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Centre for Sustainable Chemical Processes



R.F. Smith, S.C. Boothroyd, R.L. Thompson and E. Khosravi,
Green Chem. 2016: DOI: 10.1039/c5gc03075g.
This was picked up by Chemistry world/2016/03 and created a lot of interests from various companies and also the tyre and rubber recycling magazine (an article is coming out on this work). See


A Procedure for the Preparation and Isolation of Nucleoside-5’-Diphosphates
H. J. Korhonen, H. L. Bolt and D. R. W. Hodgson
Beilstein J. Org. Chem., 2015, 11, 469-472. DOI: doi:10.3762/bjoc.11.52.
The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein
P. D. Townsend, T. L. Rodgers, L. C. Glover, H. J. Korhonen, S. A. Richards, L. J. Colwell, E. Pohl, M. R. Wilson, D. R. W. Hodgson, T. C. B. McLeish and M. J. Cann
J. Biol. Chem., accepted expected to publish September 2015. DOI: 10.1074/jbc.M115.669267.
One-pot catalytic asymmetric borylation of unsaturated aldehyde-derived imines; functionalisation to homoallylic boronate carboxylate ester derivatives
A. Pujol, A. D. J. Calow, A. S. Batsanov and A. Whiting
Org. Biomol. Chem., 2015, 13, 5122-5130. DOI: 10.1039/c4ob02657h.
Heck–Mizoroki coupling of vinyliodide and applications in the synthesis of dienes and trienes
K.S.Madden, S. David, J.P. Knowles and A. Whiting
Chem. Commun., 2015, 51, 11409-11412. DOI: 10.1039/c5cc03273c.
Rate and equilibrium constants for the addition of N-heterocyclic carbenes into benzaldehydes: a remarkable 2-substituent effect
C. J. Collett, R. S. Massey, J. E. Taylor, O. R. Maguire, A. C. O'Donoghue and A. D. Smith
Angew. Chem. Int. Ed. 2015, 54, 6887-6892.
Proton transfer reactions of N-aryl triazolium salts: unusual ortho-substituent effects
D. E. Tucker, P. Quinn, R. S. Massey, C. J. Collett, D. J. Jasiewicz, C. R. Bramley, A. D. Smith and A. C. O'Donoghue
J. Phys. Org. Chem. 2015, 28, 108-115 (invited special issue contribution)
Understanding thio-effects in simple phosphoryl systems: role of solvent effects and nucleophile charge
A. T. P. Carvalho, A. C. O'Donoghue, D. R. W. Hodgson and S. C. L. Kamerlin
Org. Biomol. Chem. 2015, 13, 5391-5398
Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups
F. Joubert, G. J. Sharples, O. M. Musa, D. R. W. Hodgson and N. R. Cameron,
J. Polym. Sci. A Polym. Chem., 2015, 53, 68–78. DOI 10.1002/pola.27441.
Xanthates designed for the preparation of N-vinyl pyrrolidone-based linear and star architectures via RAFT polymerization.
I. J. Johnson, E. Khosravi, O. M. Musa, R. E. Simnett and A. M. Eissa,
J. Polym. Sci., Part A: Polym. Chem. 2015, in press, DOI:10.1002/pola.27502.
A monolith immobilised iridium Cp* catalyst for hydrogen transfer reactions under flow conditions
M. V. Rojo, L. Guetzoyan and I. R. Baxendale,
Org. Biomol. Chem. 2015, in press, DOI: 10.1039/c4ob02376e.
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance.
I. R. Baxendale, R. D. Braatz, B. K. Hodnett, K. F. Jensen, M. D. Johnson, P. Sharratt, J.-P. Sherlock amd A. J. Florence,
J. Pharm. Sci. 2015, in press, DOI: 10.1002/jps.24252.
Back Pressure Regulation of Slurry Forming Reactions in Continuous Flow.
B. J. Deadman, S. V. Ley, D. L. Browne, and I. R. Baxendale,
Chem. Eng. Tech. 2015, in press, DOI: 10.1002/ceat.201400445.R1.
PPN Pyrophosphate: A New Reagent For The Preparation Of Nucleoside-5’-Triphosphates,
H. J. Korhonen, H. L. Bolt, L. Vicente-Gines, D. C. Perks and D. R. W. Hodgson,
Phosphorus, Sulfur Silicon Relat. Elem., 2015, 190, 758-762. DOI: 10.1080/10426507.2014.984032.
Graft copolymers of hydroxyethyl cellulose by a ‘grafting to’ method: 15N labelling as a powerful characterisation tool in ‘click’ polymer chemistry,
F. Joubert, O. M. Musa, D. R. W. Hodgson and N. R. Cameron,
Polymer Chem., 2015, 6, 1567-1575. DOI:10.1039/C4PY01413H.
Quaternized diboron promotes catalytic borylation of a,b-unsaturated imines with (S)-MeBoPhoz assistance in the asymmetric induction,
E. La Cascia, X. Sanz, C. Bo, A. Whiting and E. Fernandez,
Org. Biomol. Chem., 2015, in press, DOI: 10.1039/C4OB02478H.
Sonogashira cross-coupling and homocoupling on a silver surface: Chlorobenzene and phenylacetylene on Ag(100),
C. Sanchez-Sanchez, N. Orozco, J. P. Holgado, S. K. Beaumont, G. Kyriakou, D. J. Watson, A. R. Gonzalez-Elipe, L. Feria, J. Fernández Sanz, and R. M. Lambert,
J. Am. Chem. Soc., 2015, 137, 940-947, DOI: 10.1021/ja5115584.


Asymmetric synthesis and application of homologous pyrroline-2-alkylboronic acids: Identification of the B-N distance for eliciting bifunctional catalysis of an asymmetric aldol reaction.
A. S. Batsanov, I. Georgiou, P. R. Girling, L. Pommier, H. C. Shen and A. Whiting,
Asian J. Org. Chem., 2014, 3, 470-479.
Understanding a,β-unsaturated imine formation from amine additions to a,β-unsaturated aldehydes and ketones – a spectroscopic and theoretical investigation.
A. D. J. Calow, J. J. Carbó, J. Cid, E. Fernández and A. Whiting,
J. Org. Chem., 2014, 79, 5163-5172.
Total synthesis of Fluoxetine & Duloxetine through an in situ imine formation/borylation/transimination and reduction approach,
A. D. J. Calow, E. Fernández and A. Whiting,
Org. Biomol. Chem., 2014, 12, 6121-6127.
Recent developments in the application of nanomaterials to understanding molecular level processes in cobalt catalysed Fischer-Tropsch synthesis, 
S. K. Beaumont,
Phys. Chem. Chem. Phys., 2014, 16, 5034-5043.
Combining in situ NEXAFS spectroscopy and CO2 methanation kinetics to study Pt and Co nanoparticle catalysts reveals key insights into the role of platinum in promoted cobalt catalysis,
S. K. Beaumont, S. Alayoglu, C. Specht, W. D. Michalak, V. V. Pushkarev, J. Guo, N. Kruse and G. A. Somorjai, 
J. Am. Chem. Soc.2014, 136, 9898-9901.
A nanoscale demonstration of hydrogen atom spill-over and surface diffusion across silica using the kinetics of CO2 methanation catalyzed on spatially separate Pt and Co nanoparticles,
S. K. Beaumont, S. Alayoglu, C. Specht, N. Kruse and G. A. Somorjai, 
Nano Lett., 2014, 14, 4792–4796. 
Boron-substituted 1,3-dienes and heterodienes as key elements in multicomponent processes,
L. Eberlin, B. Carboni and A. Whiting,
Beilstein J. Org. Chem., 2014, 10, 237-250.
Non-isoprenoid polyene natural products - structures and synthetic strategies,
K. S. Madden, F. A. Mosa and A. Whiting,
Org. Biomol. Chem., 2014, 12, 7877-7899.
Targeted fluorination of a non-steroidal anti-inflammatory drug to prolong metabolic half-life,
M. J. Shaughnessy, A. Harsanyi, J. Li, T. Bright, C. D. Murphy and G. Sandford,
ChemMedChem, 2014, 9, 733-736 .
A mild method for the synthesis of a novel dehydrobutyrine containing amino acid,
A. M. Webster, C. R. Coxon, A. M. Kenwright, G. Sandford and S. L. Cobb,
Tetrahedron, 201470, 4661-4667.
Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives.
G. Sandford R. Slater, D. S. Yufit, J. A. K. Howard and A. Vong,
J. Fluorine Chem., 2014167, 91-95.
Sustainable Synthesis of Thioimidazoles via Carbohydrate-Based Multicomponent Reactions.
M. Baumann and I. R. Baxendale,
Org. Lett. 2014, 16, 6076−6079.
Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations
M. Baumann, I. R. Baxendale, C. H. Hornung, S. V. Ley, M. V. Rojo, and K. A. Roper,
Molecules 2014, 19, 9736-9759.
A mild method for the synthesis of a novel dehydrobutyrine containing amino acid.
A. M. Webster, C. R. Coxon, A. M. Kenwright, G. Sandford, and S. L. Cobb,
Tetrahedron, 2014, 70, 4661–4667.
Iridium-catalyzed C-H borylation of pyridines.
S. A. Sadler, H. Tajuddin, I. A. I. Mkhalid, A. S. Batsanov, M. S. Cheung, A. C. Maxwell, L. Shukla, B. Roberts, D. Blakemore, Z. Lin, T. B. Marder and P. G. Steel,
Org. Biomol. Chem. 2014, 12, 7318 – 7327.
Zinc-catalyzed borylation of primary, secondary and tertiary alkyl halides with alkoxy diboron reagents at room temperature.
S. K. Bose, K. Fucke, L. Liu, P. G. Steel and T. B. Marder,
Angew. Chem. Int. Ed.,2014, 53, 1799-1803.
The first intramolecular silene Diels-Alder reactions.
M. Czyzewski, J. D. Sellars, T. Guliashvili, J. Tibbelin, Julius, L. Johnstone, J. Bower, M. Box, R. D. M. Davies, H. Ottosson, and P. G. Steel,
Chem. Commun.,2014, 50, 2919-2921.
Monomer sequencing and microstructural analysis on polymers of dimethyl norbornene dicarboxylate and 7-oxanorbornene dicarboxylic derivatives employing ruthenium catalyst by ROMP.
M. A. Tallon, Y. Rogan, B. Marie, R. Clark, O. M. Musa and E. Khosravi,
J. Polym. Sci., Part A: Polym. Chem. 2014, 52, 2477-2501.
The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions
F. Joubert, O.M. Musa, D.R.W. Hodgson and N.R. Cameron, 
Chem. Soc. Rev.2014, 7217-7235. DOI 10.1039/C4CS00053F
The aqueous N-phosphorylation and N-thiophosphorylation of aminonucleosides
L.P. Conway, R.J. Delley, J. Neville, G.R. Freeman, H.J. Maple, V. Chan, A.J. Hall and D.R.W. Hodgson, 
RSC Advances, 2014, 4, 38663-38671. DOI 10.1039/C4RA08317B
Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase
X. Zhai, Xiang, M. Go, A. C. O'Donoghue, T. L. Amyes, S. D. Pegan, Y. Wang, J. P. Loria, A. D. Mesecar, and J. P. Richard,
Biochemistry, 2014, 53, 3486-3501.DOI10.1021/bi500458t
Editorial Article.
A. C. O'Donoghue and L. C. Kamerlin,
Curr.Opin. Chem. Biol., 2014, pp. FM8-FM10. DOI: 10.1016/j.cbpa.2014.07.025.
Phosphate analogues in the dissection of mechanism. 
H.J. Korhonen, L.P. Conway and D.R.W. Hodgson,
Curr. Opin. Chem. Biol. 2014, 21, 63-72. DOI: 10.1016/j.cbpa.2014.05.001
Syntheses of fluoro-oxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester.
A. Harsanyi, G. Sandford, D.S. Yufit and J.A.K. Howard,
Beilstein J. Org. Chem. 2014, 10, 1213–1219. DOI: 10.3762/bjoc.10.119
Fluorotetrahydroquinolines from diethyl 2-fluoromalonate ester.
C.A. Fisher, A. Harsanyi, G. Sandford, D.S. Yufit and J.A.K. Howard,
CHIMIA 2014, 68, 425-429. DOI: 10.2533/chimia.2014.418
Pyrido[3,2-b][1,4]oxazine and pyrido[2,3-b][1,4]benzoxazine systems from tetrafluoropyridine derivatives. 
G. Sandford R. Slater, D.S. Yufit, J.A.K. Howard and A. Vong,
J. Fluorine Chem., 2014, 167, 91-95. DOI:10.1016/j.jfluchem.2014.05.003
2-Fluoromalonate esters : fluoroaliphatic building blocks for the life sciences.
A. Harsanyi and G. Sandford,
Org. Proc. Res. Dev., 2014, 18, 981-992. DOI: 10.1021/op500141c
Combined DFT and experimental studies of C–C and C–X elimination reactions promoted by a chelating phosphine–alkene ligand: the key role of penta-coordinate PdII
Laura Estévez, Luke W. Tuxworth, Jean-Marc Sotiropoulos, Philip W. Dyer and Karinne Miqueu
Dalton Trans., 2014, 43, 11165-11179. DOI: 10.1039/C4DT00340C 


The action of all-trans-retinoic acid (ATRA) and synthetic retinoid analogues (EC19 and EC23) on human pluripotent stem cells differentiation investigated using single cell infrared microspectroscopy, 
G. Clemens, K. R. Flower, A. P. Henderson, A. Whiting,  S. A. Przyborski,  M. Jimenez-Hernandez, F. Ball, P. Bassan, G. Cinque and P. Gardner, 
Mol. BioSyst.2013, 9, 677-692, DOI: 10.1039/C3MB25505K
Synthesis and applications of 1,4-disubstituted thiazoles derivatives as small molecule modulators of cellular development,
G.-L. Zhou, D. M. Tams, T. B. Marder, R. Valentine, S. A. Przyborski and A. Whiting, 
Org. Biomol. Chem.201311, 2323-2334, DOI:10.1039/C3OB00005B
Base-free β-boration of α,β-unsaturated imines catalysed by Cu2O with concurrent enhancement of asymmetric induction,
A. D. J. Calow, C. Solé, A. Whiting and E. Fernández, 
ChemCat Chem.20135, 2233–2239, DOI: 10.1002/cctc.201300113
A novel, efficient synthesis of N-aryl pyrroles via reaction of 1-boronodienes with arylnitroso compounds,
F. Tripoteau, L. Eberlin, M. A. Fox, B. Carboni and A. Whiting, 
Chem. Commun.2013, 49, 5414-5416, DOI:10.1039/C3CC42227E
Direct amidation of amino acids and synthesis of dipeptide using arylboronic acid as catalyst,
S. Liu,  Y. Yang,  X. Liu,  A. S. Batsanov and A. Whiting, 
Eur. J. Org. Chem.2013, 5692-5700, DOI: 10.1002/ejoc.201300560
 Facile synthesis of a 1,1’-desymmetrised ferrocene backbone and its one-pot double-“click” functionalisation,
G. Ilyashenko, R. Al-Safadi, R. Donnan, R. Dubrovka, J. Pancholi, M. Watkinson and A. Whiting, 
RSC Advances20133, 17081-17087, DOI: 10.1039/C3RA43054E
A selective transformation of enals into chiral gamma-amino alcohols,
A. D. J. Calow, A. S. Batsanov, A. Pujol, C. Solé, E. Fernández and A. Whiting, 
OrgLett201315, 4810-4813, DOI: 10.1021/ol4022029
Design and biological evaluation of synthetic retinoids: Probing length vs stability vs activity,
G. Clemens, K. R. Flower, P. Gardner, A. P. Henderson, J. P. Knowles, T. B. Marder, A. Whiting and S. A. Przyborski, 
Mol. BioSyst., 2013, 3124-3134, DOI: 10.1039/C3MB70273A
Continuous flow synthesis of difluoroamine systems by direct fluorination.
C.B. McPake, C.B. Murray and G. Sandford, 
Aust. J. Chem., 2013, 66, 145-150.
Pd catalysed sp2-sp Cross coupling reactions involving aromatic C-F bond activation.
M.R. Cargill, G. Sandford, P. Kilickiran and G. Nelles, 
Tetrahedron, 2013, 69, 512-516. 
A Convenient Chemical-Microbial Method for Developing Fluorinated Pharmaceuticals.
T. Bright, F. Dalton, V.L. Elder, C.D. Murphy, N. O’Connor and G. Sandford, 
Org. Biomol. Chem., 2013, 11, 1135-1142.
19F and 13C GIAO NMR shifts for the identification of perfluoro-quinoline and isoquinoline derivatives.
M.A. Fox, G. Pattison, G. Sandford, D.S. Yufit, A.S. Batsanov and J.A.K. Howard, 
J. Fluorine Chem., 2013, 155, 62-71.
Synthesis of a novel tetra-fluoropyridine containing amino acid.
A. Hudson, A. Hoose, G. Sandford and S.L. Cobb, 
Tetrahedron Lett., 2013, 54, 4865-4867.
Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes.
S. Mizuta, I, Stenhagen, M. O'Duill, J. Wolstenhulme, A. Kirjavainen, S. Forsback, M. Tredwell, G. Sandford, P. Moore, M. Huiban, S. Luthra, J. Passchier, O. Solin and V. Gouverneur, 
Org. Lett., 2013, 15, 2648-2651.
Asymmetric Electrophilic Fluorocyclization with Carbon Nucleophiles.
J.R. Wolstenhulme, J. Rosenqvist, O. Lozano, J. Ilupeju, N. Wurz, K.M. Engle, G.W. Pidgeon, P.R. Moore, G. Sandford, and V. Gouverneur, 
Angew. Chem. Intl. Ed. Engl., 2013, 52, 9796-9800. DOI: 10.1002/anie.201304845
Efficient Preparations of Fluorine Compounds. Edited by Herbert W. Roesky.
G. Sandford, 
ChemMedChem., 2013, 8, 1417. 
Exploring surface science and restructuring in reactive atmospheres of colloidally prepared bimetallic CuNi and CuCo nanoparticles on SiO2 in situ using ambient pressure X-ray photoelectron spectroscopy
S. K. Beaumont, S. Alayoglu, V. V. Pushkarev, Z. Liu, N. Kruse, G. A. Somorjai,
Faraday Discussions, 2013, 162, 31.
Surface Composition Changes of Redox Stabilized Bimetallic CoCu Nanoparticles Supported on Silica under H2 and O2 Atmospheres and During Reaction Between CO2 and H2: In situ X-ray Spectroscopic Characterization
S. Alayoglu, S. K. Beaumont, G. Melaet, A. E. Lindeman, N. Musselwhite, C. J. Brooks, M. A. Marcus, J. Guo, Z. Liu, N. Kruse, G. A. Somorjai,
J. Phys.Chem. C, 2013,117, 21803.
5′-Deoxy-5′-Hydrazinylguanosine as an Initiator of T7 Rna Polymerase-Catalyzed Transcriptions for the Preparation of Labeling-Ready RNAs.
M. Skipsey, G. Hack, T. A. Hooper, M. C. Shankey, L. P. Conway, M. Schröder and D. R. W. Hodgson,
Nucleosides, Nucleotides and Nucleic Acids, 2013, 32, 670-681.
Aqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.
M. Trmcic, F. L. Chadbourne, P. M. Brear, P. W. Denny, S. L. Cobb and D. R. W. Hodgson,
Org. Biomol. Chem., 2013, 11, 2660-2675.
Copper(II)–mediated thermolysis of alginates: A model kinetic study on the influence of metal ions in the thermochemical processing of macroalgae.
J. S. Rowbotham, P. W. Dyer, H. C. Greenwell, D. Selby and M. K. Theodorou,
Royal Society Interface, 2013, 3, 20120046
L. Li, J. S. Rowbotham, P. W. Dyer and H. C. Greenwell in An Introduction to Pyrolysis and Catalytic Pyrolysis: Versatile Techniques for Biomass Conversion, S. L. Suib, Ed., Elsevier, Netherlands, 2013.
A. C. O’Donoghue and R. S. Massey, Chapter 3, “Acid-Base Chemistry of Carbenes” in “Contemporary Carbene Chemistry”, Wiley (December 2013), Ed. Robert A. Moss, ISBN: 978-1-118-23795-3 (invited book chapter, 25 pages)
Substituent Effects on the Dehydration of Arene Hydrates in Aqueous Solution.
M. J. O’Mahony, R. A. More O’Ferrall, D. R. Boyd, C. M. Lam, A. C. O’Donoghue,
J. Phys. Org. Chem. 2013, 26, 989-996.
Young Career Focus: Dr. AnnMarie O’Donoghue (Durham University,UK).
M. Zanda and A. C. O’Donoghue,
Synthesis-Stuttgart, 2013, 45 (13), A89-90.
Mechanistic Insights into the Triazolylidene-catalysed Stetter and Benzoin Reactions: Role of the N-Aryl Substituent.
C. J. Collett, R. S. Massey, O. R. Maguire, A. S. Batsanov, A. C. O’Donoghue and A. D. Smith,
Chem. Sci., 2013, 4, 1514-1522.
An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles
M. Baumann, I. R. Baxendale,
Beilstein J. Org. Chem. 2013, 9, 2265–2319. DOI:10.3762/bjoc.9.265
The rapid generation of isothiocyanates in flow
M. Baumann, I. R. Baxendale,
Beilstein J. Org. Chem. 2013, 9, 1613–1619. DOI: 10.3762/bjoc.9.184
Studies of a Diastereoselective Electrophilic Fluorination Reaction Employing a Cryo-Flow Reactor
K. Nakayama, D. L. Browne, I.R. Baxendale, S. V. Ley,
Synlett 2013, 24, 1298–1302. DOI: 10.1055/s-0033-1338455
Flow chemistry approaches directed at improving chemical synthesis
I. R. Baxendale, C. J. Millia, L. Brocken,
Green Process Synth. 2013, 2, 211–230. DOI: 10.1515/gps-2013-0029
Flow Synthesis and Bio-Pharmacological Studies of a P2X7 Antagonist that Shows Analgesic Activity
C. Battilocchio, L. Guetzoyan, C. Cervetto, L. D. C. Mannelli, D. Frattaroli, I. R. Baxendale, G. Maura, L. Sautebin, M. Biava, C. Ghelardini, M. Marcoli, S. V. Ley,
A.C.S. Med. Chem. Lett. 2013, 4 (8), 704–709. DOI: 10.1021/ml400079h
The Synthesis of Neurotensin Antagonist SR 48692 for Prostate Cancer Research
 I. R. Baxendale, S. Cheung, M. O. Kitching, S. V. Ley, J. W. Shearman,
Bioorg. Med. Chem. 2013, 21, 4378–4387. DOI: 10.1016/j.bmc.2013.04.075
A Machine-Assisted Flow Synthesis of SR48692: a Probe for the Investigation of Neurotensin Receptor-1
C. Battilocchio, B. J. Deadman, N. Nikbin, M. O. Kitching, I. R. Baxendale, S. V. Ley,
Chem. Eur. J. 2013, 19, 7917–7930. DOI: 10.1002/chem.201300696
Synthesis of (–)-Hennoxazole A: Integrating Batch and Flow Chemistry Methods
A. Fernández, Z. G. Levine, M. Baumann, S. Sulzer-Mossé, C. Sparr, S. Schläger, A. Metzger, I. R. Baxendale, S. V. Ley,
Synlett 2013, 514–518. DOI: 10.1055/s-0032-1318109
The integration of flow reactors into synthetic organic chemistry
I. R. Baxendale,
J. Chem. Technol. Biotechnol.2013, 88, 519–552. DOI: 10.1002/jctb.4012
The Synthesis of Bcr-Abl Inhibiting Anticancer Pharmaceutical Agents Imatinib, Nilotinib and Dasatinib
B. J. Deadman, M. D. Hopkin,I.R. Baxendale, S. V. Ley,
Org. Biomol. Chem. 2013, 11, 1766–1800. DOI: 10.1039/c2ob27003j
An Expeditious Synthesis of Imatinib and Analogues Utilising Flow Chemistry Methods
M. D. Hopkin,I.R. Baxendale, S. V. Ley,
Org. Biomol. Chem. 2013, 11, 1822–1839. DOI: 10.1039/c2ob27002a
Flow Chemistry Synthesis of Zolpidem, Alpidem and other GABAA Agonists and their Biological Evaluation through the use of In-line Frontal Affinity Chromatography
L. Guetzoyan,N. Nikbin,I. R. Baxendale,S. V. Ley,
Chem. Sci. 2013, 4, 764–769. DOI: 10.1039/c2sc21850j


A multicomponent formal [1+2+2+1]-cycloaddition for the synthesis of dihydropyridines, 
P. R. Girling, A. S. Batsanov, H. C. Shen and A. Whiting, 
Chem. Commun., 2012, 48, 4893-4895, DOI:10.1039/C2CC31495A

An efficient enantioselective (R)-homoboroproline from (S)-proline using borylation approach,
I. Georgiou and A. Whiting, 
Eur. J. Org. Chem., 2012, 4110–4113, DOI: 10.1002/ejoc.201200652

Hydroformylation by Pt–Sn compounds from N-heterocyclic stannylenes,
B. M. Day, P. W. Dyer and M. P. Coles,
Dalton Trans., 2012, 41, 7457-7460 (DOI: 10.1039/C2DT30988B).

Thermochemical Processing of Macroalgae: A Late Bloomer in the Development of Third Generation Biofuels?,
J. S. Rowbotham, P. W. Dyer, H. C. Greenwell, M. K. Theodorou,
Biofuels, 2012, 3, 441-461 (DOI:10.4155/bfs.12.29).

Phosphine–alkene ligand-mediated alkyl–alkyl and alkyl–halide elimination processes from palladium(II)”,
L. Tuxworth, L. Baiget, A. Phanopoulos, O. J. Metters, A. S. Batsanov, M. A. Fox, J. A. K. Howard, and P. W. Dyer,
Chem. Commun., 2012, 48, 10413-10415, (DOI: 10.1039/C2CC35623F).

Application of molybdenum bis(imido) complexes in ethylene dimerisation catalysis,
W. R. H. Wright, A. S. Batsanov, A. M. Messinis, J. A. K. Howard, R. P. Tooze, M. J. Hanton, P. W. Dyer,
Dalton Transactions, 2012, 41, 5502-5511 (DOI: 10.1039/c2dt12061e).

Palladium(II)-catalyzed electron-deficient aromatic enyne electrophilic cyclization,
W. Na, A. Messinis, A. S. Batsanov, Y. Zhen, A. Whiting, and Todd B. Marder, 
Chem. Commun., 2012, 48, 9986 - 9988, DOI: 10.1039/C2CC35114E

Novel transformation of á,â-unsaturated aldehydes and ketones to ã-amino alcohols or 1,3-oxazines via a 4 or 5 step, one-pot sequence,
A. D. J. Calow, C. Solé, E. Fernandez and A. Whiting, 
Chem. Commun., 2012, 48, 11401-11403, DOI:10.1039/C2CC36129A 

R. J. Delley, S. Bandyopadhyay, M. A. Fox, C. Schliehe, D. R. W. Hodgson, F. Hollfelder, A. J. Kirby and A. C. O’Donoghue,
Org. Biomol. Chem., 2012, 10, 590.

Hydrolysis Studies of Phosphodichloridate and Thiophosphodichloridate Ions,
R. J. Delley, A. C. O’Donoghue and D. R. W. Hodgson,
J. Org. Chem., 2012, 5029.

A. C. O’Donoghue and R. S. Massey, Chapter 3 ‘Acid-Base Chemistry of Carbenes’, 27 pages, in ‘Contemporary Carbene Chemistry’, Wiley, Ed. R. A. Moss and M. P. Doyle.

Proton Transfer Reactions of Triazol-3-ylidenes,
R. S. Massey, C. J. Collett, A. G Lindsay, A. D. Smith , and A. C. O'Donoghue, 
J. Am. Chem. Soc., 2012, 134, 20421–20432.

Synthesis, structure and redox properties of tris(pyrazolyl)borate-capped ruthenium vinyl complexes,
J.D. Farmer, W.Y. Man, M.A. Fox, D.S. Yufit, J.A.K. Howard, A.F. Hill, P.J. Low,
J. Organomet. Chem., 2012, 173-185.

Synthesis, Redox Chemistry and Electronic Structure of the Butadiynyl and Hexatriynyl Complexes [Mo{(C≡C)n-C≡CR}(L2)(ç-C7H7)]z+ (n = 1 or 2; z = 0 or 1; R = SiMe or H; L = 2,2’-bipyridine or Ph2PCH2CH2PPh2),
H.N. Roberts, N.J. Brown, R. Edge, E.C. Fitzgerald, Y.T. Ta, D. Collison, P.J. Low, M.W. Whiteley,
Organometallics, 2012, 31, 6322-6335.
Some ruthenium complexes derived from propiolic esters: Facile decarboxylation of propiolic acid on a ruthenium center and related chemistry,
J.H. Bowie, M.I. Bruce, M.A. Buntine, A.S. Gentleman, D.C. Graham, P.J. Low, G.F. Metha, C. Mitchell, C.R. Parker, B.W. Skelton, A.H. White,
Organometallics, 2012, 31, 5262-5273.
Synthesis and characterization of dithia[3.3]paracyclophane bridged ruthenium vinyl and acetylide complexes,
J.-L. Xia, W.Y. Man, X. Zhu, C. Zhang, G.-J. Jin, P.A. Schauer, M.A. Fox, J. Yun, G.-A. Yu, P.J. Low, S.H. Liu,
Organometallics, 2012, 31, 5321-5333.
Synthesis, structure and electrochemical properties of triarylamine bridged dicobaltdicarbon tetrahedrane clusters,
W.Y. Man, K.B. Vincent, H.J. Spencer, D.S. Yufit, J.A.K. Howard, P.J. Low,
J. Cluster Sci., 2012, 23, 853-872 [invited contribution, R.D. Adams celebration issue].
Acetylene used as a new linker for molecular junctions in phenylene-ethynylene oligomer Langmuir-Blodgett films,
L.M. Ballesteros, S. Martín, M.C. Momblona, S. Marqués-González, M.C. Lopez, R.J. Nichols, P.J. Low, P. Cea,
J. Phys. Chem. C, 2012, 116, 9142 - 9150.
Experimental and theoretical studies on organic D-p-A systems containing 3-coordinate boron moieties as both p-donor and p-acceptor,
L. Weber, D. Eickhoff, V. Werner, T.B. Marder, M.A. Fox, P.J. Low, A.D. Dwyer, D.J. Tozer, S. Schwedler, A. Brockhinke, H.G. Stammler, B. Neumann,
Chem. Eur. J., 2012, 18, 1369 - 1382.
Substitution of tcne by ethynyl-metal complexes gives tricyanovinylethynyl (tricyanobutenynyl) derivatives: Synthesis, protonation and addition of metal-ligand fragments,
M.I. Bruce, M.A. Fox, P.J. Low, B.K. Nicholson, C.R. Parker, W.C. Patalinghug, B.W. Skelton, A.H. White,
Organometallics, 2012, 31, 2639-2657. (F.G.A. Stone memorial issue).

The synthesis, molecular and electronic structure of cyanovinylidene complexes,
E.M. Long, N.J. Brown, W.Y. Man, M.A. Fox, D.S. Yufit, J.A.K. Howard, P.J. Low,
Inorg. Chim. Acta, 2012, 380, 358-371.

Ligand redox non-innocence in transition metal s-alkynyl and related complexes,
P.A. Schauer, P.J. Low,
Eur. J. Inorg. Chem., 2012, 390 - 411.

Orbital symmetry control of electronic coupling in a symmetrical, all-carbon bridged ‘mixed valence’ compound: Synthesis, spectroscopy and electronic structure of [Mo(dppe)(h-C7H7)}2(m-C4)]n+ (n = 0, 1 or 2),
E.C. Fitzgerald, N.J. Brown, R. Edge, M. Helliwell, H.N. Roberts, F. Tuna, A. Beeby, D. Collison, P.J. Low, M.W. Whiteley,
Organometallics, 2012, 31, 157 - 169.

N. Colgin, N.J. Tatum, E. Pohl, S.L. Cobb and G. Sandford, 
J. Fluorine Chem., 2012, 133, 33-37.

C.B. McPake, C.B. Murray and G. Sandford, 
ChemSusChem., 2012, 5, 312-319.

G. Sandford 
Topics in Heterocyclic Chemistry, 2012, 27, 1-32.

G. Sandford, ‘ Synthesis by substitution of hydrogen (Update 2012)’ in Science of Synthesis. Knowledge Updates 2012/2, Thieme, Stuttgart, pp 491-498.

C.B. McPake and G. Sandford, 
Org. Proc. Res. Dev., 2012, 16, 844-851.

C.D. Murphy and G. Sandford, 
Chim. Oggi.,
2012, 30, 16-19.

M.A. Fox, G. Sandford, R. Slater, D.S. Yufit, J.A.K. Howard and A. Vong, 
J. Fluorine Chem.,
2012, 143, 148–154.

Patents 2012

V. Gouverneur and G. Sandford, Novel Chiral N-F Reagents, UK Pat Appl. GB1219819.8. November 5th 2012.

V. Gouverneur and G. Sandford, 2nd Generation Chiral N-F Reagents, UK Pat Appl. GB1219820.6. November 5th 2012.