Publication details for Prof Roy Andrew QuinlanForssell-Aronsson, E. & Quinlan, R.A. (2017). The impact of circadian rhythms on medical imaging and radiotherapy regimes for the paediatric patient. Radiation Protection Dosimetry 173(1-3): 16-20.
- Publication type: Journal Article
- ISSN/ISBN: 0144-8420, 1742-3406
- DOI: 10.1093/rpd/ncw328
- Further publication details on publisher web site
- Durham Research Online (DRO) - may include full text
Author(s) from Durham
Daily rhythmic changes are found in cellular events in cell cycle, DNA repair, apoptosis and angiogenesis in both normal and tumour tissue, as well as in enzymatic activity and drug metabolism. In this paper, we hypothesize that circadian rhythms need to be considered in radiation protection and optimization in personalized medicine, especially for paediatric care. The sensitivity of the eye lens to ionizing radiation makes the case for limiting damage to the lens epithelium by planning medical radio-imaging procedures for the afternoon, rather than the morning. Equally, the tumour and normal tissue response to radiotherapy is also subject to diurnal variation enabling optimization of time of treatment.