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Dr Muhammad Ayub

Honorary Clinical Senior Lecturer in Psychiatric Genetics in the Mental Health Research Centre

Fellow of the Wolfson Research Institute for Health and Wellbeing

Biography

Dr Muhammad Ayub graduated in 1985 from Nishtar Medical College, Multan Pakistan. He had his initial training in Psychiatry in Mayo Hospital Lahore. He then Joined Edinburgh Rotational Training Scheme in Psychiatry in 1991. He moved to Lahore to take the post of assistant professor in Psychiatry in 1996. This position involved provision of training to under and post graduate doctors in Psychiatry.

He is currently is consultant psychiatrist in Learning Disability Service in Tees, Esk and Wear Valleys NHS Foundation Trust.

During his stay in Lahore he developed an interest in research in genetics of mental disorders and Intellectual Disability. His other areas of research are psychological consequences of trauma and measurement of psychopathology across cultural boundaries.

Research Groups

Medicine, Pharmacy and Health, School of

Mental Health Research Centre

Selected Publications

Books: authored

Naeem, F., Saeed, A., Zaidi, Q. & Ayub, M. (2008). Urdu Translation of International Classification of Diseases (ICD10): Research Diagnostic Criteria for Psychistric Disorders (RDC). Lahore, Pakistan: Lahore Institute of Research and Development.
Chaudhry, H. R. (Ed), Naeem, F. (Ed), Iqbal, M., Mufti, K. & Ayub, M. (2005). Handbook of Recognition and Management of Depression. Pakistan Psychiatric Research Centre.
Naeem, F. (Ed), Chaudhry, H. R., Ayub, M. & Mujtaba, M. (2004). Internet for doctors in developing countries. Glaxo Smith Kline.

Books: sections

Ayub, M., Noor, A. & Vincent, J. B. (2013). The Role of the Latent TGF-β Binding Protein 3, LTBP3, in Oligodontia and Bone Density Abnormality. In Inborn errors of Development.
Kaufman, L., Noor, A., Ayub, M. & Vincent, J. B. (2011). Common Genetic Etiologies and Biological Pathways Shared Between Autism Spectrum Disorders and Intellectual Disabilities. In Autism Spectrum Disorders: The Role of Genetics in Diagnosis and Treatment. Deutsch, S. InTech. 125-158.

Journal papers: academic

Mushtaq, I., Ayub, M., Mushtaq, S., Adnan Hafeez, M., Helal, N., Irfan, M., Hassan, B., Tiffin, P. A. & Naeem, F. (Accepted). Domestic Violence, Mental Illness and Suicidal Ideation- A study from Lahore, Pakistan. Journal of Mental Health
Ayub, M., Irfan, M., Maclean, A., Naeem, F. & Blackwood, D. (2013). Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9†‡. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 162(2): 157-162.
Vincent, A. K., Noor, A., Janson, A., Minassian, B. A., Ayub, M., Vincent, J. B. & Morel, C.F. (2012). You have full text access to this content Identification of genomic deletions spanning the PCDH19 gene in two unrelated girls with intellectual disability and seizures. Clinical Genetics 82(6): 540-545.
Naeem, F., Taj, R., Khan, A. & Ayub, M (2012). Can watching traumatic events on TV cause PTSD symptoms? Evidence from Pakistan. Acta Psychiatrica Scandinavica 126(1): 79-80.
Ayub, M., Irfan, M., Naeem, F. & Blackwood, D. (2012). Major depression in a large family in Pakistan: No relationship to inbreeding, economic status or rural living. Journal of Pakistan Psychiatric Society 9(1): 37.
Khan, M. A., Rafiq, M. A., Noor, A., Hussain, S., Flores, J. V., Rupp, V., Vincent, A. K., Malli, R., Ali, G., Khan, F. S., Ishak; G. E., Doherty, D., Weksberg, R., Ayub, M., Windpassinger, C., Ibrahim, S., Frye, M., Ansar, M. & Vincent, J. B. (2012). Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability. The American Journal of Human Genetics 90(5): 856-863.
Naeem, F., Ayub, M., Kingdon, D. & Gobbi, M. (2012). Patient's experience of depression in Pakistan: A qualitative study. Qualitative Health Research 22: 1083-1093.
Ayub, M., Poongan, I., Masood, K., Gul, H., Ali, M., Farrukh, A., Shaheen, A., Chaudhry, H. R. & Naeem, F. (2012). Psychological Morbidity in Children 18 months after Kashmir Earthquake of 2005. Child Psychiatry & Human Development 43(3): 323-336.
Naeem, F., Ayub, M., Kingdon, D. & Gobbi, M. (2012). Views of Depressed Patients in Pakistan Concerning their Illness, its Causes and Treatment. Qualitative Health Research 22(8): 1083-1093.
Rafiq, M. A., Kuss, A. W., Puettmann, A. L., Noor, A., Ramiah, A., Ali, G., Hu, H., Kerio, N. A., Xiang, Y., Garshasbi, M., Khan, M. A., Ishak, G. E., Weksberg, R., Ullman, R., Tzschach, A., Kahrizi, K., Mahmood, K., Naeem, F., Ayub, M., Moremen, K. W., Vincent, J. B., Ropers, H. H., Ansar, M. & Najmabadi, H. (2011). Mutations in the Alpha 1,2-Mannosidase Gene, MAN1B1, Cause Autosomal-Recessive Intellectual Disability. American Journal of Human Genetics 89(1): 176-182.
Naeem, F., Ayub, M., Masood, K., Gul, H., Khalid, M., Farrukh, A., Shaheen, A., Waheed, W. & Chaudhry, H. R. (2011). Prevalence and Psychosocial risk factors of PTSD: 18 months after Kashmir Earthquake in Pakistan. Journal of Affective Disorders 130(1-2): 268-274.
Naeem, F., Saeed, A., Zaidi, Q., Kingdon, D. & Ayub, M. (2011). Urdu translation of the ICD-10 chapter V (F), Research Diagnostic Criteria (RDC): Process and principles of translation. Transcultural Psychiatry 48(4): 484-495.
Naeem, F., Waheed, W., Gobbi, M., Ayub, M. & Kingdon, D. (2010). Preliminary Evaluation of Culturally Sensitive CBT for Depression in Pakistan: Findings from Developing Culturally-Sensitive CBT Project (DCCP). Behavioural and Cognitive Psychotherapy 39(2): 165-173.
Naeem, F., Gobbi, M., Ayub, M. & Kingdon, D. (2010). Psychologists Experience of Cognitive Behaviour Therapy in a Developing Country: a qualitative study from Pakistan. International Journal of Mental Health Systems 4(2).
Kaufman, L., Ayub, M. & Vincent, J. B. (2010). The genetic basis of non-syndromic intellectual disability: a review. Journal of Neurodevelopmental Disorders 2(4): 182-209.
Naeem, F., Ayub, M., Gobbi, M. & Kingdon, D. (2009). Development of Southampton Adaptation Framework for CBT (SAF-CBT): A Framework for Adaptation of CBT in Non-Western Culture. Journal of Pakistan Psychiatric Society 6(2): 79-84.
Mir, A., Kaufman, L., Noor, A., Motazacker, M. M., Jamil, T., Azam, M., Kahrizi, K., Rafiq, M. A., Weksberg, R., Nasr, T., Naeem, F., Tzschach, A., Kuss, A. W., Ishak, G. E., Doherty, D., Ropers, H. H., Barkovich, A. J., Najmabadi, H., Ayub, M. & Vincent, J. B. (2009). Identification of Mutations in TRAPPC9, which Encodes the NIK- and IKK-β-Binding Protein, in Nonsyndromic Autosomal-Recessive Mental Retardation. The American Journal of Human Genetics 85(6): 909-915.
Jacoby, M., Cox, J. J., Gayral, S., Hampshire, D., Ayub, M., Blockmans, M., Pernot, E., Kisseleva, M. V., Compère, P., Schiffmann, S. N., Gergely, F., Riley, D., Pérez-Morga, D., Woods, C. G. & Schurmans, S. (2009). INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse. Nature Genetics 41(9): 1027-1031.
Noor, A., Windpassinger, C., Vitcu, I., Orlic, I., Rafiq, M. A., Khalid, M., Malik, M. N., Ayub, M., Alman, B. & Vincent, J. B. (2009). Oligodontia is Caused by Mutation in LTBP3, the Gene Encoding Latent TGF-β Binding Protein 3. The American Journal of Human Genetics 84(4): 519-523.
Ayub, M., Irfan, M., Nasr, T., Lutufullah, M., Kingdon, D. & Naeem, F. (2009). Psychiatric morbidity and domestic violence: A survey of married women in Lahore. Social Psychiatry and Psychiatric Epidemiology 44(11): 953-960.
Naeem, F., Gobbi, M., Ayub, M. & Kingdon, D. (2009). University students' views about compatibility of cognitive behaviour therapy (CBT) with their personal, social and religious values (a study from Pakistan). Mental Health, Religion & Culture 12(8): 847-855.
Naeem, F., Irfan, M., Zaidi, Q. A., Kingdon, D. & Ayub, M. (2008). Angry wives, abusive husbands: relationship between domestic violence and psychosocial variables. Women's Health Issues 18(6): 453-462.
Noor, A., Windpassinger, C., Patel, M., Stachowiak, B., Mikhailov, A., Azam, M., Irfan, M., Paterson, A. D., Lutufullah, M., Doherty, D., Vincent, J. B. & Ayub, M. (2008). CC2D2A, Encoding a Coiled-Coil and C2 Domain Protein, Causes Autosomal-Recessive Mental Retardation with Retinitis Pigmentosa (Addendum). The American Journal of Human Genetics 83(5): 656.
Noor, A., Windpassinger, C., Patel, M., Stachowiak, B., Mikhailov, A., Siddiqui, Z. K., Naeem, F., Azam, M., Irfan, M., Paterson, A. D., Lutufullah, M., Vincent, J. B. & Ayub, M. (2008). CC2D2A, Encoding a Coiled-Coil and C2 Domain Protein, causes Autosomal-Recessive Mental Retardation with Retinitis Pigmentosa. The American Journal of Human Genetics 82(4): 1011-1018.
Ayub, M. & Blackwood, D. H. R. (2008). Gene Discovery in Schizophrenia and Bipolar Disorder (Guest Editorial). Journal of Pakistan Psychiatric Society 5(2): 55.
Knight, H. M., Maclean, A., Irfan, M., Naeem, F., Cass, S., Pickard, B. S., Muir, W. J., Blackwood, D. H. R. & Ayub, M. (2008). Homozygosity mapping in a family presenting with schizophrenia, epilepsy and hearing impairment. European Journal of Human Genetics 16(6): 750-758.
Ayub, M., Irfan, M., Maclean, A., Naeem, F., MacGregor, S., Visscher, P. M., Muir, W. J. & Blackwood, D. H. R. (2008). Linkage Analysis in a Large Family from Pakistan with Depression and a High Incidence of Consanguineous Marriages. Human Heredity 66(3): 190-198.
Naeem, F., Ayub, M., Irfan, M., Javed, Z. & Kingdon, D. (2007). A comparison of the knowledge of psychiatric problems among medical students, doctors and university teachers and students in Lahore, Pakistan. Journal of Pakistan Psychiatric Society 4(1): 25-28.
Naeem, F., Ayub, M., Kingdon, D., Mujtaba, M., Zaidi, Q. A., Bhatti, F. & Chaudhry, H. R. (2007). A Survey of Knowledge and Attitude of the General Public towards Epilepsy in Lahore, Pakistan. Journal of Pakistan Psychiatric Society 4(2): 96-99.
Javed, Z., Naeem, F., Kingdon, D., Irfan, M., Izhar, N. & Ayub, M. (2006). Attitude of the University Students and Teachers towards Mentally Ill, in Lahore, Pakistan. Journal of Ayub Medical College Abbottabad, Pakistan 18(3): 55-58.
Hampshire, D. J., Ayub, M., Springell, K., Roberts, E., Jafri, H., Rashid, Y., Bond, J., Riley, J. H. & Woods, C. G. (2006). MORM syndrome (mental retardation, truncal obesity, retinal dystrophy, and micropenis), a new autosomal recessive disorder, links to 9q34. European Journal of Human Genetics 14(5): 543-548.
Naeem, F., Ayub, M., Javed, Z., Irfan, M., Haral, F. & Kingdon, D. (2006). Stigma and Psychiatric Illness: A survey of attitude of medical students and doctors in Lahore, Pakistan. Journal of Ayub Medical College Abbottabad, Pakistan 18(3): 46-49.
Khalil, M., Ayub, M., Naeem, F., Irfan, M., Rehman, S. U., Bacha, S. U., Alam, M. B. & Ashraf, N. (2005). APPNA SEHAT: A description of the development of a health education programme in rural Pakistan. International Journal of Health Promotion and Education 43(4): 137-144.
Mumford, D. B., Ayub, M., Karim, R., Izhar, N., Asif, A. & Bavington, J. T. (2005). Development and Validation of a Questionnaire for Anxiety and Depression in Pakistan. Journal of Affective Disorders 88(2): 175-182.
Naeem, F., Mufti, K. A., Ayub, M., Haroon, A., Saifi, F., Qureshi, S. M., Ihsan, A., Chaudry, H. R., Dagarwal, S. U. R. & Kingdon, D. (2005). Psychiatric morbidity among Afghan refugees in Peshawar, Pakistan. Journal of Ayub Medical College Abbottabad, Pakistan 17(2): 23-25.
Mufti, K. A., Naeem, F., Ayub, M., Saifi, F., Haroon, A., Dagarwal, S. U. R. & Kingdon, D. (2005). Psychiatric problems in an Afghan village. Journal of Ayub Medical College Abbottabad, Pakistan 17(3): 19-20.
Naeem, F., Ayub, M., Izhar, N., Javed, Z., Irfan, M., Haral, F. & Kingdon, D. (2005). Stigma and knowledge of depression: a survey comparing medical and non-medical students and staff in Lahore, Pakistan. Pakistan Journal of Medical Science 21(2): 155-158.
Naeem, F. & Ayub, M. (2004). Psychiatric training in Pakistan. Medical Education Online 9: 19.
Khan, N. S., Akhtar, M. S., Ayub, M., Alam, S. & Laghari, N. U. (2003). Translation and validation of quality of life scale, the brief version. Journal of College of Physicians and Surgeons Pakistan 13(2): 98-100.
Rana, N. H. & Ayub, M. (2002). Non-compliance to medication in psychiatric patients. Pakistan Journal of Medical Sciences 18(1): 52-54.
Ayub, M. & Nazir, Z. (2001). The stress of caring among parents of children with psychiatric disorders and mental retardation. Medical Forum Monthly 12(3): 5-7.
Ayub, M. & Tayyab, G. U. N. (1999). Acute Intermittent Porphyria: Presenting with Psychiatric Symptoms. Pakistan Journal of Neurology 5(1): 6-7.
Ayub, M., Lang, F. H. & Johnstone, E. C. (1999). Brain Disease and Psychopathology Difficulties in Diagnosis and Patient Management. ANNALS of King Edward Medical College, Lahore, Pakistan 5(2): 162-164.
Karim, R., Ayub, M., Izhar, N., Asif, A., Aziz, R. & Haq, I. (1999). What do the Doctors in Lahore think about Psychiatry?. ANNALS of King Edward Medical College, Lahore, Pakistan 5(2): 170-173.
Mumford, D. B., Tareen, I. A. K., Bajwa, M. A. Z., Bhatti, M. R., Pervaiz, T. & Ayub, M. (1991). An investigation of 'Functional' Somatic Symptoms Among Patients Attending Hospital Medical Clinics in Pakistan - I. Characteristics of "non-organic" Patients. Journal of Psychosomatic Research 35(2-3): 245-255.
Mumford, D. B., Tareen, I. A. K., Bhatti, M. R., Bajwa, M. A. Z., Ayub, M. & Pervaiz, T. (1991). An investigation of 'Functional' Somatic Symptoms Among Patients Attending Hospital Medical Clinics in Pakistan- II. Using Somatic Symptoms to Identify Patients with Psychiatric Disorders. Journal of Psychosomatic Research 35(2-3): 257-264.
Ayub, M. (1991). Child Mental Health and Media. The Pakistan Journal of Child Mental Health 1(2): 82-84.
Bashir, A., Tareen, I. A. K. & Ayub, M. (1991). Etiology, Psychological Morbidity and Associated Impairments in Severe Mental Retardation. The Pakistan Journal of Child Mental Health 1(2): 1-13.

Journal papers: online

Badner, J. A., Koller, D., Foroud, T., Edenberg, H., Nurnberger, J. I., Zandi, P. P., Willour, V. L., McMahon, F. J., Potash, J. B., Hamshere, M., Grozeva, D., Green, E., Kirov, G., Jones, I., Jones, L., Craddock, N., Morris, D., Segurado, R., Gill, M., Sadovnick, D., Remick, R., Keck, P., Kelsoe, J., Ayub, M., MacLean, A., Blackwood, D., Liu, C.-Y., Gershon, E. S., McMahon, W., Lyon, G. J., Robinson, R., Ross, J. & Byerley, W. (2012). Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms. Molecular Psychiatry 17(8): 818-826.

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