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Staff Profile

Prof. Andrew Whiting - all publications

Journal Article

  • Pujol, Alba & Whiting, Andrew (2017). Double Diastereoselective Approach to Chiral syn- and anti-1,3-Diol Analogues through Consecutive Catalytic Asymmetric Borylations. The Journal of Organic Chemistry 82(14): 7265-7279.
  • Haffez, H., Khatib, T., McCaffery, P., Przyborski, S., Redfern, C. & Whiting, A. (2017). Neurogenesis in Response to Synthetic Retinoids at Different Temporal Scales. Molecular Neurobiology
  • Haffez, H., Chisholm, D. R., Valentine, R., Pohl, E., Redfern, C. & Whiting, A. (2017). The molecular basis of the interactions between synthetic retinoic acid analogues and the retinoic acid receptors. MedChemComm 8(3): 578-592.
  • Girling, P.R., Batsanov, A.S., Calow, A.D.J., Shen, H.C. & Whiting, A. (2016). Alternative tandem cyclisation pathways in the reaction between imines and enones. Tetrahedron 72(8): 1105-1113.
  • Chisholm, David R., Valentine, Roy, Pohl, Ehmke & Whiting, Andrew (2016). Conjugate Addition of 3-Buytn-2-one to Anilines in Ethanol: Alkene Geometric Insights through In Situ FTIR Monitoring. The Journal of Organic Chemistry 81(17): 7557-7565.
  • Chisholm, D. R., Zhou, G.-L., Pohl, E., Valentine, R. & Whiting, A. (2016). Practical synthetic strategies towards lipophilic 6-iodotetrahydroquinolines and -dihydroquinolines. Beilstein Journal of Organic Chemistry 12: 1851-1862.
  • Liu, S., Zhang, Q., Li, H., Yang, Y., Tiana, X. & Whiting, A. (2015). A visible light induced α-H chlorination of alkylarenes with inorganic chloride under nanoAg@AgCl. Chemistry: A European Journal 21(27): 9671-9675.
  • Chaiyaveij, D., Batsanov, A.S., Fox, M.A., Marder, T.B. & Whiting, A. (2015). An experimental and computational approach to understanding the reactions of acyl nitroso compounds in [4+2]-cycloadditions. The Journal of Organic Chemistry 80(19): 9518-9534.
  • Whiting, Andrew, Madden, Katrina S., David, Sylvain & Knowles, Jonathan P. (2015). Heck-Mizoroki Coupling of Vinyliodide and Applications in The Synthesis of Dienes and Trienes. Chemical Communications 51(57): 11409-11412.
  • Pujol, A., Calow, A. D. J., Batsanov, A. S. & Whiting, A. (2015). One-pot catalytic asymmetric borylation of unsaturated aldehyde-derived imines; functionalisation to homoallylic boronate carboxylate ester derivatives. Organic & Biomolecular Chemistry 13(18): 5122-5130.
  • Eberlin, Ludovic, Carboni, Bertrand & Whiting, Andrew (2015). Regioisomeric and substituent effects upon the outcome of the reaction of 1-borodienes with nitrosoarene compounds. The Journal of Organic Chemistry 80(13): 6574-6583.
  • Lopez-Real, R.E., Budge, J.J.R., Marder, T.B., Whiting, A., Hunt, P.N & Przyborski, S.A. (2014). Application of Synthetic Photostable Retinoids Induces Novel Limb and Facial Phenotypes During Chick Embryogenesis In Vivo. Journal of Anatomy 224(4): 392-411.
  • La Cascia, E., Sanz, X., Bo, C., Whiting, A. & Fernandez, E. (2014). Asymmetric metal free β-boration of α,β-unsaturated imines assisted by (S)-MeBoPhoz. Organic and Biomolecular Chemistry 13(5): 1328-1332.
  • Batsanov, A. S., Georgiou, I., Girling, P. R., Pommier, L., Shen, H. C. & Whiting, A. (2014). Asymmetric synthesis and application of homologous pyrroline-2-alkylboronic acids: Identification of the B-N distance for eliciting bifunctional catalysis of an asymmetric aldol reaction. Asian Journal of Organic Chemistry 3(4): 470-479.
  • Madden, K. S., Mosa, F. A. & Whiting, A. (2014). Non-isoprenoid polyene natural products - structures and synthetic strategies. Org. Biomol. Chem 12: 7877-7899.
  • Calow, A. D. J., Carbó, J. J., Cid, J., Fernández, E. & Whiting, A. (2014). Understanding α,β-unsaturated imine formation from amine additions to α,β-unsaturated aldehydes and ketones: an analytical and theoretical investigation. The Journal of Organic Chemistry 79(11): 5163-5172.
  • Tripoteau, F., Eberlin, L., Fox, M. A., Carboni, B. & Whiting, A. (2013). A novel, efficient synthesis of N-aryl pyrroles via reaction of 1-boronodienes with arylnitroso compounds. Chemical Communications 49(47): 5414-5416.
  • Calow, A. D. J., Batsanov, A. S., Pujol, A., Solé, C., Fernández, E. & Whiting, A. (2013). A selective transformation of enals into chiral γ-amino alcohols. Organic Letters 15(18): 4810-4813.
  • Calow, A. D. J., Solé, C., Whiting. A. & Fernández, E. (2013). Base-free β-boration of α,β-unsaturated imines catalysed by Cu2O with concurrent enhancement of asymmetric induction. ChemCatChem 5(8): 2233-2239.
  • Clemens, G., Flower, K.R., Gardner, P., Henderson, A. P., Knowles, J. P., Marder, T. B., Whiting, A. & Przyborski, S. A. (2013). Design and biological evaluation of synthetic retinoids: Probing length vs. stability vs. activity. Molecular BioSystems 9(12): 3124-3134.
  • Liu, S., Yang, Y., Liu, X., Ferdousi, F. K., Batsanov, A. S. & Whiting, A. (2013). Direct Amidation of Amino Acid Derivatives Catalyzed by Arylboronic Acids: Applications in Dipeptide Synthesis. European Journal of Organic Chemistry 2013(25): 5692-5700.
  • Ilyashenko, G., Al-Safadi, R., Donnan, R., Dubrovka, R., Pancholi, J., Watkinson, M. & Whiting, A. (2013). Facile synthesis of a 1,1’-desymmetrised ferrocene backbone and its one-pot double-“click” functionalisation. RSC Advances 3(38): 17081-17087.
  • Zhou, G.-L., Tams, D. M., Marder, T. B., Valentine, R., Whiting, A. & Przyborski, S. A. (2013). Synthesis and applications of 2,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development. Organic & Biomolecular Chemistry 11(14): 2323-2334.
  • Clemens, G., Flower, K. R., Henderson, A. P., Whiting, A., Przyborski, S. A., Jimenez-Hernandez, M., Ball, F., Bassan, P., Cinque, G. & Gardner, P. (2013). The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy. Molecular BioSystems 9(4): 677-692.
  • Girling, P.R., Batsanov, A.S., Shen, H.C. & Whiting, A. (2012). A multicomponent formal [1+2+2+1]-cycloaddition for the synthesis of dihydropyridines. Chemical Communications 48(40): 4893-4895.
  • I. Georgiou; & A. Whiting; (2012). An efficient enantioselective (R)-homoboroproline from (S)-proline using borylation approach. European Journal of Organic Chemistry 2012(22): 4110-4113.
  • Georgiou, I & Whiting, A (2012). Mechanism and optimisation of the homoboroproline bifunctional catalytic asymmetric aldol reaction: Lewis acid tuning through in situ esterification. Organic & Biomolecular Chemistry 10(12): 2422-2430.
  • A. D. J. Calow;, C. Solé;, E. Fernandez; & A. Whiting; (2012). Novel transformation of α,β-unsaturated aldehydes and ketones to γ-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence. Chemical Communications 48(93): 11401.
  • W. Na;, A. Messinis;, A. S. Batsanov;, Y. Zhen;, A. Whiting; & T. B. Marder; (2012). Palladium(II)-catalysed tandem cyclisation of electron-deficient aromatic enynes. Chemical Communications 48(80): 9986-9988.
  • S. Liu;, Y. Yang;, X. Zhen;, J. Li;, H. He; J. Feng; & A. Whiting; (2012). Stereoselective synthesis and rearrangement-fragmentation of arylidene N-alkoxydiketopiperazines. Organic & Biomolecular Chemistry 10(3): 663-670.
  • C. Solé;, A. Tatla;, J. Mata;, A. Whiting;, H. Gulyás; & E. Fernandez; (2011). Catalytic 1,3-difunctionalization of organic backbones via a highly stereoselective, one-pot, boron conjugate-addition/reduction/oxidation process. Chemistry - A European Journal 17(50): 14248.
  • Chaiyaveij, D, Cleary, L, Batsanov, AS , Marder, TB , Shea, KJ & Whiting, A (2011). Copper(II)-Catalyzed Room Temperature Aerobic Oxidation of Hydroxamic Acids and Hydrazides to Acyl-Nitroso and Azo Intermediates, and Their Diels_Alder Trapping. Organic Letters 13(13): 3442-3445.
  • Solé, C, Whiting, A, Gulyás, H & Fernández, E (2011). Highly Enantio- and Diastereoselective Synthesis of γ-Amino Alcohols from α,β-Unsaturated Imines through a One-Pot β-Boration/Reduction/Oxidation Sequence. Advanced Synthesis & Catalysis 353(2-3): 376-384.
  • J. P. Knowles;, V. E. O’Connor; & A. Whiting; (2011). Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues. Organic & Biomolecular Chemistry 9(6): 1876-1886.
  • Charville, H, Jackson, D, Hodges, G, Whiting, A & Wilson, MR (2011). The Uncatalyzed Direct Amide Formation Reaction – Mechanism Studies and the Key Role of Carboxylic Acid H-Bonding. European Journal of Organic Chemistry 2011(30): 5981-5990.
  • K. Aelvoet, A.S. Batsanov, A.J. Blatch, C. Grosjean, L.G.F. Patrick, C.A. Smethurst & A. Whiting (2008). A catalytic aldol reaction and condensation through in situ boron "ate"-complex enolate generation in water. Angewandte Chemie International Edition 47(4): 768-770.
  • Arnold, K, Davies, B, Hérault, D & Whiting, A (2008). Asymmetric Direct Amide Synthesis by Kinetic Amine Resolution: A Chiral Bifunctional Aminoboronic Acid Catalyzed Reaction between a Racemic Amine and an Achiral Carboxylic Acid. Angewandte Chemie International Edition 47(14): 2673-2676.
  • Arnold, K, Batsanov, AS , Davies, B, Grosjean, C, Schütz, T, Whiting, A & Zawatzkya, K (2008). The first example of enamine–Lewis acid cooperative bifunctional catalysis: application to the asymmetric Aldol reaction. Chemical Communications (33): 3879-3881.
  • D. Herault, K. Aelvoet, A.J. Blatch, A. Al-Majid, C.A. Smethurst & A. Whiting (2007). Benzimidazole nitrogen-directed, regiocontrolled, lithiation of ferrocenyl- and phenyl-N-n-butylbenzimidazoles. Journal of Organic Chemistry 72(1): 71-75.
  • A.S. Batsanov, J.P. Knowles & A. Whiting (2007). Mechanistic studies on the Heck-Mizoroki cross-coupling reaction of a hindered vinylboronate ester as a key approach to developing a highly stereoselective synthesis of a C1-C7 Z,Z,E-triene synthon for viridenomycin. Journal of Organic Chemistry 72(7): 2525-2532.
  • J.P. Knowles & A. Whiting (2007). The effects of ring size and substituents on the rates of acid-catalysed hydrolysis of five- and six-membered ring cyclic ketone acetals. European Journal of Organic Chemistry 2007(20): 3365-3368.
  • Mears, R.J., Sailes, H.E., Watts, J.P. & Whiting, A. (2006). A stereoselective remote homochiral boronate ester-mediated aldol reaction. Arkivoc 2006(1): 95-103.
  • Batsanov, A.S., Lightfoot, A.P., Twiddle, S.J.R. & Whiting, A. (2006). Bis(2,6-dimethylpyridyl)iodonium dibromoiodate. Acta crystallographica section E structure reports online E62: o901-o902.
  • Greenwell, H.C., Bowden, A.A., Chen, B.Q., Boulet, P., Evans, J.R.G., Coveney, P.V. & Whiting, A. (2006). Intercalation and in situ polymerization of poly(alkylene oxide) derivatives within M+-montmorillonite (M = Li, Na, K). Journal of Materials Chemistry 16(11): 1082-1094.
  • Blatch, A.J., Howard, J.A.K., Probert, M.R. & Whiting, A. (2006). N-(diphenylphosphinoyl)hydroxylamine. Acta crystallographica section E structure reports online 62(11): o5343-o5345.
  • Blatch, A.J., Howard, J.A.K., Probert, M.R., Smethurst, C.A. & Whiting, A. (2006). Potassium 4-nitrophenylsulfonate monohydrate. Acta crystallographica section E structure reports online 62(4): m741-m743.
  • A.J. Blatch, O.V. Chetina, J.A.K. Howard, L.G.F. Patrick, C.A. Smethurst & A. Whiting (2006). Synthesis and structure of bifunctional N-alkylbenzimidazole phenylboronate derivatives. Organic & Biomolecular Chemistry 4(17): 3297-3302.
  • Blatch, A.J., Howard, J.A.K., Probert, M.R., Smethurst, C.A. & Whiting, A. (2006). tert-Butyl N-(phosphino­yloxy)carbamate. Acta crystallographica section E structure reports online 62(11): o5346-o5348.
  • K. Arnold, B. Davies, R.L. Giles, C. Grosjean, G.E. Smith & A. Whiting (2006). To catalyze or not to catalyze? Insight into direct amide bond formation from amines and carboxylic acids under thermal and catalyzed conditions. Advanced Synthesis & Catalysis 348(7-8): 813-820.
  • Whiting, A. & Walton, S. (2006). Unexpected exothermic reaction between thioacetic acid and DMSO. Organic Process Research & Development 10(4): 846-846.
  • A. P. Lightfoot, S. J. R. Twiddle & A. Whiting (2005). 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane: An efficient and selective 2-carbon building block for vinylboronate Suzuki-Miyaura coupling reactions. Synlett (3): 529-531.
  • A. P. Lightfoot, S. J. R. Twiddle & A. Whiting (2005). A stereoselective synthesis of 1,6-diphenyl-1,3,5-hexatrienes utilising 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane as a two-carbon alkenyl building block. Organic & Biomolecular Chemistry 3(17): 3167-3172.
  • L. Di Bari, S. Guillarme, S. Hermitage, D. A. Jay, G. Pescitelli & A. Whiting (2005). Absolute stereochemistry assignment of N-phosphorylimine-derived aza-Diels-Alder adducts with TDDFF CD calculations. Chirality 17(6): 323-331.
  • J. D. Hamlin & A. Whiting (2005). An insight into the mechanism of the cellulose dyeing process, part 2: Simulation of aggregation, solvent and additive effects upon azo-linked aromatics and dyes. Molecular Simulation 31(8): 605-612.
  • H.C. Greenwell, M.J. Harvey, P.Boulet, A.A. Bowden, P.V. Coveney & A. Whiting (2005). Interlayer structure and bonding in nonswelling primary amine intercalated clays. Macromolecules 38(14): 6189-6200.
  • D. J. Berrisford, P. A. Lovell, N. R. Sulliman & A. Whiting (2005). Latent reactive groups unveiled through equilibrium dynamics and exemplified in crosslinking during film formation from aqueous polymer colloids. Chemical Communications 5904-5906.
  • B. Q. Chen, A. A. Bowden, H. C. Greenwell, P. Boulet, P. V. Coveney, A. Whiting & J. R. G. Evans (2005). Morphology and elastic modulus of novel poly oligo(ethylene glycol) diacrylate -montmorillonite nanocomposites. Journal of Polymer Science Part B-Polymer Physics 43(14): 1785-1793.
  • A. S. Batsanov, J. A. K. Howard, A. P. Lightfoot, S. J. R. Twiddle & A. Whiting (2005). Stereoselective chloro-deboronation reactions induced by substituted pyridine-iodine chloride complexes. European Journal of Organic Chemistry (9): 1876-1883.
  • S. W. Coghlan, R. L. Giles, J. A. K. Howard, L. G. F. Patrick, M. R. Probert, G. E. Smith & A. Whiting (2005). Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 2-N,N-diisopropylaminophenylboronate derivatives. Journal of Organometallic Chemistry 690(21-22): 4784-4793.
  • A. A. Bowden, A. Whiting, P. V. Coveney, J. R. G. Evans, H. C. Greenwell, P. Boulet & B. Q. Chen (2004). ATRP polymerized PEG-methyl ether methacrylatemontmorillonite nanocomposites. Abstracts of Papers of the American Chemical Society 228: U497-U497.
  • L. Di Bari, S. Guillarme, S. Hermitage, J. A. K. Howard, D. A. Jay, G. Pescitelli, A. Whiting & D. S. Yufit (2004). Lewis acid-catalysed aza-Diels-Alder versus Mannich reactions of N-diethyl phosphoryl imino dienophiles with oxygenated dienes and application of a chiral lewis acid. Synlett (4): 708-710.
  • S. Hermitage, J. A. K. Howard, D. Jay, R. G. Pritchard, M. R. Probert & A. Whiting (2004). Mechanistic studies on the formal aza-Diels-Alder reactions of N-aryl imines: evidence for the non-concertedness under Lewis-acid catalysed conditions. Organic & Biomolecular Chemistry 2(17): 2451-2460.
  • A. P. Lightfoot, S. J. R. Twiddle & A. Whiting (2004). On the mechanism and origin of the stereoselectivity in iodo-deboronation and chloro-deboronation of hindered alkenyl boronate esters using either ICI-NaOMe or ICI-pyridine. Tetrahedron Letters 45(46): 8557-8561.
  • G. N. Maw, C. Thirsk, J. L. Toujas, M. Vaultier & A. Whiting (2004). Preparation of an advanced phenylglycine-derived intermediate en route to the southern hemisphere tetraene of viridenomycin. Synlett (7): 1183-1186.
  • S. Guillarme & A. Whiting (2004). Unexpected temperature, time and solvent effects in the catalytic asymmetric aza-Diels-Alder reaction of an ethyl glyoxylate-derived N-aryl imine with Danishefsky's diene catalysed by a BINOL-zinc complex. Synlett (4): 711-713.
  • A. P. Lightfoot, G. Maw, C. Thirsk, S. J. R. Twiddle & A. Whiting (2003). 4,4,6-trimethyl-2-vinyl-1,3,2-dioxaborinane: a superior 2-carbon building block for vinylboronate Heck couplings. Tetrahedron Letters 44(41): 7645-7648.
  • A. Bundu, S. Guillarme, J. Hannan, H. L. Wan & A. Whiting (2003). A parallel combinatorial approach to locating homochiral Lewis acid catalysts for the asymmetric aza-Diels-Alder reaction of an imino dienophile (vol 39, pg 8905, 1998). Tetrahedron Letters 44(42): 7849-7850.
  • P. Boulet, A. A. Bowden, P. V. Coveney & A. Whiting (2003). Combined experimental and theoretical investigations of clay polymer nanocomposites: intercalation of single bifunctional organic compounds in Na+-montmorillonite and Na+-hectorite clays for the design of new materials. Journal of Materials Chemistry 13(10): 2540-2550.
  • R. L. Giles, J. A. K. Howard, L. G. F. Patrick, M. R. Probert, G. E. Smith & A. Whiting (2003). Synthesis and structure of potential Lewis acid-Lewis base bifunctional catalysts: 1-N,N-dimethylamino-8-borononaphthalene derivatives. Journal of Organometallic Chemistry 680(1-2): 257-262.
  • S. Pulacchini, K. F. Sibbons, K. Shastri, M. Motevalli, M. Watkinson, H. Wan, A. Whiting & A. P. Lightfoot (2003). Synthesis of C-2-symmetric aza- and azaoxa-macrocyclic ligands derived from (1R,2R)-1,2-diaminocyclohexane and their applications in catalysis. Dalton Transactions (10): 2043-2052.
  • A. P. Lightfoot, R. G. Pritchard, H. Wan, J. E. Warren & A. Whiting (2002). A novel scandium ortho-methoxynitrosobenzene-dimer complex: mechanistic implications for the nitroso-Diels-Alder reaction. Chemical Communications (18): 2072-2073.
  • K. R. Flower, J. D. Hamlin & A. Whiting (2002). An insight into the mechanism of the cellulose dyeing process, part 1: Modelling azo-systems in azo-linked aromatics and dyes. Molecular Simulation 28(12): 1031-1047.
  • S. Hermitage, D. A. Jay & A. Whiting (2002). Evidence for the non-concerted 4+2 -cycloaddition of N-aryl imines when acting as both dienophiles and dienes under Lewis acid-catalysed conditions. Tetrahedron Letters 43(52): 9633-9636.
  • A. Whiting, L. G. Patrick, R. L. Giles & S. W. Coghlan (2002). Modular bifunctional Lewis acid-Lewis base catalysts. Abstracts of Papers of the American Chemical Society 224: U185-U185.
  • A. Whiting & H. Wan (2002). New approaches to catalytic asymmetric nitroso diels-alder reactions. Abstracts of Papers of the American Chemical Society 224: U213-U213.
  • A. Whiting, H. Wan, A. P. Lightfoot & K. R. Flower (2002). New ruthenium based methods for the in situ generation of acyl nitroso dienophiles. Abstracts of Papers of the American Chemical Society 224: U184-U185.
  • D. A. Jay, A. Whiting, D. S. Yufit, J. A. K. Howard & S. Hermitage (2002). p-Tolylsulfonyl cyanide. Acta Crystallographica Section E-Structure Reports Online 58: o191-o193.
  • C. Thirsk & A. Whiting (2002). Polyene natural products. Journal of the Chemical Society-Perkin Transactions 1 (8): 999-1023.
  • A. A. Bowden, A. Whiting & P. V. Coveney (2002). Preparation and analysis of poly(oxyalkylene)-clay nanocomposites. Abstracts of Papers of the American Chemical Society 224: U492-U492.
  • L. G. F. Patrick & A. Whiting (2002). Synthesis of some polymerisable fluorescent dyes. Dyes and Pigments 55(2-3): 123-132.
  • K. R. Flower, A. P. Lightfoot, H. L. Wan & A. Whiting (2002). The development and application of ruthenium catalysed oxidations of a hydroxamic acid and in situ Diels-Alder trapping of the acyl nitroso derivative. Journal of the Chemical Society-Perkin Transactions 1 (18): 2058-2064.
  • D. Bosbach, P. V. Coveney, J. L. W. Griffin, A. Putnis, P. Risthaus, S. Stackhouse & A. Whiting (2002). The rational design, synthesis and demonstration of the recognition and binding of a diaza-dioxa-12-crown-4 diphosphonate macrocycle to all crystal growth faces of barium sulfate. Journal of the Chemical Society-Perkin Transactions 2 2(7): 1238-1245.
  • C. Thirsk, G. E. Hawkes, R. T. Kroemer, K. R. Liedl, T. Loerting, R. Nasser, R. G. Pritchard, M. Steele, J. E. Warren & A. Whiting (2002). The structure, modelling and dynamics of 2,7-diisopropoxy-1,8-diarylnaphthalenes. Journal of the Chemical Society-Perkin Transactions 2 (9): 1510-1519.
  • G. M. Brooke, N. R. Cameron, J. A. H. MacBride & M. C. Whiting (2002). The synthesis of oligomers related to poly(ethyleneglycol terephthalate). Polymer 43(4): 1139-1154.