Staff Profile

Prof AR Slabas

Contact Prof AR Slabas (email at a.r.slabas@durham.ac.uk)

Toni Slabas obtained his BSc, in Chemistry and Microbiology , from Queen Mary College, University of London [1971] and his D.Phil from Oxford [1974]. He conducted postdoctoral research with Professor David Walker in Sheffield on the dark acts of Photosynthesis and with Professor MCW Evans at UCL-London on the primary acts of photosynthesis. He spent 13 years at Unilever Research[Sharnbrook Bedford] eventually becoming Section manager of Cell Sciences. During that time the Plant Molecular Biology group and the Protein Chemistry section were founded. He has a strong interest in protein chemistry and lipid metabolism. His group established proteomics in Durham as a state of the art facility. His main interests are in the application of proteomics to solving biological problems, acclimation of cyanobacteria to heat, macromolecular architecture of the lipid biosynthetic machinery and triacylglycerol assembly and the mechanism by which extracellular ATP suppresses a default death pathway in plants.

In 2000 he co-founded, with Professor Keith Lindsey, a spin out company Creative Gene Technology whose main objective is to find innovative ways of increasing plant yield and productivity.

He has served on various BBSRC committees and visiting groups, two Government Foresight Committees and the Governing Body of The Scottish Crops Research Institute. He is currently a member of the BBSRC Sustainable Agriculture Panel, the DEFRA LINK programme advisory panel on renewable raw materials and an editor of Proteomics.

Related Links

• Proteomic facility

Research Groups

• Durham Centre for Crop Improvement Technology

Supervises

• Dr JTM Kroon
• Dr John Rowland
• Dr A Brown
• Miss Stephanie Johnson

Research Interests

• Regulation of lipids metabolism
• Proteomics
• Cyanobacteria and stress responses
• Extracellular ATP in Plants and its role in suppression of cell death

Publications

Journal papers: academic

• Brown, AP, Kroon, JT, Swarbreck, D, Febrer, M,, Larson, TR, Graham, IA, Caccamo, M & Slabas, AR (2012). Tissue-specific whole transcriptome sequencing in castor, directed at understanding triacylglycerol lipid biosynthetic pathways. PLoS ONE 7(2): e30100
• Eastmond, PJ, Quettier, AL, Kroon, JT , Craddock, C, Adams, N & Slabas, AR (2011). A phosphatidate phosphatase double mutant provides a new insight into plant membrane lipid homeostasis. Plant Signaling & Behavior 6(4): 526-527.
• Brown, AP, Kroon, JTM , Topping, JF, Robson, JL, Simon, WJ & Slabas, AR (2011). Components of Complex Lipid Biosynthetic Pathways in Developing Castor (Ricinus communis) Seeds Identified by MudPIT Analysis of Enriched Endoplasmic Reticulum. Journal of Proteome Research 10(8): 3565-3577.
• Chivasa, S & Slabas, AR (2011). Plant extracellular ATP signalling: new insight from proteomics. Molecular BioSystems
• Chivasa, S, Tome, DFA, Hamilton, JM & Slabas, AR (2011). Proteomic Analysis of Extracellular ATP-Regulated Proteins Identifies ATP Synthase beta-Subunit as a Novel Plant Cell Death Regulator. Molecular & Cellular Proteomics 10(3): N/A.
• Rowland, John G., Simon, William J., Prakash, Jogadhenu S.S. & Slabas, Antoni R. (2011). Proteomics Reveals a Role for the RNA Helicase crhR in the Modulation of Multiple Metabolic Pathways during Cold Acclimation of Synechocystis sp PCC6803. Journal of Proteome Research 10(8): 3674-3689.
• Rowland JG, , Simon JW, , Nishiyama Y, & Slabas AR. (2010). Differential proteomic analysis using iTRAQ reveals changes in thylakoids associated with Photosystem II-acquired thermotolerance in Synechocystis sp. PCC 6803. Proteomics 10(10): 1917-1929.
• Rowland, JG, Pang, X, Suzuki, I, Murata, N, Simon, JW & Slabas, AR (2010). Identification of Components Associated with Thermal Acclimation of Photosystem II in Synechocystis sp PCC6803. Plos One 5(5): e10511.
• Eastmond, PJ, Quettier, AL, Kroon, JTM, Craddock, C, Adams, N & Slabas, AR (2010). Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis. Plant Cell 22(8): 2796-2811.
• Eastmond, Peter J., Quettier, Anne-Laure, Kroon, Johan T.M., Craddock, Christian, Adams, Nicolette & Slabas, Antoni R. (2010). PHOSPHATIDIC ACID PHOSPHOHYDROLASE1 and 2 Regulate Phospholipid Synthesis at the Endoplasmic Reticulum in Arabidopsis. Plant Cell 22(8): 2796-2811.
• Chivasa S, , Tome DF, , Hamilton JM, & Slabas AR. (2010). Proteomic analysis of extracellular ATP-regulated proteins identifies ATP synthase {beta}-subunit as a novel plant cell death regulator. Molecular Cell Proteomics
• Nanjo, Y, Mizusawa, N, Wada, H, Slabas, AR, Hayashi, H & Nishiyama, Y (2010). Synthesis of fatty acids de novo is required for photosynthetic acclimation of Synechocystis sp PCC 6803 to high temperature. Biochimica Et Biophysica Acta-bioenergetics 1797(8): 1483-1490.
• Chivasa, S, Simon, JW, Murphy, AM, Lindsey, K, Carr, JP & Slabas, AR (2010). The effects of extracellular adenosine 5 '-triphosphate on the tobacco proteome. Proteomics 10(2): 235-244.
• Chivasa, S., Murphy, A., Hamilton, J., Lindsey, K., Carr, J. & Slabas, A.R. (2009). Extracellular ATP is a regulator of pathogen defence in plants. The Plant Journal 60(3): 436-448.
• Demidchik, V, Shang, ZL, Shin, R, Thompson, E, Rubio, L, Laohavisit, A, Mortimer, JC, Chivasa, S, Slabas, AR, Glover, BJ, Schachtman, DP, Shabala, SN & Davies, JM (2009). Plant extracellular ATP signalling by plasma membrane NADPH oxidase and Ca2+ channels. Plant Journal 58(6): 903-913.
• Brown, AP, Affleck, V, Kroon, JTM & Slabas, AR (2009). Proof of function of a putative 3-hydroxyacyl-acyl carrier protein dehydratase from higher plants by mass spectrometry of product formation. Febs Letters 583(2): 363-368.
• Simon, W. J., Maltman, D. J. & Slabas, A. R. (2008). Isolation and fractionation of the endoplasmic reticulum from castor bean (Ricinus communis) endosperm for proteomic analyses. 425: 203-215.
• O'Hara, Paul., Slabas, Antoni R. & Fawcett, Tony. (2007). Antisense expression of 3-oxoacyl-ACP reductase affects whole plant productivity and causes collateral changes in activity of fatty acid synthase components. Plant and Cell Physiology 48(5): 736-744.
• Maltman, DJ, Gadd, SM, Simon, JW & Slabas, AR (2007). Differential proteomic analysis of the endoplasmic reticulum from developing and germinating seeds of castor (Ricinus communis) identifies seed protein precursors as significant components of the endoplasmic reticulum. Proteomics 7(9): 1513-1528.
• Rowland, JG, Robson, JL, Simon, JW, Leung HY & Slabas, AR (2007). Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics 7(1): 47-63.
• Roujeinikova, A, Simon, JW, Gilroy, J, Rice, DW, Rafferty, JB & Slabas, AR (2007). Structural studies of fatty acyl-(acyl carrier protein) thioestersreveal a hydrophobic binding cavity that can expand to fit longersubstrates. Journal Of Molecular Biology 365(1): 135-145.
• Kroon, JTM, Wei, WX, Simon, JW & Slabas, AR (2006). Identification and functional expression of a type 2 acyl-CoAdiacylglycerol acyltransferase (DGAT2) in developing castor bean seedswhich has high homology to the major triglyceride biosynthetic enzymeof fungi and animals. Phytochemistry 67(23): 2541-2549.
• Chivasa, S., Hamilton, J.M. , Pringle, R.S. Ndimba, B.K. Simon, J.W., Lindsey, K. & Slabas, A.R. (2006). Proteomic analysis of differentially expressed proteins in fungal elicitor-treated Arabidopsis cell cultures. Journal of Experimental Botany 57: 1553-1562.
• Slabas, AR, Suzuki, I, Murata, N, Simon, JW & Hall, JJ (2006). Proteomic analysis of the heat shock response in Synechocystis PCC6803 and a thermally tolerant knockout strain lacking the histidine kinase34 gene. Proteomics 6(3): 845-864.
• Brown, AP, Affleck, V, Fawcett, T & Slabas, AR (2006). Tandem affinity purification tagging of fatty acid biosynthetic enzymesin Synechocystis sp PCC6803 and Arabidopsis thaliana. Journal Of Experimental Botany 57(7): 1563-1571.
• Suzuki, I, Simon, JW & Slabas, AR (2006). The heat shock response of Synechocystis sp PCC 6803 analysed bytranscriptomics and proteomics. Journal Of Experimental Botany 57(7): 1573-1578.
• Cheng, Q, Sanglard, D, Vanhanen, S, Liu, HT, Bombelli, P, Smith, A & Slabas, AR (2005). Candida yeast long chain fatty alcohol oxidase is a c-type haemoproteinand plays an important role in long chain fatty acid metabolism. Biochimica Et Biophysica Acta-molecular And Cell Biology Of Lipids 1735(3): 192-203.
• Chivasa, S, Ndimba, BK, Simon, JW, Lindsey, K & Slabas, AR (2005). Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability. Plant Cell 17(11): 3019-3034.
• Ndimba, BK, Chivasa, S, Simon, JW & Slabas, AR (2005). Identification of Arabidopsis salt and osmotic stress responsive proteins using two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics 5(16): 4185-4196.
• Chivasa, S, Simon, WJ, Yu, XL, Yalpani, N & Slabas, AR (2005). Pathogen elicitor-induced changes in the maize extracellular matrix proteome. Proteomics 5(18): 4894-4904.
• Suzuki, I, Kanesaki, Y, Hayashi, H, Hall, JJ, Simon, JW, Slabas, AR & Murata, N (2005). The histidine kinase Hik34 is involved in thermotolerance by regulatingthe expression of heat shock genes in synechocystis. Plant Physiology 138(3): 1409-1421.
• Cheng, Q, Liu, HT, Bombelli, P, Smith, A & Slabas, AR (2004). Functional identification of AtFao3, a membrane bound long chainalcohol oxidase in Arabidopsis thaliana. Febs Letters 574(1-3): 62-68.
• Slabas, AR, Ndimba, B, Simon, JW & Chivasa, S (2004). Proteomic analysis of the Arabidopsis cell wall reveals unexpected proteins with new cellular locations. Biochemical Society Transactions 32: 524-528.
• Bolwell, GP, Slabas, AR & Whitelegge, JP (2004). Proteomics: empowering systems biology in plants. Phytochemistry 65(12): 1665-1669.
• Rowland, JG, Simon, JW, Slabas, AR, Robson, CN & Leung, HY (2004). Quantitative proteomic analysis of androgen & anti-androgen responsesin the LNCaP prostate cancer cell line. British Journal Of Cancer 91: S38-S38.
• Hamilton, JMU, Simpson, DJ, Hyman, SC, Ndimba, BK & Slabas, AR (2003). Ara12 subtilisin-like protease from Arabidopsis thaliana: purification,substrate specificity and tissue localization. Biochemical Journal 370: 57-67.
• Ndimba, BK, Chivasa, S, Hamilton, JM, Simon, WJ & Slabas, AR (2003). Proteomic analysis of changes in the extracellular matrix ofArabidopsis cell suspension cultures induced by fungal elicitors. Proteomics 3(6): 1047-1059.
• Roujeinikova, A, Baldock, C, Simon, JW, Gilroy, J, Baker, PJ, Stuitje, AR, Rice, DW, Rafferty, JB & Slabas, AR (2002). Crystallization and preliminary X-ray crystallographic studies onacyl-(acyl carrier protein) from Escherichia coli. Acta Crystallographica Section D-biological Crystallography 58: 330-332.
• O'Hara, P, Slabas, AR & Fawcett, T (2002). Fatty acid and lipid biosynthetic genes are expressed at constant molarratios but different absolute levels during embryogenesis. Plant Physiology 129(1): 310-320.
• Slabas, AR, White, A, O'Hara, P & Fawcett, T (2002). Investigations into the regulation of lipid biosynthesis in Brassica napus using antisense down-regulation. Biochemical Society Transactions 30: 1056-1059.
• Hayman, MW, Fawcett, T & Slabas, AR (2002). Kinetic mechanism and order of substrate binding forsn-glycerol-3-phosphate acyltransferase from squash (Cucurbita moschata). Febs Letters 514(2-3): 281-284.
• Brown, AP, Carnaby, S, Brough, C, Brazier, M & Slabas, AR (2002). Limnanthes douglasii lysophosphatidic acid acyltransferases:immunological quantification, acyl selectivity and functionalreplacement of the Escherichia coli plsC gene. Biochemical Journal 364: 795-805.
• Chivasa, S, Ndimba, BK, Simon, JW, Robertson, D, Yu, XL, Yu, XL, Knox, JP, Bolwell, P & Slabas, AR (2002). Proteomic analysis of the Arabidopsis thaliana cell wall. Electrophoresis 23(11): 1754-1765.
• Maltman, DJ, Simon, WJ, Wheeler, CH, Dunn, MJ, Wait, R & Slabas, AR (2002). Proteomic analysis of the endoplasmic reticulum from developing andgerminating seed of castor (Ricinus communis). Electrophoresis 23(4): 626-639.
• Slabas, AR, Kroon, JTM, Scheirer, TP, Gilroy, JS, Hayman, M, Rice, DW, Turnbull, AP, Rafferty, JB, Fawcett, T & Simon, WJ (2002). Squash glycerol-3-phosphate (1)-acyltransferase - Alteration of substrate selectivity and identification of arginine and lysineresidues important in catalytic activity. Journal Of Biological Chemistry 277(46): 43918-43923.
• Brown, AP, Slabas, AR & Denton, H (2002). Substrate selectivity of plant and microbial lysophosphatidic acidacyltransferases. Phytochemistry 61(5): 493-501.
• Roujeinikova, A, Baldock, C, Simon, WJ, Gilroy, J, Baker, PJ, Stuitje, AR, Rice, DW, Slabas, AR & Rafferty, JB (2002). X-ray crystallographic studies on butyryl-ACP reveal flexibility of thestructure around a putative acyl chain binding site. Structure 10(6): 825-835.
• Levy, CW, Baldock, C, Wallace, AJ, Sedelnikova, S, Viner, RC, Clough, JM, Stuitje, AR, Slabas, AR, Rice, DW & Rafferty, JB (2001). A study of the structure-activity relationship for diazaborineinhibition of Escherichia coli enoyl-ACP reductase. Journal Of Molecular Biology 309(1): 171-180.
• Slabas, AR, Hanley, Z, Schierer, T, Rice, D, Turnbull, A, Rafferty, J, Simon, JW & Brown, AP (2001). Acyltransferases and their role in the biosynthesis of lipids opportunities for new oils. Journal Of Plant Physiology 158(4): 505-513.
• Turnbull, AP, Rafferty, JB, Sedelnikova, SE, Slabas, AR, Schierer, TP, Kroon, JTM, Simon, JW, Fawcett, T, Nishida, I, Murata, N & Rice, DW (2001). Analysis of the structure, substrate specificity, and mechanism ofsquash glycerol-3-phosphate (1)-acyltransferase. Structure 9(5): 347-353.
• Slabas, AR, Simon, JW & Brown, AP (2001). Biosynthesis and regulation of fatty acids and triglycerides in oilseed rape. Current status and future trends. European Journal Of Lipid Science And Technology 103(7): 455-466.
• Turnbull, AP, Rafferty, JB, Sedelnikova, SE, Slabas, AR, Schierer, TP, Kroon, JTM, Nishida, J, Murata, N, Simon, JW & Rice, DW (2001). Crystallization and preliminary X-ray analysis of theglycerol-3-phosphate 1-acyltransferase from squash (Cucurbita moschata). Acta Crystallographica Section D-biological Crystallography 57: 451-453.
• O'Hara, P, Slabas, AR & Fawcett, T (2001). Fatty acid synthesis in developing leaves of Brassica napus in relationto leaf growth and changes is activity of 3-oxoacyl-ACP reductase. Febs Letters 488(1-2): 18-22.
• Blee, KA, Wheatley, ER, Bonham, VA, Mitchell, GP, Robertson, D, Slabas, AR, Burrell, MM, Wojtaszek, P & Bolwell, GP (2001). Proteomic analysis reveals a novel set of cell wall proteins in a transformed tobacco cell culture that synthesises secondary walls asdetermined by biochemical and morphological parameters. Planta 212(3): 404-415.
• Vanhanen, S, West, M, Kroon, JTM, Lindner, N, Casey, J, Cheng, Q, Elborough, KM & Slabas, AR (2000). A consensus sequence for long-chain fatty-acid alcohol oxidases fromCandida identifies a family of genes involved in lipid omega-oxidationin yeast with homologues in plants and bacteria. Journal Of Biological Chemistry 275(6): 4445-4452.
• Fisher, M, Sedelnikova, SE, Martindale, W, Thomas, NC, Simon, JW, Slabas, AR & Rafferty, JB (2000). Crystallization of the NADP-dependent beta-keto acyl-carrier proteinreductase from Brassica napus. Acta Crystallographica Section D-biological Crystallography 56: 86-88.
• Sellwood, C, Slabas, AR & Rawsthorne, S (2000). Effects of manipulating expression of acetyl-CoA carboxylase I inBrassica napus L. embryos. Biochemical Society Transactions 28: 598-600.
• O'Hara, P, Slabas, AR & Fawcett, T (2000). Expression of fatty acid and lipid biosynthetic genes. Biochemical Society Transactions 28: 617-619.
• Fawcett, T, Copse, CL, Simon, JW & Slabas, AR (2000). Kinetic mechanism of NADH-enoyl-ACP reductase from Brassica napus. Febs Letters 484(2): 65-68.
• Wilmer, JA, Brown, AP, Forsyth, K, Carnaby, S, Barsby, T & Slabas, AR (2000). Limnanthes douglasii erucic acid-specific lysophospatidic acidacyltransferase activity in oilseed rape: an analysis of biochemical effects. Biochemical Society Transactions 28: 964-966.
• O'Hara, P, Slabas, AR & Fawcett, T (2000). Modulation of fatty acid biosynthesis by antisense beta-keto reductaseexpression. Biochemical Society Transactions 28: 613-615.
• Hayman, MW, Fawcett, T, Schierer, TF, Simon, JW, Kroon, JTM, Gilroy, JS, Rice, DW, Rafferty, J, Turnbull, AP, Sedelnikova, SE & Slabas, AR (2000). Mutagenesis of squash (Cucurbita moschata) glycerol-3-phosphateacyltransferase (GPAT) to produce an enzyme with altered substrateselectivity. Biochemical Society Transactions 28: 680-681.
• Slabas, AR, Simon, WR, Schierer, T, Kroon, JTM, Fawcett, T, Hayman, M, Gilroy, J, Nishida, I, Murata, N, Rafferty, J, Turnbull, A & Rice, D (2000). Plant glycerol-3-phosphate-1-acyltransferase (GPAT): structure selectivity studies. Biochemical Society Transactions 28: 677-679.
• Fisher, M, Kroon, JTM, Martindale, W, Stuitje, AR, Slabas, AR & Rafferty, JB (2000). The X-ray structure of Brassica napus beta-keto acyl carrier proteinreductase and its implications for substrate binding and catalysis. Structure With Folding & Design 8(4): 339-347.
• Roujeinikova, A, Levy, CW, Rowsell, S, Sedelnikova, S, Baker, PJ, Minshull, CA, Mistry, A, Colls, JG, Camble, R, Stuitje, AR, Slabas, AR, Rafferty, JB, Pauptit, RA, Viner, R & Rice, DW (1999). Crystallographic analysis of triclosan bound to enoyl reductase. Journal Of Molecular Biology 294(2): 527-535.
• Roujeinikova, A, Sedelnikova, S, de Boer, GJ, Stuitje, AR, Slabas, AR, Rafferty, JB & Rice, DW (1999). Inhibitor binding studies on enoyl reductase reveal conformationalchanges related to substrate recognition. Journal Of Biological Chemistry 274(43): 30811-30817.
• Levy, CW, Roujeinikova, A, Sedelnikova, S, Baker, PJ, Stuitje, AR, Slabas, AR, Rice, DW & Rafferty, JB (1999). Molecular basis of triclosan activity. Nature 398(6726): 383-384.
• de Boer, GJ, Pielage, GJA, Nijkamp, HJJ, Slabas, AR, Rafferty, JB, Baldock, C, Rice, DW & Stuitje, AR (1999). Molecular genetic analysis of enoyl-acyl carrier protein reductase inhibition by diazaborine. Molecular Microbiology 31(2): 443-450.
• Hanley, SZ, Pappin, DJC, Rahman, D, White, AJ, Elborough, KM & Slabas, AR (1999). Re-evaluation of the primary structure of Ralstonia eutropha phasin andimplications for polyhydroxyalkanoic acid granule binding. Febs Letters 447(1): 99-105.
• Simon, JW & Slabas, AR (1998). cDNA cloning of Brassica napus malonyl-CoA ACP transacylase (MCAT)(fab D) and complementation of an E-coli MCAT mutant. Febs Letters 435(2-3): 204-206.
• Rafferty, JB, Fisher, M, Langridge, SJ, Martindale, W, Thomas, NC, Simon, JW, Bithell, S, Slabas, AR & Rice, DW (1998). Crystallization of the NADP-dependent beta-keto acyl carrier protein reductase from Escherichia coli. Acta Crystallographica Section D-biological Crystallography 54: 427-429.
• Christie, WW, Gill, S, Nordback, J, Itabashi, Y, Sanda, S & Slabas, AR (1998). New procedures for rapid screening of leaf lipid components from Arabidopsis. Phytochemical Analysis 9(2): 53-57.
• Pearce, ML & Slabas, AR (1998). Phosphatidate phosphatase from avocado (Persea americana) -purification, substrate specificity and possible metabolic implicationsfor the Kennedy pathway and cell signalling in plants. Plant Journal 14(5): 555-564.
• de Boer, GJ, Kater, MM, Fawcett, T, Slabas, AR, Nijkamp, HJJ & Stuitje, AR (1998). The NADH-specific enoyl acyl carrier protein reductase:Characterization of a housekeeping gene involved in storage lipid synthesis in seeds of Arabidopsis and other plant species. Plant Physiology And Biochemistry 36(7): 473-486.
• Baldock, C, Rafferty, JB, Stuitje, AR, Slabas, AR & Rice, DW (1998). The X-ray structure of Escherichia coli enoyl reductase with boundNAD(+) at 2.1 angstrom resolution. Journal Of Molecular Biology 284(5): 1529-1546.
• Robertson, D, Mitchell, GP, Gilroy, JS, Gerrish, C, Bolwell, GP & Slabas, AR (1997). Differential extraction and protein sequencing reveals major differences in patterns of primary cell wall proteins from plants. Journal Of Biological Chemistry 272(25): 15841-15848.
• Ziegler, A, Macintosh, SM, Torrance, L, Simon, JW & Slabas, AR (1997). Recombinant antibody fragments that detect enoyl acyl carrier proteinreductase in Brassica napus. Lipids 32(8): 805-809.
• Baldock, C, Rafferty, JB, Sedelnikova, SE, Baker, PJ, Stuitje, AR, Slabas, AR, Hawkes, TR & Rice, DW (1996). A mechanism of drug action revealed by structural studies of enoyl reductase. Science 274(5295): 2107-2110.
• Elborough, KM, Winz, R, Deka, RK, Markham, JE, White, AJ, Rawsthorne, S & Slabas, AR (1996). Biotin carboxyl carrier protein and carboxyltransferase subunits of themulti-subunit farm of acetyl-CoA carboxylase from Brassica napus:Cloning and analysis of expression during oilseed rape embryogenesis. Biochemical Journal 315: 103-112.
• Nishida, I, Swinhoe, R, Slabas, AR & Murata, N (1996). Cloning of Brassica napus CTP:phosphocholine cytidylyltransferase cDNAsby complementation in a yeast cct mutant. Plant Molecular Biology 31(2): 205-211.
• Baldock, C, Rafferty, JB, Sedelnikova, SE, Bithell, S, Stuitje, AR, Slabas, AR & Rice, DW (1996). Crystallization of Escherichia coli enoyl reductase and its complexwith diazaborine. Acta Crystallographica Section D-biological Crystallography 52: 1181-1184.
• Allen, AK, Bolwell, GP, Brown, DS, Sidebottom, C & Slabas, AR (1996). Potato lectin: A three-domain glycoprotein with novelhydroxyproline-containing sequences and sequence similarities towheat-germ agglutinin. International Journal Of Biochemistry & Cell Biology 28(11): 1285-1291.
• Slabas, AR, Brown, AP, Rafferty, JB, Rice, DW, Baldock, C, Kroon, JTM, Simon, JW, Stuitje, AR & Brough, CL (1996). Soluble and membrane bound components of plant lipid synthesis. Comptes Rendus De L Academie Des Sciences Serie Iii-sciences De LaVie-life Sciences 319(11): 1043-1047.
• Brough, CL, Coventry, JM, Christie, WW, Kroon, JTM, Brown, AP, Barsby, TL & Slabas, AR (1996). Towards the genetic engineering of triacylglycerols of defined fatty acid composition: Major changes in erucic acid content at the sn-2position affected by the introduction of a1-acyl-sn-glycerol-3-phosphate acyltransferase from Limnanthesdouglasii into oi. Molecular Breeding 2(2): 133-142.
• VERWOERT, IIGS, BROWN, A, SLABAS, AR & STUITJE, AR (1995). A Zea mays GTP-binding protein of the ARF family complements an Escherichia coli mutant with a temperature-sensitive malonyl-coenzyme A:acyl carrier protein transacylase. Plant Molecular Biology 27(3): 629-633.
• RAFFERTY, JB, SIMON, JW, BALDOCK, C, ARTYMIUK, PJ, BAKER, PJ, STUITJE, AR, SLABAS, AR & RICE, DW (1995). Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase. Structure 3(9): 927-938.
• BROWN, AP, BROUGH, CL, KROON, JTM & SLABAS, AR (1995). Identification of a cDNA that encodes a 1-acyl-sn-glycerol-3-phosphate acyltransferase from Limnanthes douglasii. Plant Molecular Biology 29(2): 267-278.
• GULLIVER, BS & SLABAS, AR (1994). Acetoacyl-acyl carrier protein synthase from avocado: its purification, characterisation and clear resolution from acetyl CoA:ACP transacylase. Plant Molecular Biology 25(2): 179-191.
• SLABAS, AR, FORDHAMSKELTON, AP, FLETCHER, D, MARTINEZRIVAS, JM, SWINHOE, R, CROY, RRD & EVANS, IM (1994). Characterisation of cDNA and genomic clones encoding homologues of the 65 kDa regulatory subunit of protein phosphatase 2A in Arabidopsis thaliana. Plant Molecular Biology 26(4): 1125-1138.
• RAFFERTY, JB, SIMON, JW, STUITJE, AR, SLABAS, AR, FAWCETT, T & RICE, DW (1994). Crystallization of the NADH-specific enoyl acyl carrier protein reductase from Brassica napus. Journal Of Molecular Biology 237(2): 240-242.
• FAWCETT, T, SIMON, JW, SWINHOE, R, SHANKLIN, J, NISHIDA, I, CHRISTIE, WW & SLABAS, AR (1994). Expression of mRNA and steady-state levels of protein isoforms of enoyl-ACP reductase from Brassica napus. Plant Molecular Biology 26(1): 155-163.
• BROWN, AP, COLEMAN, J, TOMMEY, AM, WATSON, MD & SLABAS, AR (1994). Isolation and characterisation of a maize cDNA that complements a 1-acyl sn-glycerol-3-phosphate acyltransferase mutant of Escherichia coli and encodes a protein which has similarities to other acyltransferases. Plant Molecular Biology 26(1): 211-223.
• ELBOROUGH, KM, SWINHOE, R, WINZ, R, KROON, JTM, FARNSWORTH, L, FAWCETT, T, MARTINEZRIVAS, JM & SLABAS, AR (1994). Isolation of cDNAs from Brassica napus encoding the biotin-binding and transcarboxylase domains of acetyl-CoA carboxylase: assignment of the domain structure in a full-length Arabidopsis thaliana genomic clone. Biochemical Journal 301: 599-605.
• SLABAS, AR, BROWN, AP, SINDEN, BS, SWINHOE, R, SIMON, JW, ASHTON, AR, WHITFELD, PR & ELBOROUGH, KM (1994). Pivotal reactions in fatty acid synthesis. Progress In Lipid Research 33(1-2): 39-46.
• ELBOROUGH, KM, FARNSWORTH, L, WINZ, RA, SIMON, JW, SWINHOE, R & SLABAS, AR (1994). Regulation of primary storage products of oil seeds by manipulating the level of genes involved in lipid-metabolism on plant acetyl co-A carboxylase. Journal Of Cellular Biochemistry 113-113.
• ELBOROUGH, KM, SIMON, JW, SWINHOE, R, ASHTON, AR & SLABAS, AR (1994). Studies on wheat acetyl CoA carboxylase and the cloning of a partial cDNA. Plant Molecular Biology 24(1): 21-34.
• MARTINEZRIVAS, JM, THOMAS, NC, CHASE, D, FAWCETT, T & SLABAS, AR (1993). cDNA Cloning and overexpression of 3-Oxoacyl-ACP Reductase from Brassica napus seed. Grasas Y Aceites 44(2): 119-122.
• FOULDS, IJ, LEA, VJ, SIDEBOTTOM, C, JAMES, CM, BOULTON, RE, BREARS, T, SLABAS, AR, JACK, PL & STRATFORD, R (1993). Cloning and sequence analysis of the coat protein gene of barley mild mosaic virus. Virus Research 27(1): 79-89.
• LOADER, NM, WOOLNER, EM, HELLYER, A, SLABAS, AR & SAFFORD, R (1993). Isolation and characterization of two Brassica napus embryo acyl-ACP thioesterase cDNA clones. Plant Molecular Biology 23(4): 769-778.
• SAFFORD, R, MORAN, MT, DESILVA, J, ROBINSON, SJ, MOSCOW, S, JARMAN, CD & SLABAS, AR (1993). Regulated expression of the rat medium chain hydrolase gene in transgenic rape seed. Transgenic Research 2(4): 191-198.
• SHELDON, PS, KEKWICK, RGO, SMITH, CG, SIDEBOTTOM, C & SLABAS, AR (1992). 3-Oxoacyl-[ACP] reductase from oilseed rape (Brassica napus). Biochimica Et Biophysica Acta 1120(2): 151-159.
• MILLAR, DJ, SLABAS, AR, SIDEBOTTOM, C, SMITH, CG, ALLEN, AK & BOLWELL, GP (1992). A major stress-inducibal MR-42000 wall glycoprotein of French bean (Phaseolus-vulgaris L). Planta 187(2): 176-184.
• MILLAR, DJ, ALLEN, AK, SMITH, CG, SIDEBOTTOM, C, SLABAS, AR & BOLWELL, GP (1992). Chitin-binding proteins in potato (Solanum tuberosum L.) tuber. Characterization, immunolocalization and effects of wounding. Biochemical Journal 283: 813-821.
• HELLYER, A, LEADLAY, PF & SLABAS, AR (1992). Induction, purification and characterisation of acyl-ACP thioesterase from developing seeds of oil seed rape (Brassica napus). Plant Molecular Biology 20(5): 763-780.
• SLABAS, AR, CHASE, D, NISHIDA, I, MURATA, N, SIDEBOTTOM, C, SAFFORD, R, SHELDON, PS, KEKWICK, RGO, HARDIE, DG & MACKINTOSH, RW (1992). Molecular cloning of higher-plant 3-oxoacyl-(acyl carrier protein) reductase. Sequence identities with the nodG-gene product of the nitrogen-fixing soil bacterium Rhizobium meliloti. Biochemical Journal 283: 321-326.
• SLABAS, AR & FAWCETT, T (1992). The biochemistry and molecular biology of plant lipid biosynthesis. Plant Molecular Biology 19(1): 169-191.
• SLABAS, AR, COTTINGHAM, I, AUSTIN, A, FAWCETT, T & SIDEBOTTOM, CM (1991). Amino acid sequence analysis of rape seed (Brassica napus) NADH-enoyl ACP reductase. Plant Molecular Biology 17(4): 911-914.
• SIDEBOTTOM, CM, CHARTON, E, DUNN, PPJ, MYCOCK, G, DAVIES, C, SUTTON, JL, MACRAE, AR & SLABAS, AR (1991). Geotrichum candidum produces several lipases with markedly different substrate specificities. European Journal Of Biochemistry 202(2): 485-491.
• COUTTS, RHA, RIGDEN, JE, SLABAS, AR, LOMONOSSOFF, GP & WISE, PJ (1991). The complete nucleotide sequence of tobacco necrosis virus strain D. Journal Of General Virology 72: 1521-1529.
• SHELDON, PS, KEKWICK, RGO, SIDEBOTTOM, C, SMITH, CG & SLABAS, AR (1990). 3-Oxoacyl-(acyl-carrier protein) reductase from avocado (Persea americana) fruit mesocarp. Biochemical Journal 271(3): 713-720.
• SLABAS, AR, WINDUST, J & SIDEBOTTOM, CM (1990). Does sequence similarity of human choline esterase, Torpedo acetylcholine esterase and Geotrichum candidum lipase reveal the active site serine residue?. Biochemical Journal 269(1): 279-280.
• SLABAS, AR, COTTINGHAM, IR, AUSTIN, A, HELLYER, A, SAFFORD, R & SMITH, CG (1990). Immunological detection of NADH-specific enoyl-ACP reductase from rape seed (Brassica napus)--induction, relationship of alpha and beta polypeptides, mRNA translation and interaction with ACP. Biochimica Et Biophysica Acta 1039(2): 181-188.
• DOMONEY, C, FIRMIN, JL, SIDEBOTTOM, C, EALING, PM, SLABAS, A & CASEY, R (1990). Lipoxygenase heterogeneity in Pisum-sativum. Planta 181(1): 35-43.
• MACKINTOSH, RW, HARDIE, DG & SLABAS, AR (1989). A new assay procedure to study the induction of Beta-ketoacyl-ACP Synthase I and Synthase-II, and the complete purification of Beta-ketoacyl-ACP Synthase I from developing seeds of Oilseed rape(Brassica-napus). Biochimica Et Biophysica Acta 1002(1): 114-124.
• MACKINTOSH, RW, HARDIE, DG & SLABAS, AR (1989). Beta-ketoacyl-acyl-carrier protein synthase from developing seeds of oil seed rape (Brassica napus). Biochemical Society Transactions 17(4): 686-687.
• SLABAS, AR, AITKEN, A, HOWELL, S, WELHAM, K & SIDEBOTTOM, CM (1989). Identification of the N-terminal blocking group of rat mammary-gland acyl fatty-acid synthetase-thioesterase-II. Biochemical Society Transactions 17(5): 886-887.
• COTTINGHAM, IR, AUSTIN, AJ & SLABAS, AR (1989). Inhibition and covalent modification of rape seed (Brassica napus) enoyl ACP reductase by phenylglyoxal. Biochimica Et Biophysica Acta 995(3): 273-278.
• SHELDON, PS, SAFFORD, R, SLABAS, AR & KEKWICK, RGO (1988). 2-Oxoacyl (Acyl carrier protein) Reductase - A component of plant fatty-acid synthase. Biochemical Society Transactions 16(3): 392-393.
• SLABAS, AR & SMITH, CG (1988). Immunogold localization of acyl carrier protein in plants and Escherichia coli - Evidence for membrane association in plants. Planta 175(2): 145-152.
• SAFFORD, R, WINDUST, JHC, LUCAS, C, DESILVA, J, JAMES, CM, HELLYER, A, SMITH, CG, SLABAS, AR & HUGHES, SG (1988). Plastid-localised seed acyl-carrier protein of Brassica napus is encoded by a distinct, nuclear multigene family. European Journal Of Biochemistry 174(2): 287-295.
• COTTINGHAM, IR, AUSTIN, A, SIDEBOTTOM, C & SLABAS, AR (1988). Purified Enoyl-(Acyl-carrier protein) Reductase from Rape seed (Brassica napus)contains 2 closely related polypeptides which differ by a 6-amiino-acid N-terminal extension. Biochimica Et Biophysica Acta 954(2): 201-207.
• SLABAS, AR, HARDING, J, HELLYER, A, ROBERTS, P & BAMBRIDGE, HE (1987). Induction, purification and characterization of acyl carrier protein from developing seeds of oil seed rape(Brassica napus). Biochimica Et Biophysica Acta 921(1): 50-59.
• SAFFORD, R, DESILVA, J, LUCAS, C, WINDUST, JHC, SHEDDEN, J, JAMES, CM, SIDEBOTTOM, CM, SLABAS, AR, TOMBS, MP & HUGHES, SG (1987). Molecular cloning and sequence analysis of complementary DNA encoding rat mammary gland medium-chain S-acyl fatty acid synthetase thio ester hydrolase. Biochemistry 26(5): 1358-1364.
• DUNN, PPJ, SLABAS, AR & MOORE, AL (1986). Characterization of cuckoo-pint (Arum maculatum) mitochondrial adenosine triphosphatases. Biochemical Journal 233(3): 839-844.
• SLABAS, AR, SIDEBOTTOM, CM, HELLYER, A, KESSELL, RMJ & TOMBS, MP (1986). Induction, purification and characterization of NADH-specific enoyl acyl carrier protein reductase from developing seeds of oil seed rape (Brassica napus). Biochimica Et Biophysica Acta 877(2): 271-280.
• SLABAS, AR, SIDEBOTTOM, C, KESSELL, R, HELLYER, A & TOMBS, MP (1986). Oilseed rape NADH enoyl acyl-carrier protein reductase. Biochemical Society Transactions 14(3): 581-582.
• HELLYER, A, BAMBRIDGE, HE & SLABAS, AR (1986). Plant acetyl-CoA carboxylase. Biochemical Society Transactions 14(3): 565-568.
• SLABAS, AR, HELLYER, A & BAMBRIDGE, HE (1986). The basic polypeptide subunit of Rape leaf acetyl-coA carboxylase is a 220-kDa protein. Biochemical Society Transactions 14(4): 716-716.
• DUNN, PPJ, SLABAS, AR & MOORE, AL (1985). Purification of F1-ATPase from cuckoo-pint (Arum maculatum) mitochondria. A comparison of subunit composition with that of rat liver F1-ATPase. Biochemical Journal 225(3): 821-824.
• SLABAS, AR & HELLYER, A (1985). Rapid purification of a high molecular-weight subunit polypeptide form of rape seed acetyl coA carboxylase. Plant Science 39(3): 177-182.
• DUNN, PPJ, SLABAS, AR, COTTINGHAM, IR & MOORE, AL (1984). Trifluoperazine inhibition of electron transport and adenosine triphosphatase in plant mitochondria. Archives Of Biochemistry And Biophysics 229(1): 287-294.
• SLABAS, AR, ORMESHER, J, ROBERTS, PA, SIDEBOTTOM, CM, TOMBS, MP, JEFFCOAT, R & JAMES, AT (1983). The interaction of mammalian medium-chain hydrolase with yeast fatty acid synthetase. European Journal Of Biochemistry 134(1): 27-32.
• SLABAS, AR, ROBERTS, PA, ORMESHER, J & HAMMOND, EW (1982). Cuphea procumbens - A model system for studying the mechanism of medium-chain fatty-acid biosynthesis in plants. Biochimica Et Biophysica Acta 711(3): 411-420.
• LLOYD, CW, SLABAS, AR, POWELL, AJ & PEACE, GW (1982). Novel features of the plant cytoskeleton. Cell Biology International Reports 6(2): 171-175.
• POWELL, AJ, PEACE, GW, SLABAS, AR & LLOYD, CW (1982). The detergent-resistant cytoskeleton of higher plant protoplasts contains nucleus-associated fibrillar bundles in addition to microtubules. Journal Of Cell Science 56(AUG): 319-335.
• STUBBS, JM & SLABAS, AR (1982). Ultra structural and biochemical characterization of the epidermal hairs of the seeds of cuphea procumbens. Planta 155(5): 392-399.
• POWELL, AJ, LLOYD, CW, SLABAS, AR & COVE, DJ (1980). Demonstration of the microtubular cytoskeleton of the moss, physcomitrella-patens, using antibodies against mammalian brain tubulin. Plant Science Letters 18(4): 401-404.
• SLABAS, AR, POWELL, AJ & LLOYD, CW (1980). Improved procedure for the isolation and purification of protoplasts from carrot suspension cultures. Planta 147(4): 283-286.
• LLOYD, CW, SLABAS, AR, POWELL, AJ & LOWE, SB (1980). Microtubules, protoplasts and plant-cell shape - immunofluorescent study. Planta 147(5): 500-506.
• SLABAS, AR, MACDONALD, G & LLOYD, CW (1980). Selective purification of plant proteins which co-polymerise with mammalian microtubules. Febs Letters 110(1): 77-79.
• LLOYD, CW, SLABAS, AR, POWELL, AJ & PEACE, GW (1980). The detergent resistant cytoskeleton of higher-plant cells. European Journal Of Cell Biology 22(1): 299-299.
• SLABAS, AR, MACDONALD, G & LLOYD, CW (1980). Thymidine Metabolism and the Measurement of the Rate of DNA Synthesis in Carrot Suspension Cultures: EVIDENCE FOR A DEGRADATION PATHWAY FOR THYMIDINE. Plant Physiology 65(6): 1194-1198.
• LLOYD, CW, SLABAS, AR, POWELL, AJ, MACDONALD, G & BADLEY, RA (1979). Cytoplasmic microtubules of higher-plant cells visualized with anti-tubulin antibodies. Nature 279(5710): 239-241.
• SLABAS, AR & EVANS, MCW (1977). EPR signals in chloroplasts responding to illumination sequence of 4 flashes. Nature 270(5633): 169-171.
• SLABAS, AR & WHATLEY, FR (1977). Metabolic regulation of malic enzyme activity from Paracoccus denitrificans by glyoxylate and acetylCoA. Biochemical And Biophysical Research Communications 74(3): 1116-1124.
• SLABAS, AR & WHATLEY, FR (1977). Metabolic regulation of pyruvate kinase isolated from autotrophically and heterotrophically grown Paracoccus denitrificans. Archives Of Microbiology 115(1): 67-71.
• SLABAS, AR & WHATLEY, FR (1977). Metabolic regulation of the glucose-6-phosphate dehydrogenase from Paracoccus denitrifcans grown on glucose/nitrate. Archives Of Microbiology 112(2): 225-227.
• EVANS, MCW, SIHRA, CK & SLABAS, AR (1977). The oxidation-reduction potential of the reaction-centre chlorophyll (P700) in Photosystem I. Evidence for multiple components in electron-paramagnetic-resonance signal 1 at low temperature. Biochemical Journal 162(1): 75-85.
• SLABAS, AR (1976). CORRECTION. Biochemical Journal 156(3): U481-U481.
• SLABAS, AR & WALKER, DA (1976). Enzymic reconstitution of photosynthetic carbon assimilation. Pentose phosphate-dependent O evolution by illuminated envelope-free chloroplasts from Spinacia oleracea. Archives Of Biochemistry And Biophysics 175(2): 590-597.
• SLABAS, AR & WALKER, DA (1976). Inhibition of spinach phosphoribulokinase by DL-glyceraldehyde. Biochemical Journal 153(3): 613-619.
• SLABAS, AR & WALKER, DA (1976). Localization of inhibition by adenosine diphosphate of phosphoglycerate-dependent oxygen evolution in a reconstituted chloroplast system. Biochemical Journal 154(1): 185-192.
• WALKER, DA, SLABAS, AR & FITZGERALD, MP (1976). Photosynthesis in a reconstituted chloroplast system from spinach. Some factors affecting CO2-dependent oxygen evolution with fructose-1,6-bisphosphate as substrate. Biochimica Et Biophysica Acta 440(1): 147-162.
• WALKER, DA & SLABAS, AR (1976). Stepwise generation of the natural oxidant in a reconstituted chloroplast system. Plant Physiology 57(2): 203-208.
• SLABAS, AR & WALKER, DA (1976). Transient inhibition by ribose 5-phosphate of photosynthetic O2 evolution in a reconstituted chloroplast system. Biochimica Et Biophysica Acta 430(1): 154-164.
• SLABAS, AR & WHATLEY, FR (1974). Regulation of pyruvate-kinase in micrococcus-denitrificans. Biochemical Society Transactions 2(5): 929-930.