Regulation at simple and complex bacterial promoters
Dr. Stephen Busby University of Birmingham Seminar sponsored by SCION PUBLISHING
The expression of most bacterial genes is principally regulated at the level of the initiation of transcription. The contributions of promoter elements, sigma factors and transcription factors to this regulation at simple promoters are well understood. It is now appreciated that most promoters are directly regulated by several transcription factors. I will present recent work that elucidates some of the mechanisms by which the contributions of different factors are integrated at complex promoters. In some cases, nucleoid-associated proteins play an essential role in this integration. Recent advances that reveal the distribution of transcription factors across bacterial genomes will be discussed. Key references: Browning, D & Busby, S (2004) The regulation of bacterial transcription initiation. Nature Reviews Microbiology 2 57-65 Wade, JT, Struhl, K, Busby, SJW & Grainger, DC (2007) Genomic analysis of protein-DNA interactions in bacteria: insights into transcription and chromosome organization. Molecular Microbiology 65 21-26 Grainger, D, Goldberg, M, Lee, D & Busby, S (2008) Selective repression by Fis and H-NS at the Escherichia coli dps promoter. Molecular Microbiology 68 1366-1377 Web page: http://www.biosciences.bham.ac.uk/About/staff_profiles_Contact.htm?ID=4
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