• EPSRC Programme Grant
Dr Sanderson is a co-investigator on a large collaborative grant awarded by the EPSRC. The CAPiTALS programme aims to engineer the assembly of soft matter, such as lipid membranes, into well defined architectures that exhibit compositional asymmetry. For membranes this includes the lateral segregation and bilayer asymmetry in response to factors such as membrane curvature. This molecular membrane engineering approach will ultimately lead to new biologically-inspired devices and "smart" soft materials. To learn more, click here.
• Review of Membrane Kinetics
Recent developments in the understanding of molecular diffusion phenomena in membranes are reviewed. Both model bilayers and biological membranes are considered in respect of lateral diffusion, rotational diffusion and transverse diffusion (flip-flop). For model systems, particular attention is paid to recent data obtained using surface-specific techniques such as sum frequency generation vibrational spectroscopy on supported lipid bilayers, and fluorescence correlation spectroscopy on giant unilamellar vesicles, both of which have yielded new insights into the intrinsic rates of diffusion and the energetic barriers to processes such as lipid flip-flop. Advances in single-molecule and many-molecule fluorescence methodologies have enabled the observation of processes such as anomalous diffusion for some membrane species in biological membranes. These are discussed in terms of new models for the role of membrane interactions with the cytoskeleton, the effects of molecular crowding in membranes, and the formation of lipid rafts. The diffusion of peptides, proteins and lipids is considered, particularly in relation to the means by which antimicrobial peptide activity may be rationalized in terms of membrane poration and lipid flip-flop. To access the full text of the article, click here.
The Sanderson group is located in the Department of Chemistry and the Biophysical Sciences Institute (BSI) at Durham University. To read more about the BSI, click here.