Academic Staff

Dr I Karakesisoglou

(email at iakowos.karakesisoglou@durham.ac.uk)

Biography

Bsc: 1993 University of Athens, Greece
PhD: 1996 Ludwig-Maximilians University Munich, Germany
Postdoctoral fellow: 1997-2002 University of Chicago, USA
Group leader: 2002-2007 University of Cologne, Germany
Senior Lecturer: 2007-present University of Durham, UK

Research Interests

Cytoskeleton Linker Proteins (Nesprins and Spectraplakins)
Nuclear Envelope Structure and Function
Premature and Physiological Ageing
Laminopathies
Tissue and Animal Morphogenesis

Research Groups

• Cell Structure
• Development and Regeneration
• Durham Centre for Bioimaging Technology

Publications

Journal papers: academic

• Taranum, S., Sur, I., Muller, R., Lu, W. Rashmi, R.N. Munch, M., Neumann, S., Karakesisoglou, I. & Noegel, A.A. (2012). Cytoskeletal interactions at the nuclear envelope mediated by Nesprins. International Journal of Cell Biology 2012: 736524.
• Taranum, S., Vaylann, E., Meinke, P., Abraham, S., Yang, L., Neumann, S., Karakesisoglou, I., Wehnert, M. & Noegel, A.A. (2012). LINC complex alterations in DMD and EDMD/CMT fibroblasts. European Journal of Cell Biology 91(8): 614-628.
• Lu, W,, Schneider,M,, Neumann, S,, Jaeger, V-M, Taranum, S,, Munck, M,, Cartwright, S,, Richardson, C,, Carthew, J,, Noh, K,, Goldberg, M,, Noegel, A, & Karakesisoglou, I. (2012). Nesprin interchain associations control nuclear size. Cellular and Molecular Life Sciences 69(20): 3493-3509.
• Rashmi R.N., Eckes B., Glöckner G., Groth M., Muller R., Munck M., Neumann S., Gloy J., Sellin L., Walz G., Schneider M., Karakesisoglou I., Eichinger L. & Noegel A.A. (2012). Roles for nuclear envelope associated Nesprin-2 Giant in cell differentiation, proliferation and chromatin association in a mouse model. Nucleus 3(2): 172-186.
• Schneider, M., Lu, W., Neumann, S., Brachner, A., Gotzmann, J., Noegel, A.A. & Karakesisoglou, I. (2011). Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cellular and Molecular Life Sciences 68(9): 1593-1610.
• Zwerger, M., Kolb, T., Richter, K., Karakesisoglou, I. & Herrmann, H. (2010). Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7. Molecular Biology of the Cell 21(2): 354-368.
• Neumann, S., Schneider, M., Daugherty, R.L., Gottardi, C.J., Eming, S., Beijer, A., Noegel, A.A. & Karakesisoglou, I. (2010). Nesprin-2 interacts with α-Catenin and regulates Wnt signaling at the nuclear envelope. Journal of Biological Chemistry 285(45): 34932-34938.
• A.L. Olins, T.V. Hoang, M. Zwerger, H. Herrmann, H. Zentgraf, A.A. Noegel, I. Karakesisoglou, D. Hodzic & D.E. Olins (2009). The LINC-less granulocyte nucleus. Eur J Cell Biol 88(4): 203-14.
• W. Stoffel, B. Holz, B. Jenke, E. Binczek, R.H. Gunter, C. Kiss, I. Karakesisoglou, M. Thevis, A.A. Weber, S. Arnhold & K. Addicks (2008). Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. EMBO Journal 27(17): 2281-2292.
• M. Schneider, A.A. Noegel & I. Karakesisoglou (2008). KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope. Biochem Soc Trans 36(Pt 6): 1368-72.
• Y. Luke, H. Zaim, I. Karakesisoglou, V.M. Jaeger, L. Sellin, W. Lu, M. Schneider, S. Neumann, A. Beijer, M. Munck, V.C. Padmakumar, J. Gloy, G. Walz & A.A. Noegel (2008). Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. Journal of Cell Science 121(11): 1887-1898.
• W. Lu, J. Gotzmann, L. Sironi, V.M. Jaeger, M. Schneider, Y. Luke, M. Uhlen, C.A. Szigyarto, A. Brachner, J. Ellenberg, R. Foisner, A.A. Noegel & I. Karakesisoglou (2008). Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta 1783(12): 2415-26.
• V. Peche, S. Shekar, M. Leichter, H. Korte, R. Schroder, M. Schleicher, T.A. Holak, C.S. Clemen, Y.B. Ramanath, G. Pfitzer, I. Karakesisoglou & A.A. Noegel (2007). CAP2, cyclase-associated protein 2, is a dual compartment protein. Cell Mol Life Sci 64(19-20): 2702-15.
• S. Kandert, Y. Luke, T. Kleinhenz, S. Neumann, W. Lu, V.M. Jaeger, M. Munck, M. Wehnert, C.R. Muller, Z. Zhou, A.A. Noegel, M.C. Dabauvalle & I. Karakesisoglou (2007). Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. Human Molecular Genetics 16(23): 2944-2959.
• Libotte, T., Zaim, H., Abraham, S., Padmakumar, V. C., Schneider, M., Lu, W. S., Munck, M., Hutchison, C., Wehnert, M., Fahrenkrog, B., Sauder, U., Aebi, U., Noegel, A. A. & Karakesisoglou, I. (2005). Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Molecular Biology of the Cell 16(7): 3411-3424.
• Padmakumar, V. C., Libotte, T., Lu, W. S., Zaim, H., Abraham, S., Noegel, A. A., Gotzmann, J., Foisner, R. & Karakesisoglou, I. (2005). The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Journal of Cell Science 118(15): 3419-3430.
• V.C. Padmakumar, S. Abraham, S. Braune, A.A. Noegel, B. Tunggal, I. Karakesisoglou & E. Korenbaum (2004). Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 295(2): 330-9.
• Kodama, A., Karakesisoglou, I., Wong, E., Vaezi, A. & Fuchs, E. (2003). ACF7: An essential integrator of microtubule dynamics. Cell 115(3): 343-354.
• Fuchs, E. & Karakesisoglou, I. (2001). Bridging cytoskeletal intersections. Genes & Development 15(1): 1-14.
• Karakesisoglou, I., Yang, Y. M. & Fuchs, E. (2000). An epidermal plakin that integrates actin and microtubule networks at cellular junctions. Journal Of Cell Biology 149(1): 195-208.
• Lee, S. S., Karakesisoglou, I., Noegel, A. A., Rieger, D. & Schleicher, M. (2000). Dissection of functional domains by expression of point-mutated profilins in Dictyostelium mutants. European Journal Of Cell Biology 79(2): 92-103.
• Karakesisoglou, I., Janssen, K. P., Eichinger, L., Noegel, A. A. & Schleicher, M. (1999). Identification of a suppressor of the Dictyostelium profilin-minus phenotype as a CD36/LIMP-II homologue. Journal Of Cell Biology 145(1): 167-181.
• U. Gottwald, R. Brokamp, I. Karakesisoglou, M. Schleicher & A.A. Noegel (1996). Identification of a cyclase-associated protein (CAP) homologue in Dictyostelium discoideum and characterization of its interaction with actin. Mol Biol Cell 7(2): 261-72.
• Karakesisoglou, I., Schleicher, M., Gibbon, B. C. & Staiger, C. J. (1996). Plant profilins rescue the aberrant phenotype of profilin-deficient Dictyostelium cells. Cell Motility And The Cytoskeleton 34(1): 36-47.
• M. Schleicher, B. Andre, C. Andreoli, L. Eichinger, M. Haugwitz, A. Hofmann, J. Karakesisoglou, M. Stockelhuber & A.A. Noegel (1995). Structure/function studies on cytoskeletal proteins in Dictyostelium amoebae as a paradigm. FEBS Lett 369(1): 38-42.
• M. Haugwitz, A.A. Noegel, J. Karakesisoglou & M. Schleicher (1994). Dictyostelium amoebae that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis, and development. Cell 79(2): 303-14.