Wolfson Fellow

Dr I Karakesisoglou

(email at iakowos.karakesisoglou@durham.ac.uk)

Biography

Bsc: 1993 University of Athens, Greece
PhD: 1996 Ludwig-Maximilians University Munich, Germany
Postdoctoral fellow: 1997-2002 University of Chicago, USA
Group leader: 2002-2007 University of Cologne, Germany
Senior Lecturer: 2007-present University of Durham, UK

Research Interests

Cytoskeleton Linker Proteins (Nesprins and Spectraplakins)
Nuclear Envelope Structure and Function
Premature and Physiological Ageing
Laminopathies
Tissue and Animal Morphogenesis

Research Groups

School of Biological and Biomedical Sciences

• Cell Structure
• Development and Regeneration
• Durham Centre for Bioimaging Technology

Publications

Journal papers: academic

• Taranum, S., Sur, I., Muller, R., Lu, W. Rashmi, R.N. Munch, M., Neumann, S., Karakesisoglou, I. & Noegel, A.A. (2012). Cytoskeletal interactions at the nuclear envelope mediated by Nesprins. International Journal of Cell Biology 2012: 736524.
• Taranum, S., Vaylann, E., Meinke, P., Abraham, S., Yang, L., Neumann, S., Karakesisoglou, I., Wehnert, M. & Noegel, A.A. (2012). LINC complex alterations in DMD and EDMD/CMT fibroblasts. European Journal of Cell Biology 91(8): 614-628.
• Lu, W,, Schneider,M,, Neumann, S,, Jaeger, V-M, Taranum, S,, Munck, M,, Cartwright, S,, Richardson, C,, Carthew, J,, Noh, K,, Goldberg, M,, Noegel, A, & Karakesisoglou, I. (2012). Nesprin interchain associations control nuclear size. Cellular and Molecular Life Sciences 69(20): 3493-3509.
• Rashmi R.N., Eckes B., Glöckner G., Groth M., Muller R., Munck M., Neumann S., Gloy J., Sellin L., Walz G., Schneider M., Karakesisoglou I., Eichinger L. & Noegel A.A. (2012). Roles for nuclear envelope associated Nesprin-2 Giant in cell differentiation, proliferation and chromatin association in a mouse model. Nucleus 3(2): 172-186.
• Schneider, M., Lu, W., Neumann, S., Brachner, A., Gotzmann, J., Noegel, A.A. & Karakesisoglou, I. (2011). Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cellular and Molecular Life Sciences 68(9): 1593-1610.
• Zwerger, M., Kolb, T., Richter, K., Karakesisoglou, I. & Herrmann, H. (2010). Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7. Molecular Biology of the Cell 21(2): 354-368.
• Neumann, S., Schneider, M., Daugherty, R.L., Gottardi, C.J., Eming, S., Beijer, A., Noegel, A.A. & Karakesisoglou, I. (2010). Nesprin-2 interacts with α-Catenin and regulates Wnt signaling at the nuclear envelope. Journal of Biological Chemistry 285(45): 34932-34938.
• A.L. Olins, T.V. Hoang, M. Zwerger, H. Herrmann, H. Zentgraf, A.A. Noegel, I. Karakesisoglou, D. Hodzic & D.E. Olins (2009). The LINC-less granulocyte nucleus. Eur J Cell Biol 88(4): 203-14.
• W. Stoffel, B. Holz, B. Jenke, E. Binczek, R.H. Gunter, C. Kiss, I. Karakesisoglou, M. Thevis, A.A. Weber, S. Arnhold & K. Addicks (2008). Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. EMBO Journal 27(17): 2281-2292.
• M. Schneider, A.A. Noegel & I. Karakesisoglou (2008). KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope. Biochem Soc Trans 36(Pt 6): 1368-72.
• Y. Luke, H. Zaim, I. Karakesisoglou, V.M. Jaeger, L. Sellin, W. Lu, M. Schneider, S. Neumann, A. Beijer, M. Munck, V.C. Padmakumar, J. Gloy, G. Walz & A.A. Noegel (2008). Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. Journal of Cell Science 121(11): 1887-1898.
• W. Lu, J. Gotzmann, L. Sironi, V.M. Jaeger, M. Schneider, Y. Luke, M. Uhlen, C.A. Szigyarto, A. Brachner, J. Ellenberg, R. Foisner, A.A. Noegel & I. Karakesisoglou (2008). Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta 1783(12): 2415-26.
• V. Peche, S. Shekar, M. Leichter, H. Korte, R. Schroder, M. Schleicher, T.A. Holak, C.S. Clemen, Y.B. Ramanath, G. Pfitzer, I. Karakesisoglou & A.A. Noegel (2007). CAP2, cyclase-associated protein 2, is a dual compartment protein. Cell Mol Life Sci 64(19-20): 2702-15.
• S. Kandert, Y. Luke, T. Kleinhenz, S. Neumann, W. Lu, V.M. Jaeger, M. Munck, M. Wehnert, C.R. Muller, Z. Zhou, A.A. Noegel, M.C. Dabauvalle & I. Karakesisoglou (2007). Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. Human Molecular Genetics 16(23): 2944-2959.
• Libotte, T., Zaim, H., Abraham, S., Padmakumar, V. C., Schneider, M., Lu, W. S., Munck, M., Hutchison, C., Wehnert, M., Fahrenkrog, B., Sauder, U., Aebi, U., Noegel, A. A. & Karakesisoglou, I. (2005). Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Molecular Biology of the Cell 16(7): 3411-3424.
• Padmakumar, V. C., Libotte, T., Lu, W. S., Zaim, H., Abraham, S., Noegel, A. A., Gotzmann, J., Foisner, R. & Karakesisoglou, I. (2005). The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Journal of Cell Science 118(15): 3419-3430.
• V.C. Padmakumar, S. Abraham, S. Braune, A.A. Noegel, B. Tunggal, I. Karakesisoglou & E. Korenbaum (2004). Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 295(2): 330-9.
• Kodama, A., Karakesisoglou, I., Wong, E., Vaezi, A. & Fuchs, E. (2003). ACF7: An essential integrator of microtubule dynamics. Cell 115(3): 343-354.
• Fuchs, E. & Karakesisoglou, I. (2001). Bridging cytoskeletal intersections. Genes & Development 15(1): 1-14.
• Karakesisoglou, I., Yang, Y. M. & Fuchs, E. (2000). An epidermal plakin that integrates actin and microtubule networks at cellular junctions. Journal Of Cell Biology 149(1): 195-208.
• Lee, S. S., Karakesisoglou, I., Noegel, A. A., Rieger, D. & Schleicher, M. (2000). Dissection of functional domains by expression of point-mutated profilins in Dictyostelium mutants. European Journal Of Cell Biology 79(2): 92-103.
• Karakesisoglou, I., Janssen, K. P., Eichinger, L., Noegel, A. A. & Schleicher, M. (1999). Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue. Journal Of Cell Biology 145(1): 167-181.
• U. Gottwald, R. Brokamp, I. Karakesisoglou, M. Schleicher & A.A. Noegel (1996). Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin. Mol Biol Cell 7(2): 261-72.
• Karakesisoglou, I., Schleicher, M., Gibbon, B. C. & Staiger, C. J. (1996). Plant profilins rescue the aberrant phenotype of profilin-deficient Dictyostelium cells. Cell Motility And The Cytoskeleton 34(1): 36-47.
• M. Schleicher, B. Andre, C. Andreoli, L. Eichinger, M. Haugwitz, A. Hofmann, J. Karakesisoglou, M. Stockelhuber & A.A. Noegel (1995). Structure/function studies on cytoskeletal proteins in Dictyostelium amoebae as a paradigm. FEBS Lett 369(1): 38-42.
• M. Haugwitz, A.A. Noegel, J. Karakesisoglou & M. Schleicher (1994). Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell 79(2): 303-14.