Publication details for Prof. Graham SandfordHeeran, Darren & Sandford, Graham (2019). Multifunctional 2- and 3-fluoropyrroles. European Journal of Organic Chemistry 2019(13): 2339-2343.
- Publication type: Journal Article
- ISSN/ISBN: 1434-193X (print)
- DOI: 10.1002/ejoc.201900185
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Sequential reaction cascades for the synthesis of polysubstituted 2‐ and 3‐fluoropyrrole derivatives from common polybromopyrrole precursors have been developed. A strategic variation of a combination of regioselective debromolithiation followed by trapping of the corresponding carbanions by electrophilic fluorination and Pd catalysed cross coupling reactions allows access to polyfunctional fluoropyrrole products by methodology applicable to drug discovery programs, extending the range of five‐membered fluoroazaheteroaromatic derivatives potentially available for incorporation into screening libraries.