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School of Biological and Biomedical Sciences

Academic Staff

Publication details for Dr Paul Denny

Denny, PW, Morgan, GW, Field, MC & Smith, DF (2005). Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite. Experimental Parasitology 109(1): 33-37.
  • Publication type: Journal papers: academic
  • ISSN/ISBN: 0014-4894
  • DOI: 10.1016/j.exppara.2004.10.007
  • Keywords: Leishmania; kinetoplastid; intra-macrophage parasite; clathrin;adaptin; evolution; traffickingPROTEIN COMPLEX; PARASITOPHOROUS VACUOLES; MEDIATED ENDOCYTOSIS;TRYPANOSOMA-BRUCEI; MACROPHAGES; AMAZONENSIS; PROTOZOAN; MOLECULES;MEXICANA; SYSTEM
  • View online: Online version
  • Durham research online: DRO record

Author(s) from Durham

Abstract

To investigate the role of clathrin-mediated trafficking during the Leishmania lifecycle, open reading frames encoding clathrin heavy chain and the β-adaptins, major components of the adaptor complexes, have been analysed both in silico and experimentally. The Leishmania genome encodes three β-adaptins, which arose at a time predating speciation of these divergent trypanosomatids. Unlike Trypanosoma brucei, both clathrin heavy chain and β-adaptin1 are constitutively expressed throughout the Leishmania life cycle. Clathrin relocalises in amastigotes relative to promastigotes, consistent with developmental alterations to the morphology of the endo-membrane system.