Dr Kalesh Karunakaran
(email at firstname.lastname@example.org)
Kalesh Karunakaran completed his MSc in Chemistry at the Indian Institute of Technology (IIT), Madras. He then pursued his PhD (received 2010) in Chemical Biology with Professor Yao Shao Qin at the National University of Singapore (NUS). His thesis focussed on the development of chemical tools, mainly using the activity-based protein profiling (ABPP) approach and rapid assembly of chemical compound libraries using the modular “click chemistry” approach, for the studies of protein kinases and protein phosphatases. Following his PhD, he joined in the R&D division of Albany Molecular Research Inc. (AMRI) Singapore as a senior research scientist and worked on the Medicinal chemistry and Structure-Activity-Relationship (SAR) studies of a number of inhibitor lead compounds. After a brief stint in the pharma industry, in 2012 he switched back to academic research with a Marie Curie individual fellowship from the European Research Agency and joined the research group of Professor Ed Tate in the Department of Chemistry of Imperial College London. Here he focussed on the development of chemical probes for the profiling of post-translational modifications arginine methylation and lysine succinylation and development of a competition-based ‘spike-in’ SILAC-quantitative chemical proteomics method for the target profiling of pharmacologically active natural products. In 2015, he joined the proteomics & mass-spectrometry group of Dr Peter DiMaggio in the Department of Chemical Engineering of Imperial College to work on a GSK-funded Engineered Medicines Laboratory project. Here he developed novel MS-chemical proteomics technologies for the study of intracellular ADP-ribosylation in cancer cells. In January 2019 he joined the Department of Chemistry of Durham University as an Assistant Professor (Research – GCRF NTD Research Fellow). His research interest is in developing and applying chemical biology and chemical proteomics methods for identifying and validating new drug targets for Leishmaniasis and Chagas disease.
- Kalesh, Karunakaran, Lukauskas, Saulius, Borg, Aaron J., Snijders, Ambrosius P., Ayyappan, Vinay, Leung, Anthony K. L., Haskard, Dorian O. & DiMaggio, Peter A. (2019). An Integrated Chemical Proteomics Approach for Quantitative Profiling of Intracellular ADP-Ribosylation. Scientific Reports 9: 6655.
- Mantravadi, Pavan, Kalesh, Karunakaran, Dobson, Renwick, Hudson, André & Parthasarathy, Anutthaman (2019). The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies. Antibiotics 8(1): 8.
- Wong, Yin Kwan, Xu, Chengchao, Kalesh, Karunakaran A., He, Yingke, Lin, Qingsong, Wong, W. S. Fred, Shen, Han-Ming & Wang, Jigang (2017). Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action. Medicinal Research Reviews 37(6): 1492.
- Clulow, James A., Storck, Elisabeth M., Lanyon-Hogg, Thomas, Kalesh, Karunakaran A., Jones, Lyn H. & Tate, Edward W. (2017). Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications 53(37): 5182-5185.
- Ong, Yong Siang, Gao, Liqian, Kalesh, Karunakaran A., Yu, Zhiqiang, Wang, Jigang, Liu, Chengcheng, Li, Yiwen, Sun, Hongyan & Lee, Su Seong (2017). Recent Advances in Synthesis and Identification of Cyclic Peptides for Bioapplications. Current Topics in Medicinal Chemistry 17(20).
- Parthasarathy, Anutthaman, Anandamma, Sasikala K. & Kalesh, Karunakaran A. (2017). The Medicinal Chemistry of Therapeutic Peptides: Recent Developments in Synthesis and Design Optimizations. Current Medicinal Chemistry 24.
- Wang, Jianhao, Zhang, Chencheng, Liu, Li, Kalesh, Karunakaran A., Qiu, Lin, Ding, Shumin, Fu, Minli, Gao, Li-qian & Jiang, Pengju (2016). A capillary electrophoresis method to explore the self-assembly of a novel polypeptide ligand with quantum dots. ELECTROPHORESIS 37(15-16): 2156.
- Cioffi, Christopher L., Liu, Shuang, Wolf, Mark A., Guzzo, Peter R., Sadalapure, Kashinath, Parthasarathy, Visweswaran, Loong, David T. J., Maeng, Jun-Ho, Carulli, Edmund, Fang, Xiao, Karunakaran, Kalesh, Matta, Lakshman, Choo, Sok Hui, Panduga, Shailijia, Buckle, Ronald N., Davis, Randall N., Sakwa, Samuel A., Gupta, Priya, Sargent, Bruce J., Moore, Nicholas A., Luche, Michele M., Carr, Grant J., Khmelnitsky, Yuri L., Ismail, Jiffry, Chung, Mark, Bai, Mei, Leong, Wei Yee, Sachdev, Nidhi, Swaminathan, Srividya & Mhyre, Andrew J. (2016). Synthesis and Biological Evaluation of N-(1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1. Journal of Medicinal Chemistry 59(18): 8473.
- Wang, Jigang, Gao, Liqian, Lee, Yew Mun, Kalesh, Karunakaran A., Ong, Yong Siang, Lim, Jaehong, Jee, Joo-Eun, Sun, Hongyan, Lee, Su Seong, Hua, Zi-Chun & Lin, Qingsong (2016). Target identification of natural and traditional medicines with quantitative chemical proteomics approaches. Pharmacology & Therapeutics 162: 10.
- Tate, Edward W, Kalesh, Karunakaran A, Lanyon-Hogg, Thomas, Storck, Elisabeth M & Thinon, Emmanuelle (2015). Global profiling of protein lipidation using chemical proteomic technologies. Current Opinion in Chemical Biology 24: 48.
- Kalesh, Karunakaran A., Clulow, James A. & Tate, Edward W. (2015). Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics. Chemical Communications 51(25): 5497.
- Kalesh, Karunakaran A. & Tate, Edward W. (2014). A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5. Org. Biomol. Chem 12(25): 4310.
- Prasannan, Remya, Kalesh, Karunakaran A., Shanmugam, Muthu K., Nachiyappan, Alamelu, Ramachandran, Lalitha, Nguyen, An H., Kumar, Alan Prem, Lakshmanan, Manikandan, Ahn, Kwang Seok & Sethi, Gautam (2012). Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer. Biochemical Pharmacology 84(10): 1268.
- Sasikala, K.A., Kalesh, K.A., Anabha, E.R., Pillai, P. Madhavan, Asokan, C.V. & Devaky, K.S. (2011). Synthesis of 2,3,5-trisubstituted furans from α-formylaroylketene dithioacetals. Tetrahedron Letters 52(14): 1667.
- Kalesh, Karunakaran A., Tan, Lay Pheng, Lu, Kai, Gao, Liqian, Wang, Jigang & Yao, Shao Q. (2010). Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs). Chem. Commun 46(4): 589.
- Kalesh, Karunakaran A., Sim, Derek S. B., Wang, Jigang, Liu, Kai, Lin, Qingsong & Yao, Shao Q. (2010). Small molecule probes that target Ablkinase. Chem. Commun 46(7): 1118.
- Kalesh, Karunakaran A., Shi, Haibin, Ge, Jingyan & Yao, Shao Q. (2010). The use of click chemistry in the emerging field of catalomics. Organic & Biomolecular Chemistry 8(8): 1749.
- Tan, Lay Pheng, Wu, Hao, Yang, Peng-Yu, Kalesh, Karunakaran A., Zhang, Xiaohua, Hu, Mingyu, Srinivasan, Rajavel & Yao, Shao Q. (2009). High-Throughput Discovery ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry. Organic Letters 11(22): 5102.
- Srinivasan, Rajavel, Tan, Lay Pheng, Wu, Hao, Yang, Peng-Yu, Kalesh, Karunakaran A. & Yao, Shao Q. (2009). High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening. Organic & Biomolecular Chemistry 7(9): 1821.
- Kalesh, Karunakaran A., Liu, Kai & Yao, Shao Q. (2009). Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry. Organic & Biomolecular Chemistry 7(24): 5129.
- Liu, Kai, Kalesh, Karunakaran A., Bing Ong, Li & Yao, Shao Q. (2008). An Improved Mechanism-Based Cross-Linker for Multiplexed Kinase Detection and Inhibition in a Complex Proteome. ChemBioChem 9(12): 1883.
- Kalesh, Karunakaran A., Yang, Peng-Yu, Srinivasan, Rajavel & Yao, Shao Qin (2007). Click Chemistry as a High-Throughput Amenable Platform in Catalomics. QSAR & Combinatorial Science 26(11-12): 1135.
- Srinivasan, Rajavel, Li, Junqi, Ng, Su Ling, Kalesh, Karunakaran A & Yao, Shao Q (2007). Methods of using click chemistry in the discovery of enzyme inhibitors. Nature Protocols 2(11): 2655.
- Nair, A. Sreekumaran, Subramaniam, Chandramouli, Rosemary, M. J., Tom, Renjis T., Kumar, V. R. Rajeev, Singh, D. M. David Jeba, Cyriac, Jobin, Jain, Prashant, Kalesh, K. A., Bhattacharya, Shreya & Pradeep, T. (2005). Nanoparticles-chemistry, new synthetic approaches, gas phase clustering and novel applications. Pramana 65(4): 631.