Animal Cells and Systems
We are a grouping of animal biologists working on a range of fundamental biological questions, most of which underpin biomedical interests relevant to the bioeconomy.
Our research ranges from the subcellular level to the whole animal system and is divided into three thematic areas:
Mechanisms of development and ageing - including stem cell biology and age related disease
Cell to system organization and function – focusing on the cytoskeleton, membrane biology and signalling from subcellular to whole animal systems
Cell and tissue biotechnology – incorporating tissue engineering, development and application of in vitro models and biomarkers of health and disease
As a group our fundamental strengths are in basic bioscience and biotechnology using a variety of platform technologies from tissue culture to model organisms. We develop and use a range of state-of-the-art technologies including advanced bioimaging, omics-based approaches and computational strategies. Through interdisciplinary research we have and encourage strong links with other science and medical disciplines within our faculty and with external national and international organisations. These include major corporate industries, HE Institutes and NHS Trusts to develop the medical applications of our research and the fundamental knowledge it delivers. This enables us to realise the value and impact of our fundamental research in the health and wellbeing of our society.
Academic Members: Dr Carrie A. Ambler, Dr R Bashir, Dr Adam Benham, Dr P Chazot, Dr Rebecca Clark, Dr David Doupe, Dr Martin Goldberg, Dr N Hole, Dr Paul Hunt, Prof CAB Jahoda, Dr Akis (Iakowos) Karakesisoglou, Dr Arto Maatta, Dr AJ O'Sullivan, Prof Stefan Przyborski, Dr S Pyner, Prof Roy Andrew Quinlan, Dr David Weinkove
Affiliates: Dr Martin Schröder, Dr Paul Yeo, Dr Sushma Grellscheid, Dr Paul Denny
Publications by staff in this group
- Cliffe, Adam, Doupé, David P., Sung, HsinHo, Lim, Isaac Kok Hwee, Ong, Kok Haur, Cheng, Li & Yu, Weimiao (2017). Quantitative 3D analysis of complex single border cell behaviors in coordinated collective cell migration. Nature Communications 8: 14905.
- Resnik-Docampo, Martin, Koehler, Christopher L., Clark, Rebecca I., Schinaman, Joseph M., Sauer, Vivien, Wong, Daniel M., Lewis, Sophia, D’Alterio, Cecilia, Walker, David W. & Jones, D. Leanne (2017). Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nature Cell Biology 19(1): 52-59.
- Li, Z., Hodgkinson, T., Gothard, E.J., Boroumand, S., Lamb, R., Cummins, I., Narang, P., Sawtell, A., Coles, J., Leonov, G., Reboldi, A., Buckley, C.D., Cupedo, T., Siebel, C., Bayat, A., Coles, M.C. & Ambler, C.A. (2016). Epidermal Notch1 recruits RORgamma+ group 3 innate lymphoid cells to orchestrate normal skin repair. Nature Communications 7: 11394.
- Virk, B., Jia, J., Maynard, C.A., Raimundo, A., Lefebvre, J., Richards, S.A., Chetina, N., Liang, Y., Helliwell, N., Cipinska, M. & Weinkove, D. (2016). Folate acts in E. coli to accelerate C. elegans aging independently of bacterial biosynthesis. Cell Reports 14(7): 1611-1620.
- Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W. & Walker, D. W. (2015). Distinct shifts in microbiota composition during Drosophila aging impair intestinal function and drive mortality. Cell Reports 12(10): 1656-1667.
- Hill, D.S., Robinson, N.D.P., Caley, M.P., Chen, M., O'Toole, E.A., Armstrong, J.L., Przyborski, S. & Lovat, P.E. (2015). A novel fully-humanised 3D skin equivalent to model early melanoma invasion. Molecular Cancer Therapeutics 14(11): 2665-2673.
- Quinlan, R.A. (2015). A new dawn for cataracts. Science 350(6261): 636-637.
- Fiserova, J., Spink, M., Richards, S.A., Saunter, C. & Goldberg, M.W. (2014). Entry into the nuclear pore complex is controlled by a cytoplasmic exclusion zone containing dynamic GLFG-repeat nucleoporin domains. Journal of Cell Science 127: 124-136.
- Cartwright, S. & Karakesisoglou, I. (2014). Nesprins in health and disease. Seminars in Cell and Developmental Biology 29: 169-179.
- Defour, A., van der Meulen, J.H., Bhat, R., Bigot, A., Bashir, R., Nagaraju, K. & Jaiswal, J.K. (2014). Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion. Cell Death and Disease 5(6): e1306.