5): 885-898.
  • Wang, P., Hawes, C. & Hussey, P.J. (2017). Plant Endoplasmic Reticulum-Plasma Membrane Contact Sites. Trends in Plant Science 22(4): 289-297.
  • Wang, P., Richardson, C., Hawes, C. & Hussey, P.J. (2016). Arabidopsis NAP1 regulates the formation of autophagosomes. Current Biology 26(15): 2060-2069.
  • Siao, W., Wang, P., Voigt, B., Hussey, P.J. & Baluska, F. (2016). Arabidopsis SYT1 maintains stability of cortical endoplasmic reticulum networks and VAP27-1-enriched endoplasmic reticulum–plasma membrane contact sites. Journal of Experimental Botany 67(21): 6161-6171.
  • Craddock, Christian P., Adams, Nicolette, Kroon, Johan T.M., Bryant, Fiona M., Hussey, Patrick J., Kurup, Smita & Eastmond, Peter J. (2016). Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity. The Plant Journal
  • Moschou, P.N., Savenkov, E.I., Minina, E.A., Fukada, K., Reza, S.H., Gutierrez-Beltran, E., Sanchez-Vera, V., Suarez, M.F., Hussey, P.J., Smertenko, A.P. & Bozhkov, P.V. (2016). EXTRA SPINDLE POLES (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently of its role in anaphase progression. New Phytologist 212(1): 232-243.
  • Wang, Pengwei, Richardson, Christine, Hawkins, Timothy J., Sparkes, Imogen, Hawes, Chris & Hussey, Patrick J. (2016). Plant VAP27 proteins: domain characterization, intracellular localization and role in plant development. New Phytologist 210(4): 1311-1326.
  • Wang, Pengwei & Hussey, Patrick J. (2015). Interactions between plant endomembrane systems and the actin cytoskeleton. Frontiers in Plant Science 6: 422.
  • Liu, J. & Hussey, P.J. (2014). Dissecting the regulation of pollen tube growth by modeling the interplay of hydrodynamics, cell wall and ion dynamics. Frontiers in Plant Science 5: 392.
  • Liu, Junli, Lindsey, Keith & Hussey, Patrick J. (2014). Elucidating the regulation of complex signalling systems in plant cells. Biochemical Society Transactions 42(1): 219-223.
  • Hawkins, T.J., Deeks, M.J., Wang, P. & Hussey, P.J. (2014). The evolution of the actin binding NET superfamily. Frontiers in Plant Science 5: 254.
  • Galva, C., Kirik, V Lindeboom, J.J., Kaloriti, D. Rancour, D.M., Hussey, P.J., Bednarek, S.Y., Ehrhardt, D.W. & Sedbrook, J.C. (2014). The Microtubule Plus-End Tracking Proteins SPR1 and EB1b Interact to Maintain Polar Cell Elongation and Directional Organ Growth in Arabidopsis. The Plant Cell 26(11): 4409-4425.
  • Wang, Pengwei, Hawkins, Timothy J., Richardson, Christine, Cummins, Ian, Deeks, Michael J., Sparkes, Imogen, Hawes, Chris & Hussey, Patrick J. (2014). The Plant Cytoskeleton, NET3C, and VAP27 Mediate the Link between the Plasma Membrane and Endoplasmic Reticulum. Current Biology 24(12): 1397-1405.
  • Moschou, PN, Smertenko, AP, Minina, EA, Fukada, K, Savenkov, EI, Robert, S, Hussey, PJ & Bozhkov, PV (2013). The caspase-related protease separase (extra spindle poles) regulates cell polarity and cytokinesis in Arabidopsis. The Plant Cell 25(6): 2171-2186.
  • Fenyk, S, de San Eustaquio Campillo, A, Pohl, E, Hussey, PJ & Cann, MJ (2012). A Nucleotide Phosphatase Activity in the Nucleotide Binding Domain of an Orphan Resistance Protein from Rice. The Journal of Biological Chemistry 287(6): 4023-4032.
  • Deeks, Michael J., Calcutt, Joanna R., Ingle, Elizabeth K.S., Hawkins, Timothy J., Chapman, Sean, Richardson, A.Christine, Mentlak, David A., Dixon, Martin R., Cartwright, Frances, Smertenko, Andrei P., Oparka, Karl & Hussey, Patrick J. (2012). A Superfamily of Actin-Binding Proteins at the Actin-Membrane Nexus of Higher Plants. Current Biology 22(17): 1595-1600.
  • Tóth, R., Gerding-Reimers, C., Deeks, M.J., Menninger, S., Gallegos, R.M., Tonaco, I.A., Hübel, K., Hussey, P.J., Waldmann, H. & Coupland, G. (2012). Prieurianin/endosidin 1 is an actin-stabilizing small molecule identified from a chemical genetic screen for circadian clock effectors in Arabidopsis thaliana. The Plant Journal 71(2): 338-352.
  • Jiang, K, Sorefan, K, Deeks, MJ, Bevan, MW, Hussey, PJ & Hetherington, AM (2012). The ARP2/3 complex mediates guard cell actin reorganization and stomatal movement in Arabidopsis. The Plant Cell 24(5): 2031-2040.
  • Smertenko, Andrei P., Piette, Bernard & Hussey, Patrick J. (2011). The Origin of Phragmoplast Asymmetry. Current Biology 21(22): 1924-1930.
  • Liu, J.L., Piette, B.M.A.G., Deeks, M.J., Franklin-Tong, V.E. & Hussey, P.J. (2010). A Compartmental Model Analysis of Integrative and Self-Regulatory Ion Dynamics in Pollen Tube Growth. PLoS One 5(10): e13157.
  • Landrum, M, Smertenko, A, Edwards, R, Hussey, PJ & Steel, PG (2010). BODIPY probes to study peroxisome dynamics in vivo. Plant Journal 62(3): 529-538.
  • Liu, Junli, Grieson, Claire S., Webb, Alex A. R. & Hussey, Patrick J. (2010). Modelling dynamic plant cells. CURRENT OPINION IN PLANT BIOLOGY 13(6): 744-749.
  • Smertenko, Andrei P., Deeks, Michael J. & Hussey, Patrick J. (2010). Strategies of actin reorganisation in plant cells. Journal of Cell Science 123(17): 3019-3029.
  • Deeks, MJ, Fendrych, M, Smertenko, A, Bell, KS, Oparka, K, Cvrckova, F, Zarsky, V & Hussey, PJ (2010). The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain. Journal Of Cell Science 123(8): 1209-1215.
  • Piette, B.M.A.G., Liu, J., Peeters, K., Smertenko, A., Hawkins, T., Deeks, M., Quinlan, R., Zakrzewski, W.J. & Hussey, P.J. (2009). A Thermodynamic Model of Microtubule Assembly and Disassembly. PLoS ONE 4(8): e6378.
  • Buxton, GA, Clarke, N & Hussey, PJ (2009). Actin dynamics and the elasticity of cytoskeletal networks. Express Polymer Letters 3(9): 579-587.
  • Clement, M, Ketelaar, T, Rodiuc, N, Banora, MY, Smertenko, A, Engler, G, Abad, P, Hussey, PJ & Engler, JD (2009). Actin-Depolymerizing Factor2-Mediated Actin Dynamics Are Essential for Root-Knot Nematode Infection of Arabidopsis. Plant Cell 21(9): 2963-2979.
  • Camacho, L, Smertenko, AP, Perez-Gomez, J, Hussey, PJ & Moore, I (2009). Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase. Journal Of Cell Science 122(23): 4383-4392.
  • Dixon, D. P., Hawkins, T., Hussey, P. J. & Edwards, R. (2009). Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily. Journal of Experimental Botany 60(4): 1207-1218.
  • Sundstrom, JF, Vaculova, A, Smertenko, AP, Savenkov, EI, Golovko, A, Minina, E, Tiwari, BS, Rodriguez-Nieto, S, Zamyatnin, AA, Valineva, T, Saarikettu, J, Frilander, MJ, Suarez, MF, Zavialov, A, Stahl, U, Hussey, PJ, Silvennoinen, O, Sundberg, E, Zhivotovsky, B & Bozhkov, PV (2009). Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. Nature Cell Biology 11(11): 1347-U198.
  • Smertenko, AP, Kaloriti, D, Chang, HY, Fiserova, J, Opatrny, Z & Hussey, PJ (2008). The C-Terminal Variable Region Specifies the Dynamic Properties of Arabidopsis Microtubule-Associated Protein MAP65 Isotypes. The Plant Cell 20(12): 3346-3358.
  • Guermonprez, H, Smertenko, A, Crosnier, MT, Durandet, M, Vrielynck, N, Guerche, P, Hussey, PJ, Satiat-Jeunemaitre, B & Bonhomme, S (2008). The POK/AtVPS52 protein localizes to several distinct post-Golgi compartments in sporophytic and gametophytic cells. Journal Of Experimental Botany 59(11): 3087-3098.
  • Ketelaar, T, Allwood, EG & Hussey, PJ (2007). Actin organization and root hair development are disrupted by ethanol-induced overexpression of Arabidopsis actin interacting protein 1 (AIP1). New Phytologist 174(1): 57-62.
  • Deeks, MJ, Rodrigues, C, Dimmock, S, Ketelaar, T, Maciver, SK, Malho, R & Hussey, PJ (2007). Arabidopsis CAP1 - a key regulator of actin organisation and development. Journal Of Cell Science 120(15): 2609-2618.
  • Tahara, H, Yokota, E, Igarashi, H, Orii, H, Yao, M, Sonobe, S, Hashimoto, T, Hussey, PJ & Shimmen, T (2007). Clathrin is involved in organization of mitotic spindle and phragmoplast as well as in endocytosis in tobacco cell cultures. Protoplasma 230(1-2): 1-11.
  • Uhrig, JF, Mutondo, M, Zimmermann, I, Deeks, MJ, Machesky, LM, Thomas, P, Uhrig, S, Rambke, C, Hussey, PJ & Hulskamp, M (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development 134(5): 967-977.
  • Hussey, PJ, Ketelaar, T & Deeks, MJ (2006). Control of the actin cytoskeleton in plant cell growth. Annual Review Of Plant Biology 57: 109-125.
  • Smertenko, AP, Chang, HY, Sonobe, S, Fenyk, SI, Weingartner, M, Bogre, L & Hussey, PJ (2006). Control of the AtMAP65-1 interaction with microtubules through the cellcycle. Journal Of Cell Science 119(15): 3227-3237.
  • Lovy-Wheeler, A, Kunkel, JG, Allwood, EG, Hussey, PJ & Hepler, PK (2006). Oscillatory increases in alkalinity anticipate growth and may regulateactin dynamics in pollen tubes of lily. Plant Cell 18(9): 2182-2193.
  • Chilley, P.M., Casson, S.A. , Tarkowski, P., Wang, K.L.-C., Hawkins, N., Hussey, P.J. , Beale, M., Ecker, J.R. Sandberg, G.K. & Lindsey, K. (2006). The POLARIS peptide of Arabidopsis regulates auxin transport and root growth via effects on ethylene signaling. Plant Cell 18(11): 3058-3072.
  • S.A. Oh, A. Johnson, A. Smertenko, D. Rahman, S.K. Park, P.J. Hussey & D. Twell (2005). A divergent cellular role for the FUSED kinase family in the plant-specific cytokinetic phragmoplast. Current Biology 15(23): 2107-2111.
  • H.Q. Zheng, L. Camacho, E. Wee, B.A. Henri, J. Legen, C.J. Leaver, R. Malho, P.J. Hussey & I. Moore (2005). A Rab-E GTPase mutant acts downstream of the Rab-D subclass in biosynthetic membrane traffic to the plasma membrane in tobacco leaf epidermis. Plant Cell 17(7): 2020-2036.
  • M.J. Deeks, F. Cvrckova, L.M. Machesky, V. Mikitova, T. Ketelaar, V. Zarsky, B. Davies & P.J. Hussey (2005). Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. New Phytologist 168(3): 529-540.
  • M.J. Deeks & P.J. Hussey (2005). Arp2/3 and scar: Plants move to the fore. Nature Reviews Molecular Cell Biology 6(12): 954-964.
  • H.Y. Chang, A.P. Smertenko, H. Igarashi, D.P. Dixon & P.J. Hussey (2005). Dynamic interaction of NtMAP65-1a with microtubules in vivo. Journal of Cell Science 118(14): 3195-3201.
  • T. Ketelaar, C. Voss, S.A. Dimmock, M. Thumm & P.J. Hussey (2004). Arabidopsis homologues of the autophagy protein Atg8 are a novel family of microtubule binding proteins. FEBS Letters 567(2-3): 302-306.
  • M.J. Deeks, D. Kaloriti, B. Davies, R. Malho & P.J. Hussey (2004). Arabidopsis NAP1 is essential for Arp2/3-dependent trichome morphogenesis. Current Biology 14(15): 1410-1414.
  • T. Ketelaar, R.G. Anthony & P.J. Hussey (2004). Green fluorescent protein-mTalin causes defects in actin organization and cell expansion in arabidopsis and inhibits actin depolymerizing factor's actin depolymerizing activity in vitro. Plant Physiology 136(4): 3990-3998.
  • T. Ketelaar, E.G. Allwood, R. Anthony, B. Voigt, D. Menzel & P.J. Hussey (2004). The actin-interacting protein AIP1 is essential for actin organization and plant development. Current Biology 14(2): 145-149.
  • A.P. Smertenko, H.Y. Chang, V. Wagner, D. Kaloriti, S. Fenyk, S. Sonobe, C. Lloyd, M.T. Hauser & P.J. Hussey (2004). The Arabidopsis microtubule-associated protein AtMAP65-1: Molecular analysis of its microtubule bundling activity. Plant Cell 16(8): 2035-2047.
  • S. Muller, A. Smertenko, V. Wagner, M. Heinrich, P.J. Hussey & M.T. Hauser (2004). The plant microtubule-associated protein AtMAP65-3/PLE is essential for cytokinetic phragmoplast function. Current Biology 14(5): 412-417.
  • M.J. Deeks & P.J. Hussey (2003). Arp2/3 and 'The Shape of things to come'. Current Opinion in Plant Biology 6(6): 561-567.
  • J. Chan, G.J. Mao, A. Smertenko, P.J. Hussey, M. Naldrett, A. Bottrill & C.W. Lloyd (2003). Identification of a MAP65 isoform involved in directional expansion of plant cells. FEBS Letters 534(1-3): 161-163.
  • A.P. Smertenko, P.V. Bozhkov, L.H. Filonova, S. von Arnold & P.J. Hussey (2003). Re-organisation of the cytoskeleton during developmental programmed cell death in Picea abies embryos. Plant Journal 33(5): 813-824.
  • P.J. Hussey, E.G. Allwood & A.P. Smertenko (2002). Actin-binding proteins in the Arabidopsis genome database: properties of functionally distinct plant actin-depolymerizing factors/cofilins. Philosophical Transactions Of The Royal Society Of London Series B-Biological Sciences 357(1422): 791-798.
  • P.J. Hussey (2002). Cytoskeleton - Microtubules do the twist. Nature 417(6885): 128-129.
  • M.J. Deeks, P.J. Hussey & B. Davies (2002). Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Trends in Plant Science 7(11): 492-498.
  • D. Twell, S.K. Park, T.J. Hawkins, D. Schubert, R. Schmidt, A. Smertenko & P.J. Hussey (2002). MOR1/GEM1 has an essential role in the plant-specific cytokinetic phragmoplast. Nature Cell Biology 4(9): 711-714.
  • E.G. Allwood, R.G. Anthony, A.P. Smertenko, S. Reichelt, B.K. Drobak, J.H. Doonan, A.G. Weeds & P.J. Hussey (2002). Regulation of the pollen-specific actin-depolymerizing factor LIADF1. Plant Cell 14(11): 2915-2927.
  • P.J. Hussey, T.J. Hawkins, H. Igarashi, D. Kaloriti & A. Smertenko (2002). The plant cytoskeleton: recent advances in the study of the plant microtubule-associated proteins MAP-65, MAP-190 and the Xenopus MAP215-like protein, MOR1. Plant Molecular Biology 50(6): 915-924.
  • A. Moutinho, P.J. Hussey, A.J. Trewavas & R. Malho (2001). cAMP acts as a second messenger in pollen tube growth and reorientation. Proceedings of the National Academy of Sciences of the United States of America 98(18): 10481-10486.
  • R.A. Gungabissoon, S. Khan, P.J. Hussey & S.K. Maciver (2001). Interaction of elongation factor 1 alpha from Zea mays (ZmEF-1 alpha) with F-actin and interplay with the maize actin severing protein, ZmADF3. Cell Motility And The Cytoskeleton 49(2): 104-111.
  • A.P. Smertenko, E.G. Allwood, S. Khan, C.J. Jiang, S.K. Maciver, A.G. Weeds & P.J. Hussey (2001). Interaction of pollen-specific actin-depolymerizing factor with actin. Plant Journal 25(2): 203-212.
  • C. Lloyd & P. Hussey (2001). Microtubule-associated proteins in plants - Why we need a map. Nature Reviews Molecular Cell Biology 2(1): 40-47.
  • E.G. Allwood, A.P. Smertenko & P.J. Hussey (2001). Phosphorylation of plant actin-depolymerising factor by calmodulin-like domain protein kinase. FEBS Letters 499(1-2): 97-100.
  • P.J. Hussey & T.J. Hawkins (2001). Plant microtubule-associated proteins: the HEAT is off in temperature-sensitive mor1. Trends in Plant Science 6(9): 389-392.
  • A. Smertenko, N. Saleh, H. Igarashi, H. Mori, I. Hauser-Hahn, C.J. Jiang, S. Sonobe, C.W. Lloyd & P.J. Hussey (2000). A new class of microtubule-associated proteins in plants. Nature Cell Biology 2(10): 750-753.
  • C. Barroso, J. Chan, V. Allan, J. Doonan, P. Hussey & C. Lloyd (2000). Two kinesin-related proteins associated with the cold-stable cytoskeleton of carrot cells: characterization of a novel kinesin, DcKRP120-2. Plant Journal 24(6): 859-868.
  • R.G. Anthony, S. Reichelt & P.J. Hussey (1999). Dinitroaniline herbicide-resistant transgenic tobacco plants generated by co-overexpression of a mutant alpha-tubulin and a beta-tubulin. Nature Biotechnology 17(7): 712-716.
  • R.G. Anthony & P.J. Hussey (1999). Double mutation in Eleusine indica alpha-tubulin increases the resistance of transgenic maize calli to dinitroaniline and phosphorothioamidate herbicides. Plant Journal 18(6): 669-674.
  • R.G. Anthony, T.R. Waldin, J.A. Ray, S.W.J. Bright & P.J. Hussey (1998). Herbicide resistance caused by spontaneous mutation of the cytoskeletal protein tubulin. Nature 393(6682): 260-263.
  • R.A. Gungabissoon, C.J. Jiang, B.K. Drobak, S.K. Maciver & P.J. Hussey (1998). Interaction of maize actin-depolymerising factor with actin and phosphoinositides and its inhibition of plant phospholipase C. Plant Journal 16(6): 689-696.
  • P.J. Hussey, M. Yuan, G. Calder, S. Khan & C.W. Lloyd (1998). Microinjection of pollen-specific actin-depolymerizing factor, ZmADF1, reorientates F-actin strands in Tradescantia stamen hair cells. Plant Journal 14(3): 353-357.
  • A.P. Smertenko, C.J. Jiang, N.J. Simmons, A.G. Weeds, D.R. Davies & P.J. Hussey (1998). Ser6 in the maize actin-depolymerizing factor, ZmADF3, is phosphorylated by a calcium-stimulated protein kinase and is essential for the control of functional activity. Plant Journal 14(2): 187-193.
  • R.G. Anthony & P.J. Hussey (1998). Suppression of endogenous alpha and beta tubulin synthesis in transgenic maize calli overexpressing alpha and beta tubulins. Plant Journal 16(3): 297-304.
  • C.J. Jiang, A.G. Weeds, S. Khan & P.J. Hussey (1997). F-actin and G-actin binding are uncoupled by mutation of conserved tyrosine residues in maize actin depolymerizing factor (ZmADF). Proceedings of the National Academy of Sciences of the United States of America 94(18): 9973-9978.
  • C.J. Jiang, A.G. Weeds & P.J. Hussey (1997). The maize actin depolymerizing factor, ZmADF3, redistributes to the growing tip of elongating root hairs and can be induced to translocate into the nucleus with actin. Plant Journal 12(5): 1035-1043.
  • I. Lopez, R.G. Anthony, S.K. Maciver, C.J. Jiang, S. Khan, A.G. Weeds & P.J. Hussey (1996). Pollen specific expression of maize genes encoding actin depolymerizing factor-like proteins. Proceedings of the National Academy of Sciences of the United States of America 93(14): 7415-7420.

Supervises