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Durham University

Department of Chemistry

Publication details for Prof. Graham Sandford

Heeran, Darren & Sandford, Graham (2019). Multifunctional 2- and 3-fluoropyrroles. European Journal of Organic Chemistry 2019(13): 2339-2343.

Author(s) from Durham


Sequential reaction cascades for the synthesis of polysubstituted 2‐ and 3‐fluoropyrrole derivatives from common polybromopyrrole precursors have been developed. A strategic variation of a combination of regioselective debromolithiation followed by trapping of the corresponding carbanions by electrophilic fluorination and Pd catalysed cross coupling reactions allows access to polyfunctional fluoropyrrole products by methodology applicable to drug discovery programs, extending the range of five‐membered fluoroazaheteroaromatic derivatives potentially available for incorporation into screening libraries.