All Staff

Prof A Walmsley

Professor in the School of Biological and Biomedical Sciences

Telephone: +44 (0) 191 33 49165

Member of the Durham X-ray Centre

Contact Prof A Walmsley

Research Groups

Biomolecular Interactions

Research Projects

Centre for Bioactive Chemistry

The MtrR transcription regulator as a novel target for antimicrobial chemotherapy

Research Interests

Antibiotic Resistance
Membrane transporters
Molecular genetic studies of the human pathogenic fungus Paracoccidioides brasiliensis.

Selected Publications

Journal papers: academic

Janganan, TK, Bavro, V, Zhang, L, Borges-Walmsley, MI & Walmsley, AR (2013). Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump. Molecular Microbiology 88(3): 590.
Janganan, TK, Bavro, VN, Zhang, L, Matak-Vinkovic, D, Barrera, NP, Venien-Bryan, C, Robinson, CV, Borges-Walmsley, MI & Walmsley, AR (2011). Evidence for the assembly of a bacterial tripartite multidrug pump with a stoichiometry of 3:6:3. The Journal of Biological Chemistry 286(30): 26900-26912.
Janganan, TK, Zhang, L, Bavro, VN, Matak-Vinkovic, D, Barrera, NP, Burton, MF, Steel, PG, Robinson, CV, Borges-Walmsley, MI & Walmsley, AR. (2011). Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner. Journal of Biological Chemistry 286(7): 5484-5493.
Lin, HT, Bavro, VN, Barrera, NP, Frankish, HM, Velamakanni, S, van Veen, HW, Robinson, CV, Borges-Walmsley, MI & Walmsley, AR (2009). MacB ABC transporter is a dimer whose ATPase activity and macrolide-binding capacity are regulated by the membrane fusion protein MacA. The Journal of Biological Chemistry 284(2): 1145-1154.
Barrera, NP, Isaacson,C, Zhou, M, Bavro, VN, Welch, A, Schaedler, TA, Seeger, MA, Miguel, RN, Korkhov, VM, van Veen, HW, Venter, H, Walmsley, AR, Tate, CG & Robinson, CV (2009). Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions. Nature Methods 6(8): 585-587
Lin, Yung-Feng., Walmsley, Adrian R. & Rosen, Barry P. (2006). An arsenic metallochaperone for an arsenic detoxification pump. Proceedings of the National Academy of Sciences of the United States of America 103(42): 15617-15622.
Walmsley, A, M.I. Borges-Walmsley, D. Du, K.S. McKeegan & G.J. Sharples (2005). VceR regulates the vceCAB drug efflux pump operon of Vibrio cholerae by alternating between mutually exclusive conformations that bind either drugs or promoter DNA. Journal of Molecular Biology 349: 387-400.
Walmsley, A, K.S. McKeegan & M.I. Borges-Walmsley (2004). Efflux pumps as mechanisms of resistance and ways to overcome it. Current opinion in pharmacology 4: 479-486.
Walmsley, A, Ruano, JM, Glidle, A, Cleary, A, Aitchison, JS & Cooperm JM (2003). Design and Fabrication of a Silica on Silicon Integrated Optical Biochip as a Fluorescence Microarray Platform. Biosensors and Bioelectronics 18: 175/184.
Borges-Walmsley, MI, Beauchamp, J, Kelly, SM, Jumel, K, Candlish, D, Harding, SE, Price, NC & Walmsley, A (2003). Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA. Journal of Biological Chemistry 278(15): 12903-12912.
Walmsley, A, Gray, CH, Borges-Walmsley, MI & Evans, GJ (2003). The pfr1 gene from the human pathogenic fungus Paracoccidioides brasiliensis encodes a half-ABC transporter that is transcribed in response to treatment with fluconazole. Yeast 20(10): 865-880.
Walmsley, A, McKeegan, KS & Borges-Walmsley, MI (2003). The structure and function of drug pumps; an update. Trends in Microbiology 11(1): 21-29.
Song, L, Rosen, BP, Borges-Walmsley, MI & Walmsley, A (2002). Evidence for Cooperativity between the Four Binding Sites of Dimeric ArsD, an As (III)-responsive Transcriptional Regulator. Journal of Biological Chemistry 277(29): 25992-26002.
Walmsley, A, Borges-Walmsley, MI & McKeegan, KS (2002). Microbial and viral drug resistance mechanisms. A Trends Guide to Infectious Diseases. Trends in Microbiology 10(10 Suppl): S8-14.
Walmsley, A, Baillie, G, Huston, E, Scotland, G, Warwicker, J, Hodgkin, MN, Gall, I, Currie, R, Wakelam, MJO & Houslay, MD (2002). TAPAS-1, a novel microdomain that allows rapid, Ca2+-dependent membrane association with selectivity for interaction with phosphatidic acid. Journal of Biological Chemistry 277(29): 28298-28309.
A Walmsley, T. Zhou, M.I. Borges-Walmsley & B.P. Rosen (2001). A kinetic model for the action of a resistance efflux pump. Journal of Biological Chemistry 276(9): 6378-6391.
A.R. Walmsley, , T. Zhou, M.I. Borges-Walmsley & B.P. Rosen (2001). Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump. Biochemical Journal 360: 589-597.
A.R. Walmsley, T. Zhou, M.I. Borges-Walmsley & B.P. Rosen (1999). Transient kinetic studies of the ArsA ATPase, the catalytic subunit of the arsenical transporter. The Journal of Biological Chemistry 274: 16153-16161.

Show all publications