Academic Staff
Dr N Hole
Senior Lecturer in the School of Biological and Biomedical Sciences
Telephone: +44 (0) 191 33 41244
Member of the Centre for Stem Cell Biology and Regenerative Medicine
Contact Dr N Hole (email at nicholas.hole@durham.ac.uk)
Research Groups
Research Interests
- Biological microenvironments
- Haematopoiesis
- Stem cells
- Telomerase biology
Publications
Journal papers: academic
- Bell, E., Richardson, G.D., Jahoda, C., Phillips, H.M., Henderson, D., Owens, W.A. & Hole, N. (2012). Dermal stem cells can differentiate down an endothelial lineage. Stem Cells and Development 21(16): 3019-3030.
- Richardson, G.D., Breault, D., Horrocks, G., Cormack, S., Hole, N. & Owens, W.A. (2012). Telomerase expression in the mammalian heart. The FASEB Journal 26(12): 4832-4840.
- Breault DT, Min IM, Carlone, DL, Farilla, LG, Ambruzs, DM, Henderson, DE, Algra, S, Montgomery, RK, Wagers, AJ & Hole, N (2008). Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proceedings of the National Academy of Sciences of the United States of America 105(30): 10420-10425.
- Stewart R, Yang C, Anyfantis G, Przyborski S, Hole N, Strachan T, Stojkovic M, Keith WN, Armstrong L & Lako M (2008). Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells. Regenerative Medicine 3(4): 505-522.
- Armstrong, L, Saretzki, G, Peters, H, Wappler, I, Evans, J, Hole, N, von Zglinicki, T & Lako, M (2005). Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage. Stem Cells 23(4): 516-529.
- Richardson GD, Arnott EC, Whitehouse CJ, Lawrence CM, Reynolds AJ, Hole N & Jahoda CA. (2005). Plasticity of rodent and human hair follicle dermal cells: implications for cell therapy and tissue engineering. Journal of Investigative Dermatology symposium proceedings 10(3): 180-183.
- Armstrong L, Lako M, van Herpe I, Evans J, Saretzki G & Hole N. (2004). A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Mechanisms of Development 121(12): 1509-1522.
- Armstrong L, Stojkovic M, Dimmick I, Ahmad S, Stojkovic P, Hole N & Lako M (2004). Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 22(7): 1142-1151.
- Jahoda CA, Whitehouse J, Reynolds AJ & Hole N (2003). Hair follicle dermal cells differentiate into adipogenic and osteogenic lineages. Experimental Dermatology 12(6): 849-859.
- Lako, M, Lindsay S, Lincoln J, Cairns PM, Armstrong L & Hole N (2001). Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro: role of Wnt3 in enhancing hematopoietic differentiation. Mechanisms of Development 103(1-2): 49-59.