Temperature Perception and Primordia Fate Determination
Dr. Philip Wigge John Innes Centre Sponsored by QIAGEN
We study how plants sense changes in environmental conditions, particularly ambient temperature, and how these signals are integrated into development. Using Arabidopsis, we have carried out genetic screens to identify mutants in key regulatory components of the temperature sensing pathways. Interestingly, many of these lines have altered growth, indicating their importance in integrating temperature sensing signals into plant development. A second area of interest for the lab is how primordia fate is determined and factors that provide spatial information. Primordia fate specification and the relative contributions of vegetative versus floral signals have a profound effect, not just on flowering time, but also on the entire architecture and growth habit of the plant. The integration of these signals to control growth and development is still poorly understood. Arabidopsis is an ideal multicellular system for studying transcriptional switches and regulatory networks at the transcription factor and epigenetic level, and in collaboration with Richard Morris (JIC Dept of Computational and Systems Biology) we are characterising ways to represent and model different types of biological switch, particularly continuously variable switches. Web page: http://www.jic.ac.uk/profile/philip-wigge.asp Publications: Kumar, V and Wigge, PA. (2007) Red sky in the morning, shepherd's warning (News & Views) Nat Genet. 39: 1309-10. Jaeger, KE and Wigge, PA. (2007) FT protein acts as a long-range signal in Arabidopsis Current Biology 17: 1050-4 Wigge PA, Kim MC, Jaeger KE, Busch W, Schmid M, Lohmann JU, Weigel D. (2005) Integration of spatial and temporal information during floral induction in Arabidopsis. Science 309: 1056- 1059 (83 citations, ISI Web of Knowledge) Jaeger, KE, Graf, A and Wigge PA (2006) The control of flowering in time and space. J Exp Bot. Sep 27 Samach A and Wigge PA (2005) Ambient temperature perception in plants. Curr Opin Plant Biol. 8: 483-6. Wigge PA, Jensen ON, Holmes S, Soues S, Mann M, Kilmartin JV. (1998) Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. J Cell Biol. 141: 967-77. (194 citations, ISI Web of Knowledge) Wigge PA, Kilmartin JV. (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. (138 citations, ISI Web of Knowledge) J Cell Biol. 152: 349-60. Wigge PA, Weigel D. (2001) Arabidopsis genome: life without notch. Curr Biol.11:R112-4. Wu X, Weigel D, Wigge PA. (2002) Signaling in plants by intercellular RNA and protein movement. Genes Dev. 16:151-8
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